☆ 4.8 Review

Asthma

LANCET (2023)

Related references

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Article Allergy

Baseline type 2 biomarker levels and response to tezepelumab in severe asthma

Jonathan Corren et al.

Summary: Tezepelumab significantly reduces T2 inflammatory biomarker levels and asthma exacerbation rates in patients with severe asthma. After 52 weeks of treatment, tezepelumab effectively reduces all measured biomarker levels and decreases asthma exacerbations.

ALLERGY (2022)

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Article Allergy

Perceptions of adolescents and young adults with allergy and/or asthma and their parents on EAACI guideline recommendations about transitional care: A European survey

Ekaterina Khaleva et al.

Summary: This study surveyed patients aged 11-25 with allergies and/or asthma and their parents across Europe, finding that the majority considered the transitional care recommendations important. However, there were conditional approvals for some recommendations.

ALLERGY (2022)

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Article Respiratory System

European Respiratory Society guidelines for the diagnosis of asthma in adults

Renaud Louis et al.

Summary: This article discusses the challenges faced in diagnosing asthma in adults and the recommendations provided by a taskforce set up by the European Respiratory Society. The taskforce emphasizes the importance of spirometry in the initial diagnosis and suggests further tests if obstruction is not detected. They also highlight the value of phenotyping and taking into account the patient's experience in the diagnostic process.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Respiratory System

The burden of asthma, hay fever and eczema in children in 25 countries: GAN Phase I study

Luis Garcia-Marcos et al.

Summary: This study aims to investigate the prevalence and severity of asthma, rhinoconjunctivitis, and eczema in school children worldwide. The results demonstrate significant variations in the burden of these diseases among the countries studied, with a considerable burden observed in all regions.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Letter Respiratory System

Pulse oximeter measurements vary across ethnic groups: an observational study in patients with COVID-19

Colin J. Crooks et al.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Critical Care Medicine

Reducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy: a multicentre, parallel, randomised, controlled, phase 3 trial

Steve Turner et al.

Summary: This study evaluated the efficacy of adding fractional exhaled nitric oxide (FeNO) to symptom-guided treatment in children with asthma. The results showed that the addition of FeNO did not reduce exacerbations in children prone to asthma exacerbation. Asthma symptoms remain the only tool for guiding treatment decisions.

LANCET RESPIRATORY MEDICINE (2022)

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Review Allergy

Difficult-to-Treat Asthma Management in School-Age Children

Andy Bush et al.

Summary: The World Health Organization categorizes severe asthma into three types and estimates the frequency of severe asthma in children. It is essential to carefully evaluate the diagnosis of asthma and utilize objective biomarkers to assess the pathophysiologic phenotypes of severe asthma. Children with difficult-to-treat asthma may require alternative treatment approaches, including asthma biologics. In addition to introducing new medications, advancements in digital health offer the opportunity for closer monitoring to improve treatment response and prevent severe asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

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Article Respiratory System

Holy Grail: the journey towards disease modification in asthma

William W. Busse et al.

Summary: Currently, there is no cure for asthma, and treatment focuses on preventing or reducing symptoms rather than addressing the underlying disease. Disease-modifying treatments have been investigated and approved for other indications but have proven more challenging in the heterogeneous nature of asthma. To explore the potential of disease-modifying treatment, considerations should be made in study design, such as selecting appropriate endpoints and trial length. Future focus areas for disease-modifying treatments in asthma may include early assessments, interventions for genetically susceptible patients, prevention of virally induced asthma, and therapies to promote a healthy microbiome.

EUROPEAN RESPIRATORY REVIEW (2022)

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Review Allergy

Managing the allergy and asthma epidemic in 2020s-Lessons from the Finnish experience

Tari Haahtela et al.

Summary: Finland implemented a systematic public health programme for a decade to reduce the burden of allergic disorders by revisiting prevention strategies. The programme emphasized on allergy health and the connection with the natural environment, improving allergy management practices. The results after ten years were favorable, with changes in healthcare practices, reduced disability among patients, and significant cost savings achieved.

ALLERGY (2022)

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Article Respiratory System

The burden of asthma, hay fever and eczema in adults in 17 countries: GAN Phase I study

Kevin Mortimer et al.

Summary: This study aims to fill the evidence gap regarding the burden of asthma, hay fever, and eczema in adults in multiple countries. The results show a substantial burden of these diseases, highlighting their major public health importance.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Review Allergy

Gene-environment interactions in childhood asthma revisited; expanding the interaction concept

Natalia Hernandez-Pacheco et al.

Summary: Investigation of gene-environment interactions in childhood asthma can provide important insights into the gene regulatory framework. However, traditional models have limitations in capturing the complexity of multiple exposures and genetic variants, thus expanding the concept by evaluating other omics layers and host factors is necessary.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2022)

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Article Respiratory System

Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide

Simon Couillard et al.

Summary: A risk scale predicting asthma attacks based on blood eosinophil count and exhaled nitric oxide (FeNO) was proposed, showing potential to predict and prevent asthma attacks through anti-inflammatory treatment.

THORAX (2022)

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Review Critical Care Medicine

FeNO in Asthma

Lola Loewenthal et al.

Summary: Asthma is a common disease impacting 350 million people globally, with FeNO testing providing a valuable tool for improving diagnosis, predicting response to treatment, monitoring adherence, and assessing asthma risk and progression.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Article Critical Care Medicine

Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene-environment interactions across the lifespan

Alva Agusti et al.

Summary: Recent research findings challenge the traditional view of chronic obstructive pulmonary disease (COPD) as solely caused by smoking in genetically susceptible individuals. Instead, COPD is now understood as the potential end result of gene-environment interactions accumulated over an individual's lifetime. Future research should aim to understand the dynamic interactions between genes and the environment by integrating information from basic and clinical omics with exposures over time. Additionally, COPD should be viewed as a clinical syndrome rather than a single disease.

LANCET RESPIRATORY MEDICINE (2022)

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Review Health Care Sciences & Services

Personalized Management of Patients with Chronic Rhinosinusitis with Nasal Polyps in Clinical Practice: A Multidisciplinary Consensus Statement

Eugenio De Corso et al.

Summary: Chronic rhinosinusitis (CRS) is a commonly occurring chronic inflammatory disease of the sinuses and nasal passages, with nasal polyps (CRSwNP) presenting in a significant proportion of CRS patients. A third of CRSwNP patients do not respond well to current standard treatments. Biologics are being explored as a potential treatment option for severe uncontrolled CRSwNP, but their place in the treatment algorithm is still being debated. Effective endotyping of CRSwNP patients is necessary to identify those who would benefit from biologics treatment. Other factors such as comorbidities including allergies, non-steroidal anti-inflammatory drug-exacerbated respiratory disease, and asthma also impact treatment decisions. While a multidisciplinary approach may improve CRSwNP management in patients with comorbidities, there is currently no shared management model.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Review Pediatrics

Allergies to food and airborne allergens in children and adolescents: role of epigenetics in a changing environment

Erik Melen et al.

Summary: This review discusses the impact of allergic diseases on children and adolescents globally, specifically focusing on allergies to food and airborne allergens, and provides examples of prevalence trends in the context of increasing climate change concerns. The profound environmental changes, such as loss of biodiversity, air pollution, and climate change, have been affecting natural systems. The potential links between these changes and allergic diseases in children are explored, along with their clinical implications. The review also discusses the correlation between relevant exposures for allergic diseases and epigenetic changes like DNA methylation, proposing that epigenetics could be a promising tool for capturing exposures and hazards related to a changing environment. Furthermore, it suggests that epigenetics might also provide promising biomarkers and help in understanding the mechanisms of allergic disease initiation and progression.

LANCET CHILD & ADOLESCENT HEALTH (2022)

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Article Respiratory System

Risk of osteoporosis and fragility fractures in asthma due to oral and inhaled corticosteroids: two population-based nested case-control studies

Christos Chalitsios et al.

Summary: Exposure to oral or inhaled corticosteroids is associated with bone health issues in asthma patients, with a dose-response relationship. It is recommended to administer steroids at the lowest possible level to maintain asthma control.

THORAX (2021)

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Article Critical Care Medicine

Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial

Liam G. Heaney et al.

Summary: The study compared a biomarker-based treatment adjustment strategy with a symptom-risk-based algorithm in severe asthma patients, finding that the biomarker strategy resulted in a higher proportion of patients reducing corticosteroid dose. Understanding patient non-compliance with treatment advice is an important area for future research. The prevalence of T2 biomarker-low severe asthma was found to be low.

LANCET RESPIRATORY MEDICINE (2021)

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Article Allergy

The Prevalence of Subtypes of Type 2 Inflammation in an Unselected Population of Patients with Severe Asthma

Laurits Frossing et al.

Summary: This study examined the expression levels of T2 inflammatory markers in patients with severe asthma and their relationship with clinical characteristics and comorbidities. The majority of patients exhibited at least one T2 inflammatory trait, and the coexpression of T2 biomarkers showed high heterogeneity with distinct clinical characteristics.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Article Critical Care Medicine

Use of Fractional Exhaled Nitric Oxide to Guide the Treatment of Asthma An Official American Thoracic Society Clinical Practice Guideline

Sumita B. Khatri et al.

Summary: The FENO test is a useful tool in assessing asthma patients, and based on the latest evidence a recommendation has been made that using FENO in patients under consideration for treatment may be beneficial and should be used in conjunction with standard care.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Review Critical Care Medicine

Severe Adult Asthmas: Integrating Clinical Features, Biology, and Therapeutics to Improve Outcomes

Sally E. Wenzel

Summary: Evaluation and management of severe asthma remains a core focus in pulmonary practice. Advances in clinical phenotyping and molecular tools have greatly enhanced our understanding and treatment of severe asthma. Challenges still exist, but conceptual understanding of the disease has evolved significantly in a relatively short period of time.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Respiratory System

A randomised controlled trial of the effect of a connected inhaler system on medication adherence in uncontrolled asthmatic patients

Alison Moore et al.

Summary: This study evaluated the effect of a connected inhaler system on adherence to asthma maintenance therapy, finding that feedback data and increasing patients' use of maintenance medication can improve adherence and reduce the use of rescue medication in patients with uncontrolled asthma.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Critical Care Medicine

Balancing the needs of the many and the few: where next for adult asthma guidelines?

Dominick Shaw et al.

Summary: Asthma management is predominantly done in non-specialist settings, with traditional approaches based on population-based generalizations often proving ineffective. A new combined approach, focusing on treatable mechanistic traits, is recommended to improve outcomes.

LANCET RESPIRATORY MEDICINE (2021)

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Article Critical Care Medicine

Recurrent Severe Preschool Wheeze: From Prespecified Diagnostic Labels to Underlying Endotypes

Polly F. M. Robinson et al.

Summary: The study identified four clusters of severe preschool wheeze, distinguished by sensitization, peripheral eosinophilia, lower airway neutrophilia, and bacteriology. Blood tests and pathogen distribution showed significant differences among different pathological clusters.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Respiratory System

European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years

Erol A. Gaillard et al.

Summary: This study introduces evidence-based clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years, recommending spirometry, bronchodilator reversibility testing, and exhaled nitric oxide fraction as first-line diagnostic tests, and advising against diagnosing asthma in children based solely on clinical history or a single abnormal test result.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Review Medicine, General & Internal

Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma A Systematic Review and Meta-analysis

Lisa H. Y. Kim et al.

Summary: The systematic synthesis of outcomes from 20 randomized clinical trials revealed that triple therapy (ICS, LABA, and LAMA) was significantly associated with reduced risk of severe asthma exacerbations and modest improvements in asthma control compared to dual therapy (ICS plus LABA), with no significant differences in quality of life or mortality.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Medicine, General & Internal

Analysis of Discrepancies Between Pulse Oximetry and Arterial Oxygen Saturation Measurements by Race and Ethnicity and Association With Organ Dysfunction and Mortality

An-Kwok Ian Wong et al.

Summary: This study examined racial and ethnic differences in oxygen saturation levels between Spo(2) and Sao(2) measurements, and found that patients with hidden hypoxemia had higher organ dysfunction scores and higher in-hospital mortality rates after arterial blood gas testing.

JAMA NETWORK OPEN (2021)

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Review Cardiac & Cardiovascular Systems

Corticosteroids and bone health in people with asthma: A systematic review and meta-analysis

Christos Chalitsios et al.

Summary: This study found that in patients with asthma, the use of oral corticosteroids (OCS) and high-dose inhaled corticosteroids (ICS) increases the risk of osteoporosis and fractures. Therefore, it is important to carefully balance the efficacy and safety of treatment in asthma to improve patients' quality of life.

RESPIRATORY MEDICINE (2021)

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Article Respiratory System

A low exhaled nitric oxide level excludes a short-term benefit from inhaled corticosteroids in suspected asthma: A randomized placebo-controlled trial

Lissa Sutherland et al.

Summary: The study suggests that steroid-naive patients with symptoms suggestive of asthma and an FeNO <= 27 ppb are unlikely to benefit from initiating treatment with an ICS over 3 months. Further research is recommended to confirm these findings before withholding ICS treatment.

RESPIROLOGY (2021)

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Review Allergy

Airway smooth muscle pathophysiology in asthma

Blanca Camoretti-Mercado et al.

Summary: Airway smooth muscle (ASM) cells play a central role in the pathogenesis of asthma, controlling muscle tone and participating in airway hyperresponsiveness and inflammation. Therapeutic approaches for asthma require a comprehensive understanding of ASM structure and function.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Physiology

Airway Sensory Nerve Plasticity in Asthma and Chronic Cough

Matthew G. Drake et al.

Summary: Recent advancements in studying airway sensory nerves have revealed their heterogeneity and potential roles in respiratory diseases like asthma and chronic cough, leading to emerging treatments targeting these nerves for therapeutic implications.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Allergy

Asthma Phenotyping in Primary Care: Applying the International Severe Asthma Registry Eosinophil Phenotype Algorithm Across All Asthma Severities

Marjan Kerkhof et al.

Summary: The study found that the eosinophilic asthma phenotype predominates in primary care in the UK, and is associated with greater asthma severity and healthcare resource use. These patients may benefit from earlier and targeted asthma therapy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Review Allergy

Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD

Meghan D. Althoff et al.

Summary: Asthma is a complex disease with heterogeneous phenotypes and endotypes. Common comorbidities such as obesity, obstructive sleep apnea, and gastroesophageal reflux disease may share inflammatory pathways and worsen asthma control.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Article Respiratory System

Clinical value of bronchodilator response for diagnosing asthma in steroid-naive adults

Leena E. Tuomisto et al.

Summary: This study evaluated the sensitivity of using BDR in FEV1 as a diagnostic test for asthma in newly diagnosed steroid-naive adult patients, finding that the current BDR threshold has low diagnostic sensitivity for asthma. In obstructive patients, sensitivity is somewhat higher but still far from optimal, indicating the need for confirmation with other lung function tests.

ERJ OPEN RESEARCH (2021)

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Review Allergy

The Management of Extrapulmonary Comorbidities and Treatable Traits; Obesity, Physical Inactivity, Anxiety, and Depression, in Adults With Asthma

Rebecca F. McLoughlin et al.

Summary: Asthma is a complex disease with variable expression and severity, often accompanied by multiple comorbidities and treatable traits. Extrapulmonary traits in asthma patients can have an impact on future outcomes and management, requiring targeted treatment interventions.

FRONTIERS IN ALLERGY (2021)

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Article Respiratory System

Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes

Eleni Papakonstantinou et al.

Summary: Bronchial thermoplasty improves asthma control, reduces airway smooth muscle, and promotes epithelial cell proliferation. It has distinct effects on different asthma endotypes/phenotypes, indicating that its benefits are achieved through diverse molecular targets associated with asthma endotypes/phenotypes.

RESPIRATORY RESEARCH (2021)

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Article Respiratory System

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children

Alyn H. Morice et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Review Allergy

Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence

Jean Bousquet et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Review Allergy

Asthma-COPD Overlap and Chronic Airflow Obstruction: Definitions, Management, and Unanswered Questions

Stephen Milne et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Article Respiratory System

Overuse of short-acting β2-agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA programme

Bright I. Nwaru et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Article Respiratory System

Targeting treatable traits in severe asthma: a randomised controlled trial

Vanessa M. McDonald et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Review Immunology

Asthma epidemiology and risk factors

Jessica Stern et al.

SEMINARS IN IMMUNOPATHOLOGY (2020)

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Review Allergy

Epithelial cell dysfunction, a major driver of asthma development

Irene H. Heijink et al.

ALLERGY (2020)

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Article Respiratory System

Age-specific incidence of allergic and non-allergic asthma

Johanna Pakkasela et al.

BMC PULMONARY MEDICINE (2020)

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Bidirectional interaction of airway epithelial remodeling and inflammation in asthma

Asoka Banno et al.

CLINICAL SCIENCE (2020)

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Letter Respiratory System

Airway abundance of Haemophilus influenzae predicts response to azithromycin in adults with persistent uncontrolled asthma

Steven L. Taylor et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Editorial Material Respiratory System

FENO as a biomarker guide for inhaled corticosteroid step down in patients with mild-to-moderate well-controlled asthma

Anh Tuan Dinh-Xuan et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Review Pharmacology & Pharmacy

Association between adherence and severe asthma exacerbation: A systematic review and meta-analysis

Bunchai Chongmelaxme et al.

JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION (2020)

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Article Medicine, Research & Experimental

Asthma-Related Health Outcomes Associated with Short-Acting β2-Agonist Inhaler Use: An Observational UK Study as Part of the SABINA Global Program

Chloe I. Bloom et al.

ADVANCES IN THERAPY (2020)

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Review Respiratory System

Anti-alarmins in asthma: targeting the airway epithelium with next-generation biologics

Celeste M. Porsbjerg et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Article Critical Care Medicine

Advances in understanding and reducing the burden of severe asthma in children

Marielle W. Pijnenburg et al.

LANCET RESPIRATORY MEDICINE (2020)

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Review Allergy

Assessment and Management of Occupational Asthma

Paul Cullinan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Paucigranulocytic asthma: Uncoupling of airway obstruction from inflammation

Omar Tliba et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Review Allergy

What did we learn from multiple omics studies in asthma?

Olga Ivanova et al.

ALLERGY (2019)

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Review Immunology

The Cytokines of Asthma

Bart N. Lambrecht et al.

IMMUNITY (2019)

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Article Cardiac & Cardiovascular Systems

Increase in blood eosinophils during follow-up is associated with lung function decline in adult asthma

Sophie Graff et al.

RESPIRATORY MEDICINE (2019)

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Article Cardiac & Cardiovascular Systems

Age- and gender-specific incidence of new asthma diagnosis from childhood to late adulthood

Jasmin Honkamaki et al.

RESPIRATORY MEDICINE (2019)

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Article Critical Care Medicine

Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies

Milton Pividori et al.

LANCET RESPIRATORY MEDICINE (2019)

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Article Critical Care Medicine

Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Nonadherence in Severe Asthma

Liam G. Heaney et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Mast Cell-Mediated Orchestration of the Immune Responses in Human Allergic Asthma: Current Insights

Daniel Elieh Ali Komi et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2019)

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Review Respiratory System

Immediate bronchodilator response in FEV1 as a diagnostic criterion for adult asthma

Leena E. Tuomisto et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

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Article Respiratory System

Asthma admission rates and patterns of salbutamol and inhaled corticosteroid prescribing in England from 2013 to 2017

Sherif Gonem et al.

THORAX (2019)

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Article Genetics & Heredity

Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

Manuel A. R. Ferreira et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2019)

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Article Critical Care Medicine

Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma

Steven L. Taylor et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Letter Respiratory System

Suppression of FENO with observed inhaled corticosteroid therapy in severe asthma: is it a useful test in clinical practice?

Shoaib Faruqi et al.

ERJ OPEN RESEARCH (2019)

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Review Public, Environmental & Occupational Health

The Global Impact of Asthma in Adult Populations

Oladunni Enilari et al.

ANNALS OF GLOBAL HEALTH (2019)

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Review Critical Care Medicine

Underdiagnosis and Overdiagnosis of Asthma

Shawn D. Aaron et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Epigenetics of Mucus Hypersecretion in Chronic Respiratory Diseases

Tara V. Saco et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

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Review Respiratory System

Airway remodeling in asthma: update on mechanisms and therapeutic approaches

Louis-Philippe Boulet

CURRENT OPINION IN PULMONARY MEDICINE (2018)

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Article Medicine, General & Internal

Inhaled Combined Budesonide-Formoterol as Needed in Mild Asthma

Paul M. O'Byrne et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Medicine, General & Internal

As-Needed Budesonide-Formoterol versus Maintenance Budesonide in Mild Asthma

Eric D. Bateman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Review Respiratory System

Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils): a systematic review and meta-analysis

Helen L. Petsky et al.

THORAX (2018)

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Article Respiratory System

Nerve ablation after bronchial thermoplasty and sustained improvement in severe asthma

N. Facciolongo et al.

BMC PULMONARY MEDICINE (2018)

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Review Allergy

The interplay between neuroendocrine activity and psychological stress-induced exacerbation of allergic asthma

Tomomitsu Miyasaka et al.

ALLERGOLOGY INTERNATIONAL (2018)

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Article Critical Care Medicine

Fractional exhaled nitric oxide as a predictor of response to inhaled corticosteroids in patients with non-specific respiratory symptoms and insignificant bronchodilator reversibility: a randomised controlled trial

David B. Price et al.

LANCET RESPIRATORY MEDICINE (2018)

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Article Cell Biology

Eosinophils increase airway sensory nerve density in mice and in human asthma

Matthew G. Drake et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Respiratory System

ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing

Teal S. Hallstrand et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

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Article Cardiac & Cardiovascular Systems

Differentiation of adult severe asthma from difficult-to-treat asthma - Outcomes of a systematic assessment protocol

Anna von Bulow et al.

RESPIRATORY MEDICINE (2018)

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Article Multidisciplinary Sciences

NSAIDs-hypersensitivity often induces a blended reaction pattern involving multiple organs

Inmaculada Dona et al.

SCIENTIFIC REPORTS (2018)

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Article Environmental Sciences

The Melbourne epidemic thunderstorm asthma event 2016: an investigation of environmental triggers, effect on health services, and patient risk factors

Francis Thien et al.

LANCET PLANETARY HEALTH (2018)

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Review Respiratory System

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Celeste Porsbjerg et al.

EUROPEAN CLINICAL RESPIRATORY JOURNAL (2018)

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Article Respiratory System

The Economic Burden of Asthma in the United States, 2008-2013

Tursynbek Nurmagambetov et al.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2018)

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Review Respiratory System

Accuracy of FENO for diagnosing asthma: a systematic review

Stefan Karrasch et al.

THORAX (2017)

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Article Respiratory System

Inducible laryngeal obstruction: an official joint European Respiratory Society and European Laryngological Society statement

Thomas Halvorsen et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

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Article Respiratory System

ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests

Allan L. Coates et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

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Article Medicine, General & Internal

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial

Peter G. Gibson et al.

LANCET (2017)

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Article Cardiac & Cardiovascular Systems

The impact of dysfunctional breathing on the assessment of asthma control

Sandra Veidal et al.

RESPIRATORY MEDICINE (2017)

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Article Critical Care Medicine

Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

Joan B. Soriano et al.

LANCET RESPIRATORY MEDICINE (2017)

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Review Critical Care Medicine

Asthma transition from childhood into adulthood

Oliver Fuchs et al.

LANCET RESPIRATORY MEDICINE (2017)

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Article Allergy

Identifying Risk of Future Asthma Attacks Using UK Medical Record Data: A Respiratory Effectiveness Group Initiative

John D. Blakey et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2017)

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Review Immunology

Effectiveness of Influenza Vaccines in Asthma: A Systematic Review and Meta-Analysis

Eleftheria Vasileiou et al.

CLINICAL INFECTIOUS DISEASES (2017)

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Article Respiratory System

Is it possible to claim or refute sputum eosinophils ≥ 3% in asthmatics with sufficient accuracy using biomarkers?

Sophie F. Demarche et al.

RESPIRATORY RESEARCH (2017)

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Review Medicine, General & Internal

Systematic meta-review of supported selfmanagement for asthma: a healthcare perspective

Hilary Pinnock et al.

BMC MEDICINE (2017)

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Article Allergy

Heritability and confirmation of genetic association studies for childhood asthma in twins

V. Ullemar et al.

ALLERGY (2016)

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Article Medicine, General & Internal

Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma A Randomized Clinical Trial

J. Christian Virchow et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

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Article Pediatrics

Preventing Exacerbations in Preschoolers With Recurrent Wheeze: A Meta-analysis

Sunitha V. Kaiser et al.

PEDIATRICS (2016)

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Article Respiratory System

Identifying patients at risk for severe exacerbations of asthma: development and external validation of a multivariable prediction model

Rik J. B. Loymans et al.

THORAX (2016)

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Article Critical Care Medicine

Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies

Hector G. Ortega et al.

LANCET RESPIRATORY MEDICINE (2016)

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Review Immunology

The immunology of asthma

Bart N. Lambrecht et al.

NATURE IMMUNOLOGY (2015)

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Article Respiratory System

Inhaled corticosteroids in COPD: the clinical evidence

Pierre Ernst et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

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Article Multidisciplinary Sciences

Impact of Inhaled Corticosteroids on Growth in Children with Asthma: Systematic Review and Meta-Analysis

Yoon Kong Loke et al.

PLOS ONE (2015)

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Article Respiratory System

Diagnostic work-up in patients with possible asthma referred to a university hospital

Vibeke Backer et al.

EUROPEAN CLINICAL RESPIRATORY JOURNAL (2015)

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Review Allergy

Defining and managing risk in asthma

J. D. Blakey et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2014)

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Article Respiratory System

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

Kian Fan Chung et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

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Article Allergy

Standardized quality (SQ) house dust mite sublingual immunotherapy tablet (ALK) reduces inhaled corticosteroid use while maintaining asthma control: A randomized, double-blind, placebo-controlled trial

Holger Mosbech et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Article Respiratory System

The association between childhood asthma and adult chronic obstructive pulmonary disease

Andrew Tai et al.

THORAX (2014)

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Article Allergy

Short-Acting β-Agonist Use As a Marker of Current Asthma Control

Mitesh Patel et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2013)

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Editorial Material Critical Care Medicine

Health Disparities in Asthma

Erick Forno et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

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Review Biochemistry & Molecular Biology

The airway epithelium in asthma

Bart N. Lambrecht et al.

NATURE MEDICINE (2012)

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Article Medicine, General & Internal

Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy

Huib A. M. Kerstjens et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Article Critical Care Medicine

An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications

Raed A. Dweik et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

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Article Respiratory System

Individual-level socioeconomic status is associated with worse asthma morbidity in patients with asthma

Simon L. Bacon et al.

RESPIRATORY RESEARCH (2009)

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Article Critical Care Medicine

Cluster analysis and clinical asthma phenotypes

Pranab Haldar et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)

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Article Cardiac & Cardiovascular Systems

Outcome and severity of adult onset asthma -: Report from the obstructive lung disease in northern Sweden studies (OLIN)

Eva Ronmark et al.

RESPIRATORY MEDICINE (2007)

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Article Critical Care Medicine

The use of exhaled nitric oxide to guide asthma management - A randomized controlled trial

Dominick E. Shaw et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)

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Review Allergy

Severe asthma in adults: What are the important questions?

Pascal Chanez et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)

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Article Medicine, General & Internal

Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood:: ISAAC Phases One and Three repeat multicountry cross-sectional surveys

M. Innes Asher et al.

LANCET (2006)

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Article Allergy

Modifiable barriers to adherence to inhaled steroids among adults with asthma: It's not just black and white

AJ Apter et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2003)

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Article Allergy

Incidence and remission of asthma: A retrospective study on the natural history of asthma in Italy

R de Marco et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2002)

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Article Medicine, General & Internal

Mast-cell infiltration of airway smooth muscle in asthma

CE Brightling et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

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Article Critical Care Medicine

A comparison of the validity of different diagnostic tests in adults with asthma

CJ Hunter et al.

CHEST (2002)

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Article Critical Care Medicine

The risk of hospitalization and near fatal and fatal asthma in relation to the perception of dyspnea

R Magadle et al.

CHEST (2002)

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Review Respiratory System

Eosinophilic bronchitis: clinical manifestations and implications for treatment

PG Gibson et al.

THORAX (2002)

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