Journal
MACROMOLECULES
Volume 55, Issue 23, Pages 10430-10438Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.macromol.2c01714
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Funding
- ESPCI Paris-PSL
- CNRS (Emergence @INC2019 grant)
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In this study, a novel thiazolidine-based polyacrylamide hydrogel with self-healing and shear-thinning behavior was synthesized. The hydrogel exhibited highly pH-dependent stability, making it a potential candidate for drug encapsulation and controlled release.
Self-healing, injectable, and responsive hydrogels are of increasing interest, particularly for biomedical applications. In this work, an original thiazolidine-based polyacrylamide hydrogel was synthesized via the condensation of two polyacrylamides carrying aldehyde and 1,2-aminothiol side groups, respectively. The hydrolytic stability and the viscoelastic properties of the hydrogel were investigated under acidic and physiological pHs. Rheological studies showed that the thiazolidine-based hydrogels exhibit dynamic properties resulting from the reversible formation of the thiazolidine linkages. Attractive self-healing ability and shear-thinning behavior were observed, rendering these hydrogels injectable through a needle. In addition, the hydrogels display a highly pH-dependent stability, making them potential candidates for drug encapsulation and controlled delivery.
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