4.7 Article

New Dual P-Glycoprotein (P-gp) and Human Carbonic Anhydrase XII (hCA XII) Inhibitors as Multidrug Resistance (MDR) Reversers in Cancer Cells

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors

Chiara Testa et al.

Summary: This study reports the first Antibody-Drug-Conjugates (ADCs) containing human Carbonic Anhydrase (CA) directed Monoclonal Antibodies (MAbs) linked to low molecular weight inhibitors. The results show potent inhibition of tumor-associated CA enzymes and off-target human CA isoforms. These findings support the development of a novel class of ADCs for the treatment of chronic diseases such as cancer and inflammation.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies

Mateusz Kciuk et al.

Summary: Carbonic anhydrases IX and CAXII play crucial roles in cancer and have become a focus in anticancer drug design. This offers an opportunity to develop new targeted therapies with fewer side effects.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)

Review Cell & Tissue Engineering

Characteristics of the cancer stem cell niche and therapeutic strategies

Feng Ju et al.

Summary: This review summarizes the latest findings on the morphology, signaling pathways, and interactions of cancer stem cell (CSC) niches, as well as the genetic and epigenetic modulations involved in CSC maintenance. The crosstalk between CSCs and their niche plays a crucial role in therapy resistance and recurrence.

STEM CELL RESEARCH & THERAPY (2022)

Review Oncology

The multifaceted mechanisms of malignant glioblastoma progression and clinical implications

Rui Sun et al.

Summary: With the application of high throughput sequencing technologies at single-cell resolution, researchers have discovered immense cellular and tissue heterogeneity in the tumor microenvironment of glioblastoma. The interactions between malignant and immune cells generate an immunosuppressive microenvironment, while glioma stem cells play a critical role in tumor growth and therapeutic resistance.

CANCER AND METASTASIS REVIEWS (2022)

Article Oncology

Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer

Iris C. Salaroglio et al.

Summary: This study investigates the molecular mechanisms underlying the resistance of solid tumors to chemotherapy and immune-killing under intermittent hypoxia conditions. The researchers found that intermittent hypoxia significantly up-regulated the expression of ABCB1 and ABCC1, while down-regulating ABCA1, leading to chemo-immuno-resistance. Furthermore, they discovered that the activation of the HIF-1α/LAP axis, mediated by mitochondrial ROS, played a key role in this resistance. These findings provide new insights into the potential therapeutic targets for overcoming chemo-immuno-resistance in solid tumors.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Review Chemistry, Medicinal

Chemical molecular-based approach to overcome multidrug resistance in cancer by targeting P-glycoprotein (P-gp)

Hang Zhang et al.

Summary: This review highlights the recent achievements in drug design and mechanism studies of newly synthetic P-gp inhibitors in the past 5 years, which will help overcome multidrug resistance in cancer chemotherapy.

MEDICINAL RESEARCH REVIEWS (2021)

Review Pharmacology & Pharmacy

Hypoxia as a driver of resistance to immunotherapy

Joanna Kopecka et al.

Summary: Hypoxia in solid tumors leads to resistance to immunotherapy, particularly to ICPIs and CAR T-cells, by promoting immunosuppressive populations and angiogenesis. Innovative combination therapies may provide a solution to enhance the efficacy of immunotherapy against hypoxic and therapy-resistant tumors.

DRUG RESISTANCE UPDATES (2021)

Article Pharmacology & Pharmacy

Disruption of pH Dynamics Suppresses Proliferation and Potentiates Doxorubicin Cytotoxicity in Breast Cancer Cells

Diana Tavares-Valente et al.

Summary: The reverse pH gradient is a major feature associated with cancer cell reprogrammed metabolism and the generation of an acidic tumor microenvironment, contributing to drug resistance. Inhibiting the expression of pH regulators can reduce cancer cell aggressiveness and increase sensitivity to chemotherapy.

PHARMACEUTICS (2021)

Article Multidisciplinary Sciences

Tiliroside as a CAXII inhibitor suppresses liver cancer development and modulates E2Fs/Caspase-3 axis

Rui Han et al.

Summary: The study demonstrates that Tiliroside exerts a higher anti-proliferation effect on liver cancer cells compared to normal liver cells, with low toxicity, possibly by acting as a novel CAXII inhibitor.

SCIENTIFIC REPORTS (2021)

Review Oncology

The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: future opportunities for structure-based drug design of inhibitors

Jason Goebel et al.

Summary: The inhibitors of ABC transporters P-glycoprotein and ABCG2 were initially thought to be promising in overcoming multidrug resistance in cancer patients, but clinical trials have not been successful. Recent advances in structural biology have provided clearer insights into the mechanism of these transporters, which may lead to the development of more potent inhibitors.

CANCER DRUG RESISTANCE (2021)

Article Biochemistry & Molecular Biology

MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor

Chiara Riganti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Cell Biology

Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance

Dimas Carolina Belisario et al.

CELLS (2020)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers

Elisabetta Teodori et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Medicinal

Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment

Deepali Waghray et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Chemistry, Medicinal

Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018)

Alessio Nocentini et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2018)

Editorial Material Chemistry, Medicinal

Carbonic anhydrase inhibitors and their potential in a range of therapeutic areas

Claudiu T. Supuran

EXPERT OPINION ON THERAPEUTIC PATENTS (2018)

Review Pharmacology & Pharmacy

Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors

Claudiu T. Supuran

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2018)

Review Oncology

Revisiting the role of ABC transporters in multidrug-resistant cancer

Robert W. Robey et al.

NATURE REVIEWS CANCER (2018)

Review Biochemistry & Molecular Biology

Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX

Paul C. McDonald et al.

METABOLITES (2018)

Review Chemistry, Medicinal

Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer

Prashant Joshi et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Genetics & Heredity

Carbonic anhydrase XII functions in health and disease

Abdul Waheed et al.

Review Biochemistry & Molecular Biology

How many carbonic anhydrase inhibition mechanisms exist?

Claudiu T. Supuran

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Structure and function of carbonic anhydrases

Claudiu T. Supuran

BIOCHEMICAL JOURNAL (2016)

Article Oncology

Inhibition of carbonic anhydrase potentiates bevacizumab treatment in cholangiocarcinoma

Kulthida Vaeteewoottacharn et al.

TUMOR BIOLOGY (2016)

Review Pharmacology & Pharmacy

The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade

Rishil J. Kathawala et al.

DRUG RESISTANCE UPDATES (2015)

Article Nanoscience & Nanotechnology

Insights in the chemical components of liposomes responsible for P-glycoprotein inhibition

Joanna Kopecka et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2014)

Review Chemistry, Medicinal

Anticancer carbonic anhydrase inhibitors: a patent review (2008-2013)

Simona Maria Monti et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2013)

Review Oncology

Cancer drug resistance: an evolving paradigm

Caitriona Holohan et al.

NATURE REVIEWS CANCER (2013)

Review Biochemistry & Molecular Biology

Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds

A. Palmeira et al.

CURRENT MEDICINAL CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

ABC Proteins Protect the Human Body and Maintain Optimal Health

Kazumitsu Ueda

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

P-glycoprotein Inhibition: The Past, the Present and the Future

Richard A.J. Darby et al.

CURRENT DRUG METABOLISM (2011)

Article Chemistry, Medicinal

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

Alfonso Maresca et al.

JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Chemistry, Multidisciplinary

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors

Alfonso Maresca et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Chemistry, Analytical

High-Resolution Mass Spectrometers

Alan G. Marshall et al.

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

P-glycoprotein kinetics measured in plasma membrane vesicles and living cells

Paeivi Aeaenismaa et al.

BIOCHEMISTRY (2007)

Article Chemistry, Multidisciplinary

Saccharin inhibits carbonic anhydrases: Possible explanation for its unpleasant metallic aftertaste

Karen Koehler et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)

Review Oncology

Molecular mechanisms of drug resistance

DB Longley et al.

JOURNAL OF PATHOLOGY (2005)

Review Oncology

Multidrug resistance in cancer: Role of ATP-dependent transporters

MM Gottesman et al.

NATURE REVIEWS CANCER (2002)