Synthesis and spectral characterization of some metal complexes with new heterocyclic azo imidazole dye ligand and study biological activity as anticancer

The complexation of Cu(II), Ag(I)and Au(III) ions studied with new synthesized azo imidazole ligand (ClPA1-MeI) which prepared by coupling reaction between 2-] 2 ' -(4 -Chloro Phenyl)azo [-1 -Methyl imidazole, whereas these compounds characterized by 1 H and 13 C-NMR, UV-Vis, Mass, Infrared spec-trum, SEM, X-ray diffraction studies and molar conductance. The studies show that the azo dye ligand has a tridentate structure and coordinates to the metal ion through the nitrogen atom of the azo group, which is the furthest away from the imidazole molecule, the nitrogen atom of the azomethine group of the heterocyclic imidazole ring, and the phenolic oxygen. Furthermore, MTT assays were used to test the anticancer properties of synthesized azo dye ligand and Au (III) complexes against brain cancer (A172) cell lines, and the results revealed that the prepared compounds exhibited good anticancer properties and are very promising candidates for future applications in anti-tumor drugs.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

In this study, the complexation of Cu(II), Ag(I), and Au(III) ions with a newly synthesized azo imidazole ligand was investigated. The compounds were characterized by various techniques, and their anticancer properties were evaluated. The results demonstrated that the synthesized compounds exhibited promising anticancer properties and could be potential candidates for future anti-tumor drug applications.