4.6 Article

Design, synthesis, molecular docking and antimicrobial activities of novel triazole-ferulic acid ester hybrid carbohydrates

Related references

Note: Only part of the references are listed.
Article Chemistry, Physical

Formazan analogous: Synthesis, antimicrobial activity, dihydrofolate reductase inhibitors and docking study

Abrar Bayazeed et al.

Summary: In this article, new formazan derivatives were synthesized and evaluated for their antimicrobial activity and minimum inhibitory concentration values. These derivatives showed promising antimicrobial activity against various bacterial and fungal strains, as well as inhibitory effects on specific enzymes.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Article Chemistry, Physical

Antimicrobial and in-silico evaluation of novel chalcone and amide-linked 1,4-disubstituted 1,2,3 triazoles

Manish Kumar Sharma et al.

Summary: This study reports the design, synthesis, spectral characterization, and antimicrobial evaluation of a series of chalcone-containing amide linked 1,4-disubstituted 1,2,3-triazole hybrids and their alkyne precursors. The hybrids exhibited lower minimum inhibitory concentration (MIC) values compared to their alkyne precursors, demonstrating synergistic antimicrobial effect. Docking and molecular dynamics studies supported the antimicrobial potential of these hybrids through various binding interactions.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Article Chemistry, Multidisciplinary

Auspicious water treatment approach. Oxidative degradation of fluconazole and voriconazole antibiotics by CrO3 in different acidic environments: Kinetics, mechanistic and thermodynamic modelling

Ahmed Fawzy et al.

Summary: The kinetics of oxidative degradation of two important triazole antibiotics, fluconazole (Flz) and voriconazole (Vcz), were investigated in sulfuric and perchloric acid environments using chromium (VI) oxide (Cr-VI). The degradation reactions were acid-catalyzed and exhibited first order kinetics with respect to [Cr-VI] and fractional-first orders with regard to [A] and [H+]. The rates of oxidative reactions were not significantly affected by the ionic strength and dielectric constants of the reaction media. No free radicals were detected during the degradation reactions. Heat and the addition of certain metal cations (Mg2+ & Ca2+) were found to enhance the degradation rates. The study proposed a plausible oxidative degradation mechanism consistent with the experimental results. The activation and thermodynamic parameters were calculated and discussed. This study presents a simple and promising procedure for the degradation of Flz and Vcz drugs and the transformation of highly toxic Cr(VI) oxide to a safe Cr-III compound, benefiting both the environment and human health.

JOURNAL OF SAUDI CHEMICAL SOCIETY (2022)

Article Chemistry, Multidisciplinary

Novel uracil derivatives depicted potential anticancer agents: In Vitro, molecular docking, and ADME study

Samar El-Kalyoubi et al.

Summary: A simple technique was used to synthesize various uracil derivatives, and their anticancer activity was evaluated. Compounds 6, 7, 15, and 16 showed strong cytotoxicity against multiple cancer cell lines and no toxicity against normal cells. Compound 7 exhibited high binding affinity with cyclin dependent kinase 2 and induced apoptosis in lung cancer cells.

ARABIAN JOURNAL OF CHEMISTRY (2022)

Review Medicine, Research & Experimental

Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives

Dan Li et al.

Summary: Ferulic acid, a phenolic substance widely found in plants, has been shown to have various biological activities such as antioxidative, anti-inflammatory, anti-apoptotic, and vascular protective effects. Its mechanisms of action involve inhibition of certain signaling pathways and enzymes related to oxidative stress, inflammation, and fibrosis.

LIFE SCIENCES (2021)

Review Chemistry, Medicinal

Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance

Harish C. Upadhyay

Summary: The widespread use of antibiotics has led to bacterial resistance and recurrent infections. To overcome this issue, multidrug therapy or single drugs acting on multiple targets may be utilized. Natural product-based hybrid molecules may provide a super alternative to combat drug resistance caused by various bacterial and fungal strains.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2021)

Review Chemistry, Medicinal

Recent Progress in 1H-1,2,3-triazoles as Potential Antifungal Agents

Nisha Poonia et al.

Summary: The increasing cases of antifungal resistance and the need to avoid side effects and drug interactions have led to a demand for expedited drug discovery and development of novel antifungals. 1,4-disubstituted 1,2,3-triazole, synthesized via CuAAC, has garnered interest for its broad chemotherapeutic potential. Recent advances in 1,2,3-triazole derivatives obtained by CuAAC may facilitate the development of triazole-based antifungal agents.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2021)

Review Chemistry, Medicinal

Triazole derivatives and their antiplasmodial and antimalarial activities

Xue-Mei Chu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Organic

Synthesis, antitubercular evaluation and molecular docking studies of phthalimide bearing 1,2,3-triazoles

Pramod S. Phatak et al.

SYNTHETIC COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview

Khurshed Bozorov et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2019)

Article Chemistry, Organic

Microwave synthesis, anti-oxidant and anti-tumor activity of some nucleosides derived 2-oxonicotinonitrile

Hassan A. El-Sayed et al.

SYNTHETIC COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Repositioning Salirasib as a new antimalarial agent

Exequiel O. J. Porta et al.

MEDCHEMCOMM (2019)

Review Pharmacology & Pharmacy

Ferulic Acid: A Promising Therapeutic Phytochemical and Recent Patents Advances

Ashun Chaudhary et al.

RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY (2019)

Article Chemistry, Medicinal

Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation

Hanane Kaoukabi et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Design, Synthesis, and Antifungal Activity of Novel Aryl-1,2,3-Triazole-β-Carboline Hybrids

Xin-Yu Huo et al.

MOLECULES (2018)

Article Biochemistry & Molecular Biology

Synthesis of 1H-1,2,3-triazole derivatives as new alpha-glucosidase inhibitors and their molecular docking studies

Satya Kumar Avula et al.

BIOORGANIC CHEMISTRY (2018)

Review Dermatology

Antioxidant Properties of Ferulic Acid and Its Possible Application

Kamila Zdunska et al.

SKIN PHARMACOLOGY AND PHYSIOLOGY (2018)

Article Chemistry, Multidisciplinary

Synthesis and Antimalarial Evaluation of [1,2,3]-Triazole-Tethered Sulfonamide-Berberine Hybrids

Neha Batra et al.

CHEMISTRYSELECT (2018)

Article Chemistry, Organic

Click Synthesis, Anticancer Activity and Molecular Docking Studies on Pyridazinone Scaffolds

Tamer El Malah et al.

CURRENT ORGANIC CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Design, synthesis, molecular-docking and antimycobacterial evaluation of some novel 1,2,3-triazolyl xanthenones

Gudikadi Linga Goud et al.

MEDCHEMCOMM (2017)

Article Immunology

Identification of Novel and Efficacious Chemical Compounds that Disturb Influenza A Virus Entry in vitro

Hany Khalil et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

Article Chemistry, Medicinal

Design, synthesis and in vitro anti-tuberculosis activity of benzo [6,7]cyclohepta[1,2-b]pyridine-1,2,3-triazole derivatives

Yasodakrishna Sajja et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Article Chemistry, Medicinal

1,2,3-Triazoles as Amide Bioisosteres: Discovery of a New Class of Potent HIV-1 Vif Antagonists

Idrees Mohammed et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Design, synthesis and antiproliferative activity studies of 1,2,3-triazole-chalcones

Dong-Jun Fu et al.

MEDCHEMCOMM (2016)

Review Biotechnology & Applied Microbiology

Mitigating risk in academic preclinical drug discovery

Jayme L. Dahlin et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Article Chemistry, Organic

Synthesis and antifungal activity of 1,2,3-triazole phenylhydrazone derivatives

Zhi-Cheng Dai et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

Article Chemistry, Medicinal

Synthesis of novel 1,2,3-triazole substituted-N-alky/aryl nitrone derivatives, their anti-inflammatory and anticancer activity

P. Sambasiva Rao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Click Reactions as a Key Step for an Efficient and Selective Synthesis of D-Xylose-Based ILs

Nadege Ferlin et al.

MOLECULES (2013)

Article Biochemistry & Molecular Biology

Synthesis of 1,2,3-triazole glycoconjugates as inhibitors of α-glucosidases

David R. da Rocha et al.

CARBOHYDRATE RESEARCH (2012)

Article Chemistry, Medicinal

Synthesis and Antimicrobial Activity of 1,2,3-Triazoles Containing Quinoline Moiety

V. Sumangala et al.

ARCHIVES OF PHARMACAL RESEARCH (2010)

Review Biochemistry & Molecular Biology

Antimicrobial natural products: an update on future antibiotic drug candidates

Muhammad Saleem et al.

NATURAL PRODUCT REPORTS (2010)

Article Chemistry, Medicinal

Synthesis, HIV-RT inhibitory activity and SAR of 1-benzyl-1H-1,2,3-triazole derivatives of carbohydrates

Fernando de C. da Silva et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility

Garrett M. Morris et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)

Review Plant Sciences

Synergism between natural products and antibiotics against infectious diseases

Shanmugam Hemaiswarya et al.

PHYTOMEDICINE (2008)

Article Biochemistry & Molecular Biology

Synthesis and antimicrobial activity of some cyclic and acyclic nucleosides of thieno[2,3-d]pyrimidines

Nasser A. Hassan et al.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2007)

Article Chemistry, Applied

Antioxidant activity of anacardic acids

I Kubo et al.

FOOD CHEMISTRY (2006)

Review Agriculture, Multidisciplinary

Ferulic acid: pharmaceutical functions, preparation and applications in foods

SY Ou et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2004)

Review Microbiology

Persistence of antibiotic resistant bacteria

DI Andersson

CURRENT OPINION IN MICROBIOLOGY (2003)

Article Multidisciplinary Sciences

Natural products and plant disease resistance

RA Dixon

NATURE (2001)

Review Microbiology

Antimicrobial use and bacterial resistance

S Monroe et al.

CURRENT OPINION IN MICROBIOLOGY (2000)