A numerical investigation of the mechanics of intracranial aneurysms walls: Assessing the influence of tissue hyperelastic laws and heterogeneous properties on the stress and stretch fields

Numerical simulations have been extensively used in the past two decades for the study of intracranial aneurysms (IAs), a dangerous disease that occurs in the arteries that reach the brain and affect overall 3.2% of a population without comorbidity with up to 60% mortality rate, in case of rupture. The majority of those studies, though, assumed a rigid-wall model to simulate the blood flow. However, to also study the mechanics of IAs walls, it is important to assume a fluid-solid interaction (FSI) modeling. Progress towards more reliable FSI simulations is limited because FSI techniques pose severe numerical difficulties, but also due to scarce data on the mechanical behavior and material constants of IA tissue. Additionally, works that have investigated the impact of different wall modeling choices for patient-specific IAs geometries are a few and often with limited conclusions. Thus our present study investigated the effect of different modeling approaches to simulate the motion of an IA. We used three hyperelastic laws - the Yeoh law, the three-parameter Mooney-Rivlin law, and a Fung-like law with a single parameter - and two different ways of modeling the wall thickness and tissue mechanical properties - one assumed that both were uniform while the other accounted for the heterogeneity of the wall by using a hemodynamics-drivenapproach in which both thickness and material constants varied spatially with the cardiac-cycle-averaged hemodynamics. Pulsatile numerical simulations, with patient-specific vascular geometries harboring IAs, were carried out using the one-way fluid-solid interaction solution strategy implemented in solids4foam, an extension of OpenFOAM (R), in which the blood flow is solved and applied as the driving force of the wall motion. We found that different wall morphology models yield smaller absolute differences in the mechanical response than different hyperelastic laws. Furthermore, the stretch levels of IAs walls were more sensitive to the hyperelastic and material constants than the stress. These findings could be used to guide modeling decisions on IA simulations, since the computational behavior of each law was different, for example, with the Yeoh law being the fastest to converge.

Automated summary

This study investigated the effect of different modeling approaches on simulating the motion of an intracranial aneurysm (IA), finding that different wall morphology models yield smaller absolute differences in the mechanical response than different hyperelastic laws. The stretch levels of IA walls were more sensitive to the hyperelastic and material constants than the stress. These findings can guide modeling decisions for IA simulations, as each hyperelastic law had a different computational behavior.