4.5 Article

Diabetes in intraductal papillary mucinous neoplasm of the pancreas and its association with malignancy

Journal

JOURNAL OF SURGICAL ONCOLOGY
Volume 127, Issue 4, Pages 625-632

Publisher

WILEY
DOI: 10.1002/jso.27142

Keywords

diabetes mellitus; dysplasia; intraductal papillary mucinous neoplasms; invasive carcinoma; pancreas

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Diabetes mellitus is associated with a higher risk of malignant intraductal papillary mucinous neoplasms, especially in patients with main pancreatic duct involvement.
BackgroundIntraductal papillary mucinous neoplasms (IPMNs) have the potential to become malignant. Few studies have focused on the prevalence of the diabetes mellitus (DM) in IPMNs and its association with malignancy. We evaluated the association between DM and malignant IPMNs in this study. MethodsA total of 226 patients with pathologically confirmed IPMNs were included. Demographic data, serum biochemical data, and imaging findings were collected. The malignant IPMNs were defined as those with high-grade dysplasia and associated invasive carcinoma. The association between DM and malignant IPMNs was studied using logistic regression analysis. ResultsThe prevalence of DM was 17.7% for all type IPMNs and 31.7% for malignant IPMNs. Compared to patients without DM, those with DM had a 3.6-fold (odds ratio [OR]: 3.62; 95% confidence interval [CI]: 1.26-10.44) higher risk of invasive carcinoma and 2.5-fold (OR: 2.48; 95% CI: 1.06-5.77) higher risk of malignant IPMNs. Similar results were observed in main pancreatic duct (MPD) involved IPMNs. New-onset DM was associated with a 4.13-fold (OR: 4.13, 95% CI: 1.27-13.36) higher risk of invasive carcinoma. ConclusionDM is associated with a higher risk of malignant IPMNs and invasive carcinoma, especially in patients with MPD-involved IPMNs.

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