Journal
MARINE DRUGS
Volume 20, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/md20120765
Keywords
sulfur-containing natural products; fungi; chemical structures; bioactivities
Categories
Funding
- National Natural Science Foundation of China [41906106]
- Natural Science Foundation of Guangdong Province, China [2021A1515011416]
- Guangdong Provincial Special Fund for Marine Economic Development Project [GDNRC (2021)054]
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This review summarizes the chemical structures and biological activities of 89 new fungal-derived sulfur-containing metabolites discovered from marine and terrestrial fungi. The review also briefly discusses the preliminary mechanism for C-S bond formation in fungi.
Organosulfur natural products (NPs) refer to the different kinds of small molecular-containing sulfur (S) elements. Sulfur-containing NPs tightly link to the biochemical processes and play an important role in the pharmaceutical industry. The majority of S-containing NPs are generally isolated from Alliaceae plants or bacteria, and those from fungi are still relatively rare. In recent years, an increasing number of S-containing metabolites have been discovered in marine and terrestrial fungi, but there is no comprehensive and targeted review to summarize the studies. In order to make it more straightforward to better grasp the fungal-derived S-containing NPs and understand the particularity of marine S-containing NPs compared to those from terrestrial fungi, we summarized the chemical structures and biological activities of 89 new fungal-derived S-containing metabolites from 1929 when the penicillin was discovered to the present in this current review. The structural and bioactive diversity of these S-containing metabolites were concluded in detail, and the preliminary mechanism for C-S bond formation in fungi was also discussed briefly.
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