Total Syntheses of Iheyamines A and B

An efficient synthetic route to iheyamine A and its analogues was discovered; the crucial one-pot transformation included a C-C migration to form the characteristic seven -membered ring. Subsequent addition of acetone to iheyamine A initiated a cascade process to complete the total synthesis of iheyamine B.

Automated summary

An efficient synthetic route to iheyamine A and its analogues was discovered, involving a crucial one-pot transformation that included C-C migration to form the characteristic seven-membered ring. Subsequent addition of acetone to iheyamine A initiated a cascade process to complete the total synthesis of iheyamine B.