Journal
MATERIALS LETTERS
Volume 328, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2022.133137
Keywords
Biomaterials; Crystal structure; Calcium phosphate; Ion doping; Silicon
Funding
- Science and Technology Program of Guangzhou [202102021127]
- Fundamental Research Funds for the Central Universities [21622408]
- National Innovation and Entrepreneurship Training Program for Undergraduate [202110559103]
- Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation (Climbing Program Special Funds) [pdjh2022b0061]
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Silicon-doped octacalcium phosphate (OCP) with lattice contraction successfully enhances the proliferation and osteogenic capacities of bone marrow mesenchymal stem cells through the synergistic effect of bioactive ions release and mineral deposits, providing a potential bone substitute.
Silicon was successfully doped into an intermediate precursor of biological apatite, octacalcium phosphate (OCP), accompanied with a lattice contraction. Si-doped OCP significantly enhanced the proliferation and osteogenic capacities of bone marrow mesenchymal stem cells by the synergistical effect of bioactive ions release and mineral deposits, providing a potential bone substitute.
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