Journal
MATERIALS & DESIGN
Volume 226, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2023.111670
Keywords
Wound dressing; Antibacterial activity; Hot spring effect; Angiogenesis; Infected wound healing
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This study constructed a nanofiber material with antibacterial and pro-angiogenic effects, which can accelerate wound healing and reduce the occurrence of infection by adding nanosilvers and black phosphorus.
Infected wound healing remains a significant issue in clinical medicine and has attracted wide attention in the field of biomedical engineering. Although a range of bioactive materials have been developed, few provide sufficient antibacterial and pro-angiogenic effects for effective wound healing. Herein, we con-structed a series of nanofibers (termed PL-n, n = 0,1, and 2) based on polycaprolactone (PCL), nanosilvers (AgNPs) and black phosphorus (BP) using electrospinning technology. The water contact angle of PL-n decreased significantly from 144.00 +/- 1.00 degrees for PL-0 to 0 degrees for PL-2. The photothermal temperature increased significantly from 27.27 +/- 0.25 degrees C for PL-0 to 40.7 +/- 0.15 degrees C for PL-2. After exposure to near -infrared ray (NIR), the release rate of PL-2 increased from 78.00 +/- 2.95 % to 89.46 +/- 2.05 %. Biological experiments demonstrated that NIR-assisted PL-2 has excellent antibacterial and biofilm ablation activity with good biocompatibility. Furthermore, in vivo studies indicated that the NIR-assisted PL-2 accelerated wound healing by stimulating granulation tissue formation, collagen deposition, and angiogenesis and decreasing expression levels of CD68. The study suggests that this bi-functional nanofiber is indeed a ver-satile wound dressing, and is expected to be applied in clinical settings. (c) 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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