4.7 Article

Gold Nanoparticles Synthesized by an Aqueous Extract of Codium tomentosum as Potential Antitumoral Enhancers of Gemcitabine

Related references

Note: Only part of the references are listed.
Article Oncology

Sequence Therapy with FOLFIRINOX and Gemcitabine/Nab-Paclitaxel for Patients with Advanced Pancreatic Cancer: A Monocentre Retrospective Cohort Study

Alexander Queck et al.

Summary: This study investigated the treatment of 225 patients with pancreatic cancer and found that FOLFIRINOX treatment can temporarily control the tumor in the first-line, while combination therapy with gemcitabine and nab-paclitaxel in the second-line also achieved temporary tumor control. Patients who received second-line treatment had a better prognosis. More research is needed to demonstrate the superiority of combination therapy over monotherapy.

ONCOLOGY RESEARCH AND TREATMENT (2022)

Article Biochemistry & Molecular Biology

Thermochemical Characterization of Eight Seaweed Species and Evaluation of Their Potential Use as an Alternative for Biofuel Production and Source of Bioactive Compounds

Lucia Cassani et al.

Summary: This study evaluated the nutritional characteristics, thermochemical properties, and bioactivities of eight edible seaweeds. The results suggest that seaweeds have a rich nutritional profile, potential as an alternative biofuel source, and provide functional benefits.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Chemistry, Medicinal

Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts

Noelia Gonzalez-Ballesteros et al.

Summary: This study reports on the green and cost-efficient synthesis of gold nanoparticles from three different red algae extracts. The obtained nanoparticles were characterized and confirmed to have significant potential as immunotherapeutic agents.

MARINE DRUGS (2022)

Article Environmental Sciences

Controlling Light to Optimize Growth and Added Value of the Green Macroalga Codium tomentosum

Ruben Marques et al.

Summary: This study investigates the seasonal effects of light intensity and wavelength on productivity, pigment composition, and epiphyte overgrowth in Codium tomentosum cultured in a land-based integrated multi-trophic aquaculture system. The study demonstrates that optimizing light conditions is crucial for algal growth and the production of high-value compounds. Additionally, controlling light can reduce epiphyte overgrowth and enhance the valorization of macroalgal biomass.

FRONTIERS IN MARINE SCIENCE (2022)

Review Nanoscience & Nanotechnology

Systematic and mechanistic analysis of AuNP-induced nanotoxicity for risk assessment of nanomedicine

Euiyeon Lee et al.

Summary: Gold nanoparticles (AuNPs) have unique properties that make them widely used in various biomedical applications. However, there is still a lack of understanding about the biological and pathological effects of AuNPs. The biological fate of AuNPs is related to their physicochemical parameters, and evaluating these parameters' effects on biological interactions is a challenge. This review focuses on ongoing nanotoxicology studies that aim to characterize the effect of various AuNP characteristics on AuNP-induced toxicity.

NANO CONVERGENCE (2022)

Article Chemistry, Medicinal

Synergistic Antitumoral Effect of Epigenetic Inhibitors and Gemcitabine in Pancreatic Cancer Cells

Immacolata Maietta et al.

Summary: Epigenetic modifications play a crucial role in the proliferation, drug resistance, and metastasis of pancreatic ductal adenocarcinoma (PDAC). In this study, researchers tested the effects of different epigenetic enzyme inhibitors and a drug that restores p53 function on PDAC cell lines. The results showed that inhibiting certain enzymes or combining drugs with gemcitabine can significantly reduce cell viability and potentially serve as a new treatment strategy for PDAC. RNA-Seq analysis also identified potential biomarkers for synergy.

PHARMACEUTICALS (2022)

Article Chemistry, Physical

Flower, stem, and leaf extracts from Hypericum perforatum L. to synthesize gold nanoparticles: Effectiveness and antioxidant activity

R. Rey-Mendez et al.

Summary: This study synthesized gold nanoparticles using different parts of Hypericum perforatum and characterized them using various methods. The nanoparticles showed enhanced antioxidant activity compared to the plant extracts.

SURFACES AND INTERFACES (2022)

Article Oncology

Antitumor immunity and therapeutic properties of marine seaweeds-derived extracts in the treatment of cancer

Mostafa M. El-Sheekh et al.

Summary: This study evaluated the antitumor and antitumor immunological potentials of extracts from brown alga Padinapavonica and red alga Janiarubens. The extracts showed effective inhibition of liver cancer cells in vitro and enhanced antitumor immunity in vivo. They also reduced tumor cell viability and increased lymphocyte count while decreasing neutrophils and monocytes. These extracts have potential antitumor and immunological effects with low toxicity, suggesting further investigation into their mechanisms.

CANCER CELL INTERNATIONAL (2022)

Review Chemistry, Inorganic & Nuclear

Green synthesis of silver and gold nanoparticles and their potential applications as therapeutics in cancer therapy; a review

Rania H. Taha

Summary: Cancer, which is one of the leading causes of death globally, can be treated with nanotechnology using bio-mediated nanoparticles. The use of silver and gold nanoparticles has shown promising results in cancer therapy due to their low risk profile and fewer side effects. The production of reactive oxygen species in cellular compartments is believed to be responsible for the anticancer properties of these nanoparticles.

INORGANIC CHEMISTRY COMMUNICATIONS (2022)

Review Biochemistry & Molecular Biology

Advances in anti-cancer effects and underlying mechanisms of marine algae polysaccharides

Wanzi Yao et al.

Summary: Cancer is a major health problem worldwide, and marine algae polysaccharides (MAPs) have gained attention for their excellent anti-cancer abilities. This review aims to update the discovery and evaluation of MAPs with anti-cancer properties and elucidate their mechanisms of action.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

Article Biochemistry & Molecular Biology

Neuroprotective Effect of Gold Nanoparticles and Alpha-Lipoic Acid Mixture against Radiation-Induced Brain Damage in Rats

Noha F. Abdelkader et al.

Summary: This study investigates the neuroprotective effects of gold nanoparticles and alpha-lipoic acid mixture on brain damage caused by radiation in rats. The results show that the mixture can alleviate oxidative stress, DNA damage, and histopathological changes in brain tissues.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Medicine, General & Internal

Anti-colorectal cancer effects of seaweed-derived bioactive compounds

Yunhua Fu et al.

Summary: Seaweeds, classified into different categories, contain bioactive compounds with anticancer properties. This review focuses on the potential utility of seaweeds as anticancer agents, particularly in the context of colorectal cancer. The mechanisms through which seaweed-derived compounds induce apoptosis in colorectal cancer cells are explored.

FRONTIERS IN MEDICINE (2022)

Article Biotechnology & Applied Microbiology

Effects of photoperiod and light spectra on growth and pigment composition of the green macroalga Codium tomentosum

Ruben Marques et al.

Summary: This study investigated the effects of photoperiod and light spectra on the growth and pigment composition of C. tomentosum, revealing that long-day photoperiod and red light were optimal for growth at early development stages.

JOURNAL OF APPLIED PHYCOLOGY (2021)

Article Chemistry, Physical

Cytotoxicity behaviour of response surface model optimized gold nanoparticles by utilizing fucoidan extracted from padina tetrastromatica

S. Rajeshkumar et al.

Summary: The study utilized sulphated polysaccharide extracted from marine brown seaweed to synthesize gold nanoparticles, and confirmed their structure and anti-cancer activity through various experimental techniques.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Biochemistry & Molecular Biology

Loliolide, a New Therapeutic Option for Neurological Diseases? In Vitro Neuroprotective and Anti-Inflammatory Activities of a Monoterpenoid Lactone Isolated from Codium tomentosum

Joana Silva et al.

Summary: The study found that Loliolide extracted from seaweed can effectively prevent neuronal cell death and has anti-inflammatory effects, providing insights for the development of new neuroprotective therapeutic agents, warranting further detailed studies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Chemistry, Multidisciplinary

Nanomedicines accessible in the market for clinical interventions

Vedant Gadekar et al.

Summary: Nanomedicines, also known as nano-pharmaceuticals, have shown great potential in improving therapeutic efficacy and reducing side effects. Despite a considerable market share, challenges such as safety, regulatory hurdles, and cost need to be addressed for their market entry. This review discusses the current market status, challenges, and potential of nanomedicines.

JOURNAL OF CONTROLLED RELEASE (2021)

Review Biochemistry & Molecular Biology

Pancreatic Cancer and Therapy: Role and Regulation of Cancer Stem Cells

Susmita Barman et al.

Summary: Despite advancements in clinical management, pancreatic cancer remains deadly due to late detection and high metastatic properties. Pancreatic cancer stem cells have been found to play a crucial role in tumorigenesis, progression, and chemoresistance, but targeting them effectively remains a challenge due to cancer heterogeneity and complex signaling pathways regulating PC progression.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Eco-friendly extraction of Mastocarpus stellatus carrageenan for the synthesis of gold nanoparticles with improved biological activity

N. Gonzalez-Ballesteros et al.

Summary: The study investigated the extraction of carrageenan from Mastocarpus stellatus and its application in the green synthesis of gold nanoparticles. The synthesized gold nanoparticles exhibited good stability, negative charge, and higher antioxidant activity in cells.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Review Oncology

Hepatic Arterial Infusion of Chemotherapy for Advanced Hepatobiliary Cancers: State of the Art

Carmelo Laface et al.

Summary: Liver functional failure contributes significantly to cancer-related mortality. Systemic chemotherapy offers modest benefits for disease control and survival, but with notable adverse effects. Liver malignancies are mostly perfused by the hepatic artery, leading to the strategy of hepatic arterial infusion of chemotherapy. Current studies show favorable safety and efficacy outcomes for this approach in advanced hepatobiliary cancers, warranting further large-scale studies for confirmation.

CANCERS (2021)

Review Biotechnology & Applied Microbiology

Fucoidans: The importance of processing on their anti-tumoral properties

M. D. Torres et al.

ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS (2020)

Review Chemistry, Medicinal

Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential

Imen Saadaoui et al.

MARINE DRUGS (2020)

Article Cell Biology

Seaweeds' neuroprotective potential set in vitro on a human cellular stress model

Joana Silva et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity

Gabriel Tao et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2020)

Article Multidisciplinary Sciences

A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

Ravi S. Narayan et al.

NATURE COMMUNICATIONS (2020)

Review Nanoscience & Nanotechnology

A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy

Weiwei Mu et al.

NANO-MICRO LETTERS (2020)

Review Chemistry, Multidisciplinary

Advances in Gold Nanoparticle-Based Combined Cancer Therapy

Kyle Bromma et al.

NANOMATERIALS (2020)

Article Biochemistry & Molecular Biology

Natural Approaches for Neurological Disorders-The Neuroprotective Potential of Codium tomentosum

Joana Silva et al.

MOLECULES (2020)

Article Chemistry, Multidisciplinary

Synthesis of silver and gold nanoparticles by Sargassum muticum biomolecules and evaluation of their antioxidant activity and antibacterial properties

N. Gonzalez-Ballesteros et al.

JOURNAL OF NANOSTRUCTURE IN CHEMISTRY (2020)

Article Materials Science, Biomaterials

Macroalgae to nanoparticles: Study of Ulva lactuca L. role in biosynthesis of gold and silver nanoparticles and of their cytotoxicity on colon cancer cell lines

Noelia Gonzalez-Ballesteros et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Article Environmental Sciences

Cytotoxic activity of the seaweed compound fucosterol, alone and in combination with 5-fluorouracil, in colon cells using 2D and 3D culturing

Alice A. Ramos et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2019)

Review Biochemical Research Methods

Gold nanoparticles in chemo-, immuno-, and combined therapy: review [Invited]

L. A. Dykman et al.

BIOMEDICAL OPTICS EXPRESS (2019)

Article Materials Science, Biomaterials

Immunostimulant and biocompatible gold and silver nanoparticles synthesized using the Ulva intestinalis L. aqueous extract

N. Gonzalez-Ballesteros et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

Review Pharmacology & Pharmacy

Anticancer activity of seaweeds

Anliely G. Gutierrez-Rodriguez et al.

DRUG DISCOVERY TODAY (2018)

Article Biochemistry & Molecular Biology

Physico-chemical characterization and beneficial effects of seaweed sulfated polysaccharide against oxydatif and cellular damages caused by alloxan in diabetic rats

Rihab Ben Abdallah Kolsi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Review Biochemistry & Molecular Biology

Magnetic nanoparticles: A multifunctional vehicle for modern theranostics

M. Angelakeris

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

Article Biophysics

Green synthesis of gold nanoparticles using brown algae Cystoseira baccata: Its activity in colon cancer cells

N. Gonzalez-Ballesteros et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

Review Chemistry, Analytical

Bioconjugated Nanoparticles for Biosensing, in Vivo Imaging, and Medical Diagnostics

Brad A. Kairdolf et al.

ANALYTICAL CHEMISTRY (2017)

Article Emergency Medicine

An Approach to Chemotherapy-Associated Toxicity

Zhanna Livshits et al.

EMERGENCY MEDICINE CLINICS OF NORTH AMERICA (2014)

Article Chemistry, Applied

Green synthesis of silver nanoparticles using polysaccharides extracted from marine macro algae

H. M. El-Rafie et al.

CARBOHYDRATE POLYMERS (2013)

Article Chemistry, Applied

Phenolic compounds and antioxidant activities of selected species of seaweeds from Danish coast

K. H. Sabeena Farvin et al.

FOOD CHEMISTRY (2013)

Article Multidisciplinary Sciences

Antioxidant activity of the stem bark of Shorea roxburghii and its silver reducing power

Ramasamy Subramanian et al.

SPRINGERPLUS (2013)

Article Nanoscience & Nanotechnology

Green synthesis of silver nanoparticles using marine macroalga Chaetomorpha linum

R. Ragupathi Raja Kannan et al.

APPLIED NANOSCIENCE (2013)