Biomechanical forces in the aged brain: Relationship to AD

The pathogenesis of neurodegenerative disorders, including Alzheimer's disease, has been studied with a focus on biochemical mechanisms, such as the amyloid-beta plaque deposition and removal. Recently, the importance of brain microenvironmental cues, which comprise the sophisticated cellular and fluid system, has been emphasized in the aged brain or in pathological conditions. Especially, substrate rigidity and biomechanical forces of the brain microenvironment determine the function of glial cells and neurons; furthermore, these microenvironmental cues change with age. However, our understanding of role of the biomechanical cues on glial cells and neurons is relatively poor. In this review, we briefly introduce an overview of biomechanical forces that present in the aged brain and its sensations, and then examine the brain in Alzheimer's disease, which constitutes a representative neurodegenerative disorder, with regard to changes in the biomechanical forces associated with disease and aging.

Automated summary

This article focuses on the study of the pathogenesis of neurodegenerative disorders, particularly Alzheimer's disease. The biomechanical forces and substrate rigidity in the brain microenvironment change with age, affecting the function of glial cells and neurons. However, our understanding of the role of these biomechanical cues on glial cells and neurons is limited.