Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 131, Issue 1, Pages 64-67Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1016/j.jphs.2016.01.002
Keywords
Pregabalin; Fibromyalgia; P-glycoprotein
Categories
Funding
- Platform for Drug Discovery, Informatics, and Structural Life Science - Japan Agency for Medical Research and Development
- JSPS KAKENHI [26253077]
- Grants-in-Aid for Scientific Research [26253077] Funding Source: KAKEN
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Pregabalin (PGB) is a valuable therapeutic drug against chronic pain. Here we attempted to perform the combinatorial drug therapy with P-glycoprotein (P-gp) inhibitors to lower therapeutic dosage of PGB in the intermittent cold stress-induced fibromyalgia-like pain model. Single intracerebroventricular (i.c.v.) PGB injection exerted long-lasting anti-hyperalgesic effects for 72 h, while the effect of PGB given intraperitoneally (i.p.) disappeared within 3 h. Importantly, the pretreatment with P-gp inhibitors markedly prolonged the PGB (i.p.) effects, which lasted for 72 h. These results suggest that the combinatorial treatment with P-gp inhibitor enables the prolongation of dose-interval for PGB. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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