Related references
Note: Only part of the references are listed.Repurposing antidepressants for anticancer drug discovery
Yihui Song et al.
DRUG DISCOVERY TODAY (2022)
Annual review of lysine-specific demethylase 1 (LSD1/KDM1A) inhibitors in 2021
Yihui Song et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles
Yasuko Koda et al.
ACS MEDICINAL CHEMISTRY LETTERS (2022)
Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism
Veronica Astro et al.
ISCIENCE (2022)
Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects
Yasushi Hattori et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2
Hideaki Niwa et al.
ACS MEDICINAL CHEMISTRY LETTERS (2022)
Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1
Xing-Jie Dai et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models
Rina Baba et al.
SCIENCE ADVANCES (2021)
Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity
Hiroki Kitagawa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication
Wen Juan Tu et al.
CELL DISCOVERY (2021)
Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models
Alessia Romussi et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
Jie Yang et al.
ACS OMEGA (2020)
Biological roles of LSD1 beyond its demethylase activity
Feiying Gu et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2020)
Development and Structural Evaluation of N-Alkylated trans-2-Phenylcyclopropylamine-Based LSD1 Inhibitors
Hideaki Niwa et al.
CHEMMEDCHEM (2020)
Bioinformatic Analysis of the Flavin-Dependent Amine Oxidase Superfamily: Adaptations for Substrate Specificity and Catalytic Diversity
Margarita A. Tararina et al.
JOURNAL OF MOLECULAR BIOLOGY (2020)
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate
Sang-Ah Kim et al.
MOLECULAR CELL (2020)
Tranylcypromine Based Lysine-Specific Demethylase 1 Inhibitor: Summary and Perspective
Xing-Jie Dai et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1)
Toufike Kanouni et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration
Amanda K. Engstrom et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex
Chiara Marabelli et al.
CELL REPORTS (2019)
Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer
Abel H. Y. Tan et al.
FRONTIERS IN IMMUNOLOGY (2019)
T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice
Satoru Matsuda et al.
NEUROPSYCHOPHARMACOLOGY (2019)
LSD1/KDM1A inhibitors in clinical trials: advances and prospects
Yuan Fang et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)
Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile
Hideaki Niwa et al.
MOLECULES (2018)
Epigenetic gene regulation by histone demethylases: emerging role in oncogenesis and inflammation
M. K. Kang et al.
ORAL DISEASES (2017)
Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases
Hideaki Niwa et al.
EPIGENETICS (2017)
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration
Luca Sartori et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship
Paola Vianello et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1
Yuichi Amano et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2017)
3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1
Fangrui Wu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide
Taeko Kakizawa et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
The growing structural and functional complexity of the LSD1/KDM1A histone demethylase
Chiara Marabelli et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2016)
LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors
Simona Pilotto et al.
HUMAN MOLECULAR GENETICS (2016)
Recent Progress in Histone Demethylase Inhibitors
Tom E. McAllister et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation
Eric Metzger et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
G-quadruplex RNA binding and recognition by the lysine-specific histone demethylase-1 enzyme
Alexander Hirschi et al.
RNA (2016)
TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy
Yi-Chao Zheng et al.
EPIGENOMICS (2016)
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation
Eric Metzger et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features
Valentina Speranzini et al.
SCIENCE ADVANCES (2016)
KDM1 Class Flavin-Dependent Protein Lysine Demethylases
Jonathan M. Burg et al.
BIOPOLYMERS (2015)
A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 inhibitors in SCLC
Helai P. Mohammad et al.
CANCER CELL (2015)
Lysine-Specific Demethylase 2 Suppresses Lipid Influx and Metabolism in Hepatic Cells
Katsuya Nagaoka et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
Histone Demethylase LSD2 Acts as an E3 Ubiquitin Ligase and Inhibits Cancer Cell Growth through Promoting Proteasomal Degradation of OGT
Yi Yang et al.
MOLECULAR CELL (2015)
Medicinal chemistry insights in the discovery of novel LSD1 inhibitors
Xueshun Wang et al.
EPIGENOMICS (2015)
A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1
Polina Prusevich et al.
ACS CHEMICAL BIOLOGY (2014)
Epigenetic reprogramming in breast cancer: From new targets to new therapies
Tiffany A. Katz et al.
ANNALS OF MEDICINE (2014)
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A
Paola Vianello et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Tranylcypromine Substituted cis-Hydroxycyclobutylnaphthamides as Potent and Selective Dopamine D3 Receptor Antagonists
Jianyong Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Differential Properties of Transcriptional Complexes Formed by the CoREST Family
Alvaro P. Barrios et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b
Qi Zhang et al.
CELL RESEARCH (2013)
Structural insight into substrate recognition by histone demethylase LSD2/KDM1b
Fei Chen et al.
CELL RESEARCH (2013)
Nonpeptidic Propargylamines as Inhibitors of Lysine Specific Demethylase 1 (LSD1) with Cellular Activity
Martin L. Schmitt et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
LSD2/KDM1B and Its Cofactor NPAC/GLYR1 Endow a Structural and Molecular Model for Regulation of H3K4 Demethylation
Rui Fang et al.
MOLECULAR CELL (2013)
Histone lysine demethylases as targets for anticancer therapy
Jonas W. Hojfeldt et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Expanding the Druggable Space of the LSD1/CoREST Epigenetic Target: New Potential Binding Regions for Drug-Like Molecules, Peptides, Protein Partners, and Chromatin
James C. Robertson et al.
PLOS COMPUTATIONAL BIOLOGY (2013)
Flavin-Dependent Enzymes in Cancer Prevention
Danuta Wojcieszynska et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Histone methylation: a dynamic mark in health, disease and inheritance
Eric L. Greer et al.
NATURE REVIEWS GENETICS (2012)
LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition
Riccardo Baron et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Regulation of somatic cell reprogramming through inducible mir-302 expression
Shi-Lung Lin et al.
NUCLEIC ACIDS RESEARCH (2011)
Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase LSD1-CoREST Complex
Riccardo Baron et al.
STRUCTURE (2011)
Structurally Designed trans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSDI/KDM1
Shinya Mimasu et al.
BIOCHEMISTRY (2010)
Potentiation of Ligand Binding through Cooperative Effects in Monoamine Oxidase B
Daniele Bonivento et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2
Claudia Binda et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Human LSD2/KDM1b/AOF1 Regulates Gene Transcription by Modulating Intragenic H3K4me2 Methylation
Rui Fang et al.
MOLECULAR CELL (2010)
A Feed-Forward Circuit Controlling Inducible NF-κB Target Gene Activation by Promoter Histone Demethylation
Dominic van Essen et al.
MOLECULAR CELL (2010)
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
Jinbo Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors
Ting-Yueh Tsai et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
A Novel Mammalian Flavin-dependent Histone Demethylase
Aristotele Karytinos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Discovery of a Highly Potent, Selective, and Bioavailable Soluble Epoxide Hydrolase Inhibitor with Excellent Ex Vivo Target Engagement
Hong C. Shen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints
David N. Ciccone et al.
NATURE (2009)
Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25 Å
Shinya Mimasu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
LSD1: oxidative chemistry for multifaceted functions in chromatin regulation
Federico Forneris et al.
TRENDS IN BIOCHEMICAL SCIENCES (2008)
Structural basis of LSD1-CoREST selectivity in histone H3 recognition
Federico Forneris et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine
Maojun Yang et al.
BIOCHEMISTRY (2007)
Structural basis of histone demethylation by LSD1 revealed by suicide inactivation
Maojun Yang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Crystal structure of human histone lysine-specific demethylase 1 (LSD1)
Yong Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase
Maojun Yang et al.
MOLECULAR CELL (2006)
Tranylcypromine - New perspectives on an old'' drug
Helge Frieling et al.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2006)
Crystal structure and mechanism of human lysine-specific demethylase-1
Pete Stavropoulos et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications
Min Gyu Lee et al.
CHEMISTRY & BIOLOGY (2006)
Epigenetic therapy of cancer: past, present and future
CB Yoo et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1
YJ Shi et al.
CELL (2004)
Share Paper
