Distribution of enrofloxacin within the bronchoalveolar region of healthy pigs

This study aimed to elucidate the distribution of enrofloxacin (ERFX) within the bronchoalveolar region of pigs. Six clinically healthy pigs were allocated to intramuscular treatments with either a single dose of 5 mg/kg or 7.5 mg/kg ERFX. Samples of plasma and bronchoalveolar lavage fluid (BALF) were obtained from each pig 0 (before administration), 3, 8, and 24 hr after ERFX administration. The ERFX concentrations in pulmonary epithelial lining fluid (ELF) and BALF cells showed a similar pattern during the experimental period, whereby ERFX concentrations in both ELF and BALF cells were higher than those in the plasma. These results suggest that intramuscularly injected ERFX is well-distributed in the bronchoalveolar region.

Automated summary

This study aimed to investigate the distribution of enrofloxacin (ERFX) in the bronchoalveolar region of pigs. Six healthy pigs were treated with either a single dose of 5 mg/kg or 7.5 mg/kg ERFX. Samples of plasma and bronchoalveolar lavage fluid (BALF) were collected at different time points. The results showed that ERFX concentrations in pulmonary epithelial lining fluid (ELF) and BALF cells were higher than those in the plasma, indicating a good distribution of intramuscularly injected ERFX in the bronchoalveolar region.