Vascular graft with native-like mechanical properties

Elastomeric SG-80A and SG-93A polyurethanes (PUs) were electrospun separately to develop microfibrous vascular grafts. The mechanical properties, suture retention strength, and burst pressure of the grafts were compared to coronary arteries (CA). Biodegradation of the graft materials and adhesion of porcine blood outgrowth endothelial cells (PBOECs) to the graft surfaces were evaluated in vitro. The SG-80A grafts showed tensile properties, suture retention strength, and burst pressure lower than SG-93A grafts but similar to CA. No graft materials were degraded in the enzymatic or oxidative environment over 30 days. Both grafts supported PBOEC adhesion.

Automated summary

Elastomeric SG-80A and SG-93A polyurethanes were electrospun into microfibrous vascular grafts, which were compared with coronary arteries in terms of mechanical properties, suture retention strength, and burst pressure. In vitro evaluation showed no degradation of the graft materials in enzymatic or oxidative environment over 30 days, and both grafts supported the adhesion of PBOECs.