Fabrication of crosslinked piperazine polymer coating: Synthesis, characterization and its activity towards microorganisms

A simple, robust one step reaction for the preparation of hydrophilic crosslinked piperazine polymer is presented. The resulting crosslinked polymer was synthesized via solution polymerization technique and characterized using FTIR and NMR spectral studies ( 1 H NMR, 13 C NMR and DEPT-135). The thermal analysis of polymer was done using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) that exhibited glass transition temperature ( T g ) at110 degrees C. The molecular weight of the synthesized polymer was also determined using gel-permeation chromatography. The synthesized hydrophilic polymer exhibited excellent antimicrobial activity against Gram-negative bacteria ( Escherichia coli ), Grampositive bacteria ( Staphylococcus aureus ), Fungi ( Candida albicans ) and Tubercular variant ( Mycobacterium smegmatis ). The polymer was coated on glass slide and morphology of the coated surface was determined using scanning electron microscopy (SEM) and chemical stability of coated material in different pH values were tested.

Automated summary

A simple and robust one-step reaction for preparing hydrophilic crosslinked piperazine polymer is presented. The obtained polymer was synthesized via solution polymerization and characterized using FTIR and NMR spectroscopy. The synthesized polymer exhibited excellent antimicrobial activity against various bacteria and fungi. Further tests were conducted to evaluate the morphology and chemical stability of the coated material.