4.7 Article

Protein Carbamylation and the Risk of ESKD in Patients with CKD

Related references

Note: Only part of the references are listed.
Article Transplantation

Protein carbamylation and chronic kidney disease progression in the Chronic Renal Insufficiency Cohort Study

Sahir Kalim et al.

Summary: The study suggests that protein carbamylation is a predictor of CKD progression beyond traditional risk factors like eGFR and proteinuria. However, the association of carbamylation with mortality was weaker in this limited sample size.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

Editorial Material Transplantation

New clinical evidence for urea toxicity

Vincent Verdier et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

Article Urology & Nephrology

Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease

Vera Jankowski et al.

Summary: Sortilin carbamylation is associated with cardiovascular calcification in patients with chronic kidney disease (CKD). Carbamylated sortilin alters ligand binding and accelerates vascular calcification. Patients with carbamylated sortilin exhibit faster progression of coronary artery calcification. Therefore, carbamylated sortilin may be an important risk factor for cardiovascular complications in CKD patients.

KIDNEY INTERNATIONAL (2022)

Article Medicine, General & Internal

Association of Estimated GFR Calculated Using Race-Free Equations With Kidney Failure and Mortality by Black vs Non-Black Race

Orlando M. Gutierrez et al.

Summary: This retrospective analysis compared the racial differences in risk of KFRT and mortality between Black and non-Black participants with kidney disease. The study found that the eGFR equation that included both creatinine and cystatin C without considering race demonstrated racial differences in risk across the range of eGFR. The eGFRcr-cys equation may be preferable for assessing racial differences in the risk of KFRT and mortality associated with low eGFR.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

Review Urology & Nephrology

Systematic Review and Meta-Analysis of Plasma and Urine Biomarkers for CKD Outcomes

Caroline Liu et al.

Summary: Sensitive and specific biomarkers are needed to better understand the risk of incident and progressive CKD. A systematic review and meta-analysis were conducted to assess the prognostic value of preclinical plasma and urine biomarkers for CKD outcomes. The most frequently studied biomarkers (TNFR1, FGF23, TNFR2, KIM-1, suPAR, KIM-1, NGAL) showed significant associations with CKD outcomes. These findings suggest these biomarkers should be assessed in clinical practice.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

Review Biochemistry & Molecular Biology

Avenues for post-translational protein modification prevention and therapy

Mengyao Tang et al.

Summary: Non-enzymatic post-translational modifications (nPTMs) of proteins have emerged as novel risk factors for various diseases. Protein carbamylation and glycation are common nPTMs and potential therapeutic targets. Reducing the burden of these modifications is a promising therapeutic approach.

MOLECULAR ASPECTS OF MEDICINE (2022)

Article Urology & Nephrology

Carbamylation of Integrin αIIbβ3: The Mechanistic Link to Platelet Dysfunction in ESKD

Veronika Binder et al.

Summary: The study explored carbamylation as a potential mechanistic link between uremia and platelet dysfunction in patients with ESKD, revealing that carbamylation inhibited platelet activation, adhesion, and aggregation.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

Article Cardiac & Cardiovascular Systems

Circulating uromodulin inhibits vascular calcification by interfering with pro-inflammatory cytokine signalling

Ioana Alesutan et al.

Summary: The study found that uromodulin can reduce vascular calcification in CKD patients, possibly by interfering with cytokine-dependent pro-calcific signaling pathways. In CKD, decreased levels and carbamylation of uromodulin may contribute to vascular pathology.

CARDIOVASCULAR RESEARCH (2021)

Article Medicine, General & Internal

Race, Genetic Ancestry, and Estimating Kidney Function in CKD

C. Hsu et al.

Summary: The study found that using serum creatinine levels to estimate GFR without taking race (or genetic ancestry) into account led to systematic misclassification. Estimating GFR with cystatin C produced similar results while eliminating negative consequences of race-based approaches.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Carbamylation of elastic fibers is a molecular substratum of aortic stiffness

Manon Doue et al.

Summary: The study found that vascular elastic fibers can undergo carbamylation, leading to an increase in stiffness that may affect the mechanical properties of the vascular wall, thereby being associated with aortic stiffness and the development of cardiovascular diseases.

SCIENTIFIC REPORTS (2021)

Article Urology & Nephrology

Carbamylated Lipoproteins and Progression of Diabetic Kidney Disease

Kathryn C. B. Tan et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

Article Medicine, General & Internal

Association of Urinary Oxalate Excretion With the Risk of Chronic Kidney Disease Progression

Sushrut S. Waikar et al.

JAMA INTERNAL MEDICINE (2019)

Review Transplantation

Urea and chronic kidney disease: the comeback of the century? (in uraemia research)

Raymond Vanholder et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2018)

Article Transplantation

Nutritional therapy reduces protein carbamylation through urea lowering in chronic kidney disease

Biagio R. Di Iorio et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2018)

Article Endocrinology & Metabolism

Carbamylation is a competitor of glycation for protein modification in vivo

C. Nicolas et al.

DIABETES & METABOLISM (2018)

Article Urology & Nephrology

Protein carbamylation exacerbates vascular calcification

Daisuke Mori et al.

KIDNEY INTERNATIONAL (2018)

Review Urology & Nephrology

Mechanisms and consequences of carbamoylation

Sigurd Delanghe et al.

NATURE REVIEWS NEPHROLOGY (2017)

Article Multidisciplinary Sciences

Protein carbamylation is a hallmark of aging

Laetitia Gorissea et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Urology & Nephrology

Longitudinal Changes in Protein Carbamylation and Mortality Risk after Initiation of Hemodialysis

Sahir Kalim et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Article Urology & Nephrology

Ketoanalogue-Supplemented Vegetarian Very Low-Protein Diet and CKD Progression

Liliana Garneata et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Article Nutrition & Dietetics

The Effects of Parenteral Amino Acid Therapy on Protein Carbamylation in Maintenance Hemodialysis Patients

Sahir Kalim et al.

JOURNAL OF RENAL NUTRITION (2015)

Article Urology & Nephrology

Cause of Death in Patients with Reduced Kidney Function

Stephanie Thompson et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

Review Transplantation

Emerging role of post-translational modifications in chronic kidney disease and cardiovascular disease

Prathibha R. Gajjala et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2015)

Article Urology & Nephrology

Urea and Ammonia Metabolism and the Control of Renal Nitrogen Excretion

I. David Weiner et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

Article Urology & Nephrology

Protein Carbamylation Predicts Mortality in ESRD

Robert A. Koeth et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

Article Cell Biology

Carbamylation of Serum Albumin as a Risk Factor for Mortality in Patients with Kidney Failure

Anders H. Berg et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Urology & Nephrology

Estimating GFR Among Participants in the Chronic Renal Insufficiency Cohort (CRIC) Study

Amanda Hyre Anderson et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2012)

Article Medicine, General & Internal

Atherosclerosis in Chronic Kidney Disease: Lessons Learned from Glycation in Diabetes

Dilbahar S. Mohar et al.

MEDICAL CLINICS OF NORTH AMERICA (2012)

Article Medicine, General & Internal

A Predictive Model for Progression of Chronic Kidney Disease to Kidney Failure

Navdeep Tangri et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)

Article Physiology

Glycated and carbamylated albumin are more nephrotoxic than unmodified albumin in the amphibian kidney

M. -L. Gross et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2011)

Article Urology & Nephrology

Chronic Uremia Stimulates LDL Carbamylation and Atherosclerosis

Eugene O. Apostolov et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Article Medicine, General & Internal

Glycated Hemoglobin, Diabetes, and Cardiovascular Risk in Nondiabetic Adults.

Elizabeth Selvin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Hematology

Scavenger Receptors of Endothelial Cells Mediate the Uptake and Cellular Proatherogenic Effects of Carbamylated LDL

Eugene O. Apostolov et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)

Article Urology & Nephrology

Chronic Renal Insufficiency Cohort (CRIC) Study: Baseline Characteristics and Associations with Kidney Function

James P. Lash et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

Article Mathematical & Computational Biology

Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond

Michael J. Pencina et al.

STATISTICS IN MEDICINE (2008)

Article Biochemistry & Molecular Biology

Protein carbamylation links inflammation, smoking, uremia and atherogenesis

Zeneng Wang et al.

NATURE MEDICINE (2007)

Article Cardiac & Cardiovascular Systems

Modified LDLs induce proliferation-mediated death of human vascular endothelial cells through MAPK pathway

Eugene O. Apostolov et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

Article Medical Laboratory Technology

Global standardization of glycated hemoglobin measurement: the position of the IFCC Working Group

Andrea Mosca et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2007)