Visible-light-Induced synthesis of imidazolidines through formal [3+2] cycloaddition of aromatic imines with N,N,N', N'-tetramethyldiaminomethane

Imidazolidine is a saturated heterocycle with a cyclic aminal core that can be used to develop new pharmaco-logical drugs. Heteroleptic cyclometalated Ir(III) complex photosensitizers have been shown to enable the un-precedented synthesis of imidazolidines through a formal [3 + 2] photocycloaddition of aromatic imines with N, N,N',N'-tetramethyldiaminomethane. Herein, a reaction mechanism based on quenching experiments, quantum yield, ground-state redox potentials, and excited-state potentials is proposed.

Automated summary

In this study, a new method for synthesizing pharmacological drugs using a photosensitizer was proposed. The study showed that imidazolidines can be synthesized through a photocycloaddition reaction under specific conditions. A reaction mechanism was proposed based on quenching experiments, quantum yield, and potential measurements.