Secondary thalamic atrophy related to brain infarction may contribute to post-stroke cognitive impairment

Background and purpose: The thalamus is a key brain hub that is globally connected to many cortical regions. Previous work highlights thalamic contributions to multiple cognitive functions, but few studies have measured thalamic volume changes or cognitive correlates. This study investigates associations between thalamic volumes and post-stroke cognitive function. Methods: Participants with non-thalamic brain infarcts (3-42 months) underwent MRI and cognitive testing. Focal infarcts and thalami were traced manually. In cases with bilateral infarcts, the side of the primary infarct volume defined the hemisphere involved. Brain parcellation and volumetrics were extracted using a standardized and previously validated neuroimaging pipeline. Age and gender-matched healthy controls provided normal comparative thalamic volumes. Thalamic atrophy was considered when the volume exceeded 2 standard deviations greater than the controls. Results: Thalamic volumes ipsilateral to the infarct in stroke patients (n=55) were smaller than left (4.4 +/- 1.4 vs. 5.4 +/- 0.5 cc, p < 0.001) and right (4.4 +/- 1.4 vs. 5.5 +/- 0.6 cc, p < 0.001) thalamic volumes in the controls. After controlling for head-size and global brain atrophy, infarct volume independently correlated with ipsilateral thalamic volume (beta= -0.069, p=0.024). Left thalamic atrophy correlated significantly with poorer cognitive performance (beta = 4.177, p = 0.008), after controlling for demographics and infarct volumes. Conclusions: Our results suggest that the remote effect of infarction on ipsilateral thalamic volume is associated with global post-stroke cognitive impairment (c) 2022 Elsevier Inc. All rights reserved.

Automated summary

This study investigates the associations between thalamic volumes and post-stroke cognitive function. The results show that the thalamic volumes on the affected side in stroke patients are smaller compared to the control group, and they are associated with cognitive impairment. These findings suggest that the remote effect of stroke on thalamic volume is correlated with global cognitive impairment.