Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 105, Issue 9, Pages 2940-2948Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.xphs.2015.12.026
Keywords
biomaterials; polymeric drug carrier; nanotechnology; materials science; bioavailability; gelatin; three-dimensional ordered macroporous; fenofibrate; sustained release; biodegradability
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In this study, a novel three-dimensional ordered macroporous gelatin (3DOMG) was fabricated as a carrier for increasing the solubility of poorly water-soluble drugs, offering sustained release and a high oral bioavailability. Polymethyl methacrylate nanospheres (257 nm) were used as a colloidal plastic framework to synthesize 3DOMG. Fenofibrate (FNB) was selected as a model drug and loaded onto 3DOMG by the adsorption equilibrium method. Detailed characterization showed that the FNB absorbed onto 3DOMG was in a microcrystalline state. A fluorescence experiment and the prepared drug microcrystal network gave further information on the physical state of the drug. A degradation experiment proved that 3DOMG was readily biodegradable. In vitro release testing showed that 3DOMG increased the dissolution rate of FNB and produced a sustained release. An in vivo pharmacokinetic study confirmed that 3DOMG improved the oral bioavailability compared with that of commercial sustained-release capsules. These findings confirm that 3DOMG can be regarded as a promising carrier for an oral drug delivery system. (C) 2016 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
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