4.8 Article

Biodegradable-Polymer-Blend-Based Surgical Sealant with Body-Temperature-Mediated Adhesion

Journal

ADVANCED MATERIALS
Volume 27, Issue 48, Pages 8056-8061

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201503691

Keywords

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Funding

  1. National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [R01EB019963, F31EB019289]
  2. Warren Citrin Graduate Fellowship
  3. Sheikh Zayed Institute for Pediatric Surgical Innovation

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The development of practical and efficient surgical sealants has the propensity to improve operational outcomes. A biodegradable polymer blend is fabricated as a nonwoven fiber mat in situ. After direct deposition onto the tissue of interest, the material transitions from a fiber mat to a film. This transition promotes polymer-substrate interfacial interactions leading to improved adhesion and surgical sealant performance.

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