Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration

15-Prostaglandin dehydrogenase (15-PGDH) regulates the concentration of prostaglandin E2 in vivo. Inhibitors of 15-PGDH elevate PGE2 levels and promote tissue repair and regeneration. Here, we describe a novel class of quinoxaline amides that show potent inhibition of 15-PGDH, good oral bioavailability, and protective activity in mouse models of ulcerative colitis and recovery from bone marrow transplantation.

Automated summary

In this study, a novel class of quinoxaline amides was found to exhibit potent inhibition of 15-PGDH, resulting in elevated levels of PGE2 and promoting tissue repair and regeneration. These compounds also demonstrated good oral bioavailability and protective activity in mouse models of ulcerative colitis and recovery from bone marrow transplantation.