Journal
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
Volume 64, Issue 12, Pages 2217-2239Publisher
WILEY
DOI: 10.1111/jipb.13423
Keywords
abiotic stress response; base excision repair; DNA demethylation; DNA methylation; histone modification; plant growth and development; plant microbe interaction
Categories
Funding
- Excellent Young Scientist Fund of NSFC
- Strategic Priority Research Program of CAS
- Shanghai Agriculture Applied Technology Development Program, China
- National Key R&D Program of China
- [31922008]
- [XDB27040108]
- [X20200101]
- [2021YFA1300401]
Ask authors/readers for more resources
Maintaining proper DNA methylation levels in the genome requires active demethylation of DNA. The discovery of the first eukaryotic DNA demethylase ROS1 in Arabidopsis thaliana has greatly expanded our understanding of the active DNA demethylation pathway and its regulation and biological functions in plants.
Maintaining proper DNA methylation levels in the genome requires active demethylation of DNA. However, removing the methyl group from a modified cytosine is chemically difficult and therefore, the underlying mechanism of demethylation had remained unclear for many years. The discovery of the first eukaryotic DNA demethylase, Arabidopsis thaliana REPRESSOR OF SILENCING 1 (ROS1), led to elucidation of the 5-methylcytosine base excision repair mechanism of active DNA demethylation. In the 20 years since ROS1 was discovered, our understanding of this active DNA demethylation pathway, as well as its regulation and biological functions in plants, has greatly expanded. These exciting developments have laid the groundwork for further dissecting the regulatory mechanisms of active DNA demethylation, with potential applications in epigenome editing to facilitate crop breeding and gene therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available