Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 130, Issue -, Pages 100-109Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2016.06.054
Keywords
Chiral separation; D-amino acid; Chromatography; Electrophoresis; Biological sample
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It is widely accepted that some of the free D-amino acids play important biological role. D-Aspartate and D-serine formed in the central nervous system of higher vertebrates have neurotransmitter/neuromodulator function. Together with D-alanine they are distributed in various tissues and biological fluids. Studying their physiological and pathological significance requires their sensitive and accurate determination in biological samples. The various separation and detection methods used for their analysis are overviewed in the present paper. Our focus is mainly the quantitative performance and the analysis of real biospecimens. (C) 2016 Elsevier B.V. All rights reserved.
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