N-BOC protection of amines over mesoporous SBA-15 catalyst at room temperature

The role of mesoporous material for an efficient and simple protocol of Nitrogen protected tert-butoxycarbonyl (N-BOC) amines synthesis from various aromatic and aliphatic amines derivatives by using mesoporous SBA-15 catalyst under solvent free condition and without purification methodology is performed at room temperature. SBA-15 material was synthesized by hydrothermal method and characterizes the structure functionalities with X-ray diffraction, SEM, BET analysis and FT-IR spectroscopy to confirm the mesoporosity, morphology and functional groups and also surface area of catalyst respectively. X-ray profiles suggested that hexagonal structure with mesoporosity is obtained and even maintained even after regeneration of spent catalyst and well correlates with SEM analysis. This methodology provides one of the most straight forward syntheses of N-BOC amines from amines with 95-99% yields in short reaction interval. The catalyst is recovered and reused for the same protocol.

Automated summary

The mesoporous SBA-15 catalyst enables the direct synthesis of nitrogen-protected tert-butoxycarbonyl (N-BOC) amines with high yields under solvent free conditions and without purification, and the catalyst can be recovered and reused.