Influence of the Surface Acidity of the Alumina on the Sustained Release of Ketoprofen

This work reports the immobilization of ketoprofen into mesoporous alumina, prepared in different way, to assess their possible applications as a matrix for controlled drug release. The acids' surface properties of the aluminas and their effect on the drug content and release rate were also analyzed. The systems have been characterized by powder X-ray diffractometry, Fourier transformer infrared spectroscopy (FT-IR), N-2 adsorption desorption, transmission electron microscopy, and FT-IR of pyridine adsorption. The results show that the drug is incorporated inside the pores of mesoporous alumina, and the content and release rate depend of surface acidity, when increase the surface acidity decrease the drug content and increase the release rate. (C) 2016 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.