Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids from Daphne pedunculata

From the whole plant of Daphne pedunculata, 12 macrocyclic daphnane diterpenoids, including six new compounds, daphnepedunins A-F (1-4, 9, and 10), were isolated. Their structures were elucidated by physiochemical and spectroscopic data analysis, the modified Mosher's method, and X-ray crystallography. The isolated compounds were evaluated for anti-HIV activity against HIV-1 infection in MT4 cells and showed significant anti-HIV activity with IC50 values of 36.3-994 nM. A consideration of the anti-HIV activity of these compounds provided further insight into the structure-activity relationships of macro-cyclic daphnane diterpenoids.

Automated summary

Twelve macrocyclic daphnane diterpenoids, including six new compounds, were isolated from the whole plant of Daphne pedunculata. Their structures were determined using various methods, and their anti-HIV activity was evaluated. The compounds showed significant activity against HIV, providing further insights into the structure-activity relationships of macrocyclic daphnane diterpenoids.