Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 129, Issue -, Pages 219-223Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2016.07.006
Keywords
Auraptene; Boropinic acid; Ferulic acid; 4 '-Geranyloxyferulic acid; Propolis; Umbelliferone
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Funding
- University G. D'Annunzio of Chieti-Pescara (Fondi FAR)
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In this paper the presence of selected prenylated and unprenylated phenylpropanoids, namely ferulic acid 1, boropinic acid 2, 4'-geranyloxyferulic acid 3, umbelliferone 4, 7-isopentenyloxycoumarin 5, and auraptene 6, have been determined in Italian raw propolis after having been extracted with different methodologies. An aqueous solution of beta-cyclodextrin was the best extraction method for ferulic acid 1, treatment with indifferently EtOH or aqueous beta-cyclodextrin were the most effective one for umbelliferone 4, boropinic acid 2 gave the best yields either with H2O/beta-cyclodextrin or olive oil treatment or in biphasic systems, maceration with biphasic mixtures of aqueous beta-cyclodextrin and olive oil was seen to be the most effective procedure for 7-isopentenyloxycoumarin 5, the only method providing significant quantities of 4'-geranyloxyferulic acid 3 was the maceration of raw propolis with olive oil, and finally auraptene 4 was best extracted with absolute EtOH. Classic maceration in general performed better than ultrasound-assisted one. (C) 2016 Elsevier B.V. All rights reserved.
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