Serum uric acid/serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values

Article Cardiac & Cardiovascular Systems

Serum uric acid levels threshold for mortality in diabetic individuals: The URic acid Right for heArt Health (URRAH) project

Maria Masulli et al.

Summary: The SUA thresholds proposed by the URRAH study are also predictive of total and CV mortality in people with diabetes, with a threshold of 5.6 mg/dl being a candidate clinical cut-off for defining hyperuricemia in diabetic patients.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2022)

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Article Urology & Nephrology

The association between the serum uric acid to creatinine ratio and all-cause mortality in elderly hemodialysis patients

Zhihui Ding et al.

Summary: The serum uric acid to creatinine ratio is strongly associated with all-cause mortality in elderly hemodialysis patients and is more predictive than SUA or Scr alone.

BMC NEPHROLOGY (2022)

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Article Cardiac & Cardiovascular Systems

A higher ratio of serum uric acid to serum creatinine could predict the risk of total and cause specific mortality- insight from a US national survey

Mohsen Mazidi et al.

Summary: The study found that the ratio of serum uric acid to serum creatinine (SUA/SCr) is associated with mortality, with higher ratios increasing the risk of overall mortality and cardiovascular disease mortality, but showing a weaker association with cancer mortality.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Article Peripheral Vascular Disease

Serum uric acid, predicts heart failure in a large Italian cohort: search for a cut-off value the URic acid Right for heArt Health study

Maria L. Muiesan et al.

Summary: The study confirms that SUA is an independent risk factor for all heart failure and fatal heart failure, and shows that prognostic cut-off values can be identified for all heart failure (>5.34 mg/dL) and fatal heart failure (>4.89 mg/dL).

JOURNAL OF HYPERTENSION (2021)

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Article Cardiac & Cardiovascular Systems

Metabolic Factors Mediate the Association Between Serum Uric Acid to Serum Creatinine Ratio and Cardiovascular Disease

Anxin Wang et al.

Summary: The study found a positive association between SUA/SCr and CVD, and this association was partially mediated through blood lipids, BMI, blood pressure, hs-CRP, and blood glucose.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Endocrinology & Metabolism

Serum Uric acid is a better indicator of kidney impairment than serum uric acid to creatine ratio ; a cross sectional study of type 2 diabetes mellitus patients

Richard K. D. Ephraim et al.

Summary: This study found that serum uric acid is a better predictor of kidney impairment in T2DM patients compared to UA:CR. Participants in the fourth quartile of uric acid levels were significant indicators of kidney function, while a positive relationship was found between serum uric acid and CKD staging according to eGFR. Conversely, a negative relationship was found between UA:CR and CKD.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2021)

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Article Peripheral Vascular Disease