Journal
JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS
Volume 61, Issue 10-11, Pages 1270-1281Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00222348.2022.2160133
Keywords
biological properties; blend scaffold; ethanediamine modified poly(lactide-co-glycolide); in-vitro degradation; poly(lactide-co-glycolide-co-epsilon-caprolactone)
Categories
Funding
- Scientific Research Fund of the Hunan Provincial Education Department [21A0323]
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A degradable blend scaffold composed of PLLGC and EMPLGA was prepared and characterized for its morphology and biocompatibility. The blend scaffold exhibited a porous structure and high cell proliferation.
A degradable blend scaffold composed of poly(D,L-lactide-co-glycolide-co-epsilon-caprolactone) (PLLGC) and ethanediamine modified poly(lactide-co-glycolide) (EMPLGA) was prepared by using a thermally induced phase separation technique. The morphologies of the PLLGC/EMPLGA blend scaffolds were characterized by using scanning electron microscopy (SEM). The in-vitro degradation behaviors and biocompatibility of the individual components and the blend were investigated by using rat L929 cells. The blend scaffolds showed a porous and well interconnected pore structure. The degradation rate sequence of the three scaffolds, the individual components and the blend, was EMPLGA > PLLGC/EMPLGA > PLLGC. The PLLGC/EMPLGA blend scaffold was non-cytotoxic and showed high cell proliferation.
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