Off the RADAR; questions regarding the trial protocol of a randomised controlled trial of antipsychotic reduction and discontinuation

The randomised controlled trial of antipsychotic reduction and discontinuation addresses essential questions with regard to continued use of antipsychotics in schizophrenia, pertaining to social functioning and continued antipsychotic use. However, significant methodological issues stated in the trial protocol have the potential to confound interpretation of any findings. These include use of a non-blinded outcome measure, treatment as usual comparator and possible sample size issues.

Automated summary

The randomised controlled trial examines the effects of reducing and discontinuing antipsychotics on social functioning and continued use in schizophrenia patients. However, methodological issues mentioned in the trial protocol could potentially impact the interpretation of the findings, such as non-blinded outcome measurement, treatment as usual comparator, and possible sample size problems.