Journal
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
Volume 33, Issue 2, Pages 611-624Publisher
SPRINGER
DOI: 10.1007/s10904-022-02529-0
Keywords
Polyoxometalates (POMs); Arsenic Polyoxotumgstate (KAW); Zeolitic Imidazolate Framework-8 (ZIF-8); Breast Cancer; Nano platforms (NPs)
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A pH-sensitive nanoplatform, PEGylated Zeolitic Imidazolate Framework-8 (ZIF-8/PEG), was used to modulate the cytotoxicity of arsenic polyoxotungstate (K6As2W18O62, KAW). The nanoplatforms showed high loading content and pH-responsive release of KAW. In vitro cytotoxicity experiments demonstrated that the designed nanoplatforms exhibited higher potency against breast cancer cells with lower side effects compared to free KAW.
A pH-sensitive nanoplatform of Pegylated Zeolitic Imidazolate Framework-8 (ZIF-8/PEG) was selected to modulate the cytotoxicity profile of arsenic polyoxotungstate (K6As2W18O62, KAW). The final nanoplatforms (NPs) showed a high loading content (31%) and a pH-responsive release of KAW. The in vitro cytotoxicity experiments showed that the IC50 decreased to about half in designed NPs on MDA-MB-231 cancer cells with a better level of cellular uptake (92%) than in control KAW (62%). Also, the final pegylated NPs were safer than free KAW on normal cells (85 mg/mL versus 45 mg/mL). The in vitro study confirmed the higher potency of the designed NPs against breast cancer cells with lower side effects than free KAW. [GRAPHICS] .
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