Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 237, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2022.112015
Keywords
Cu(II) complex; Dithiocarbazate; Crystal structure; DFT; Hirshfeld surface; Anticancer activity
Funding
- FAPDF
- CNPq
- FINEP/CTINFRA
- UnB
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES) [001]
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This work presents the synthesis and investigation of two dithiocarbazates and their Cu(II) complexes. The complexes show distorted square planar geometry and good agreement between calculated and experimental IR spectra. Hydrogen bonds and pi center dot center dot center dot pi stacking interactions were studied using Hirshfeld surface and fingerprint plots. In vitro studies revealed that the Cu(II) complexes displayed enhanced antitumor activity against human glioma cells compared to the free dithiocarbazates.
The present work reports the synthesis and investigation by semi-empirical Density Functional Theory (DFT), physical chemistry, and spectroscopic methods of two dithiocarbazates, 2-acetylpyridine-S-p-bromobenzyl-dithiocarbazate (HL1) and 2-acetylpyridine-S-p-nitrobenzyl-dithiocarbazate (HL2) and their Cu(II) complexes, [Cu(L-1)Cl] (1), [Cu(L-1)Br] (2), [Cu(L-2)Cl] (3) and [Cu(L-2)Br] (4). Single crystal X-ray analyzes showed distorted square planar geometry to the metal centers, which tridentate ligands coordinated by the NNS system and an additional halogen (Cl or Br) to complete the coordination sphere. Mass spectrometry data indicated the presence of [Cu(L-1)(DMF)](+) and [Cu(L-2)(DMF)](+), due to the exchanging of chloride/bromide ions and characteristic fragmentations of the compounds. The DFT composite method B97-3c was employed to optimize the geometries of ligands and complexes and IR spectra were calculated revealing good agreement with experimental data. Hydrogen bonds and pi center dot center dot center dot pi stacking interactions upon the molecular packing were investigated by Hirshfeld surface and fingerprint plots with the main interactions attributed to the H center dot center dot center dot H contacts. The biological activity of the dithiocarbazates and their Cu(II) complexes were evaluated in vitro against the human glioma U251 cells. Results revealed that the free dithiocarbazates present great in vitro antitumor activity that is increased after the complexation with copper. The measurement of cytotoxicity of the compounds showed biological activity in a low range of concentration, which indicates high efficiency as potential drugs.
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