Journal
MARINE DRUGS
Volume 20, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/md20110716
Keywords
elderly; inflammageing; Phaeodactylum tricornutum; omega-3-fatty acids; eicosapentaenoic acid; fucoxanthin; beta-glucan; chrysolaminarin
Categories
Funding
- Gesellschaft fuer Angewandte Vitaminforschung (GVF)
- Society of Nutrition and Food Science (SNFS)
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Dietary supplements that promote healthy aging are necessary in an aging society. A randomized controlled trial showed that microalgae rich in eicosapentaenoic acid, carotenoids, vitamins, and beta-glucans have anti-inflammatory and potentially anti-oxidative effects, which may have positive effects on healthy elderly individuals.
Dietary supplements that promote healthy aging are mostly warranted in an aging society. Because of age-related risks, anti-inflammatory and anti-oxidative agents such as microalgae are potential candidates for intervention. In a randomized controlled trial, we tested Phaeodactylum tricornutum (PT), a microalgae rich in eicosapentaenoic acid (EPA), carotenoids, vitamins, and beta-glucans, cultured in bioreactors. In this pilot trial, 19 healthy elderly received supplements for two weeks based on either the whole PT (A), the beta-1,3-glucan-rich PT supernatant (SupB), the combination thereof (A+SupB), or a Comparator product (Comp). The primary outcome variable plasma interleukin-6 was reduced after treatment with A+SupB compared to the Comp group (p = 0.04). The mobility parameters 5 s sit-to-stand test (p = 0.04 in the A group) and by trend gait speed (p = 0.08 in the A+SupB diet) were improved compared to Comp. No treatment effects were observed for fatty acids, compared to Comp but omega-6 to -3 fatty acid ratio (p = 0.006) and arachidonic acid/EPA ratio (p = 0.006) were reduced within group A+SupB. Further, the SupB study product reduced faecal zonulin (p = 0.03) compared to the Comp. The data revealed an anti-inflammatory and potentially anti-oxidative effect of particular PT preparations, suggesting that they might be suitable for effects in healthy elderly.
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