Journal
JOURNAL OF PERINATOLOGY
Volume 36, Issue 6, Pages 427-431Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jp.2016.3
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OBJECTIVE: The objective of this study is to determine whether low-dose aspirin (LDA) reduced the rate of preterm birth (PTB) in a cohort of women at high risk for preeclampsia. STUDY DESIGN: Secondary analysis of the Maternal-Fetal Medicine Units High-Risk Aspirin trial. Preterm births were categorized by phenotype: indicated, spontaneous or due to preterm premature rupture of membranes (PPROMs). RESULTS: Of 1789 randomized women, 30.5% delivered before 37 weeks (18.5% indicated, 5.8% spontaneous and 6.2% following preterm PPROMs). Among women randomized to LDA, we observed a trend favoring fewer PTBs due to spontaneous preterm labor and preterm PPROMs, odds ratio (OR: 0.826 (0.620, 1.099)); the incidence of indicated PTBs appeared unchanged, OR: 0.999 (0.787, 1.268). CONCLUSION: Although not reaching significance, we observed an effect size similar to other studies of both low-and high-risk women. These results support findings from other studies assessing LDA as a PTB prevention strategy.
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