Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 88, Issue 1, Pages 690-700Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c02140
Keywords
-
Categories
Ask authors/readers for more resources
A variety of tetrahydro-5H-indolo[2,3-b]quinolines were efficiently synthesized through a copper(II)-catalyzed cascade reaction. This reaction involved double 1,4-additions and sequential intramolecular cyclization, and demonstrated broad substrate scope and scalability.
A variety of tetrahydro-5H-indolo[2,3-b]quinolines were prepared in 40-97% yields through a copper(II)-catalyzed cascade reaction of aza-o-quinone methides generated in situ from 2(chloromethyl)anilines and indoles. Experimental results showed that the reaction underwent double 1,4-additions and sequential intramolecular cyclization. The present method features broad substrate scope, good functional group tolerance, and easy gram scalable preparation of indolo[2,3-b]quinolines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available