☆ 4.7 Review

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Related references

Note: Only part of the references are listed.

Article Engineering, Biomedical

Synergistic ferroptosis-gemcitabine chemotherapy of the gemcitabine loaded carbonaceous nanozymes to enhance the treatment and magnetic resonance imaging monitoring of pancreatic cancer

Gaorui Zhang et al.

Summary: This study developed carbonaceous nanoparticles loaded with gemcitabine as nanozymes and theranostic platform for MR-guided ferroptosis-chemo synergetic therapy of pancreatic adenocarcinoma. The nanoparticles effectively promoted ferroptosis therapy and achieved synergetic therapy with gemcitabine. The nanoparticles also had high magnetic susceptibility and were used for simultaneous MRI monitoring of the treatment.

ACTA BIOMATERIALIA (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Engineering Multienzyme-Mimicking Covalent Organic Frameworks as Pyroptosis Inducers for Boosting Antitumor Immunity

Liang Zhang et al.

Summary: A series of multienzyme-mimicking covalent organic frameworks (COFs) have been engineered to induce pyroptosis and remodel the tumor microenvironment, boosting cancer immunotherapy.

ADVANCED MATERIALS (2022)

Add to Collection

Article Oncology

Lobaplatin Induces Pyroptosis in Cervical Cancer Cells via the Caspase-3/GSDME Pathway

Jie Chen et al.

Summary: These findings demonstrate that GSDME-mediated pyroptosis is a new mechanism for lobaplatin to kill cervical cancer cells, suggesting that the caspase-3/GSDME pathway offers new insights into cancer chemotherapy.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2022)

Add to Collection

Review Oncology

Induction and application of ferroptosis in cancer therapy

Qing Nie et al.

Summary: This article summarizes the latest advances in ferroptosis-induced tumor therapy, including the characteristics and molecular mechanism of ferroptosis, its relationship with oxidative stress signaling pathways, and the application of ferroptosis inducers in systemic chemotherapy, radiotherapy, immunotherapy, and nanomedicine.

CANCER CELL INTERNATIONAL (2022)

Add to Collection

Article Hematology

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia

Rudy Birsen et al.

Summary: APR 246 is a promising therapeutic agent for myelodysplastic syndromes and acute myeloid leukemia that targets p53 mutated proteins. It has been found to reactivate the transcriptional activity of p53 mutants and induce p53-independent cell death. The study also demonstrates the association between APR 246 and ferroptosis, a recently described cell death process. The detoxification capacity of AML cells to maintain glutathione biosynthesis may play a key role in determining sensitivity to APR 246.

HAEMATOLOGICA (2022)

Add to Collection

Article Oncology

Atezolizumab and pembrolizumab in triple-negative breast cancer: a meta-analysis

Farah Latif et al.

Summary: Atezolizumab and pembrolizumab have shown positive efficacy outcomes and safety profiles in TNBC patients expressing PD-L1. Further research and exploration of biomarkers and endpoints are needed to optimize patient treatment protocols.

EXPERT REVIEW OF ANTICANCER THERAPY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The lncRNA BDNF-AS/WDR5/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination

Guoquan Huang et al.

Summary: This study found that BDNF-AS is highly expressed in gastric cancer and peritoneal metastasis tissues, and its overexpression is associated with gastric cancer progression and poor prognosis. BDNF-AS overexpression protects gastric cancer cells from ferroptosis and promotes the progression of gastric cancer and peritoneal metastasis. Mechanistically, BDNF-AS regulates the transcription of FBXW7 by recruiting WDR5, thus affecting the ubiquitination of VDAC3.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

Chen Zhang et al.

Summary: Ferroptosis, an iron-dependent form of cell death, plays a crucial role in tumor suppression and has the potential to reverse cancer therapy resistance.

MOLECULAR CANCER (2022)

Add to Collection

Article Oncology

Small-Molecule MMRi62 Induces Ferroptosis and Inhibits Metastasis in Pancreatic Cancer via Degradation of Ferritin Heavy Chain and Mutant p53

Junhui Li et al.

MOLECULAR CANCER THERAPEUTICS (2022)

Add to Collection

Article Cell Biology

Ferritinophagy-Mediated Ferroptosis and Activation of Keap1/Nrf2/HO-1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2'-Di-pyridineketone Hydrazone Dithiocarbamate Butyric Acid Ester

Deng Guan et al.

Summary: Research revealed that DpdtbA resisted TGF-beta 1-induced EMT through ferritinophagy-mediated ROS production, promoting EMT inhibition. Additionally, activation of Nrf2 played a role in regulating the cellular redox environment changes.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Add to Collection

Article Engineering, Biomedical

Fe(III)-Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis

Wenjie Feng et al.

Summary: A Fe(III)-Shikonin metal-polyphenol-coordinated supramolecular nanomedicine has been designed for combined therapy of tumors via ferroptosis and necroptosis, overcoming the drawbacks of Shikonin and showing potential for next-generation chemotherapeutic applications.

ADVANCED HEALTHCARE MATERIALS (2022)

Add to Collection

Article Oncology

Ophiopogonin B alleviates cisplatin resistance of lung cancer cells by inducing Caspase-1/GSDMD dependent pyroptosis

Ziyu Cheng et al.

Summary: Ophiopogonin B (OP-B) has been found to be effective against drug resistant lung cancer cells by inducing Caspase-1/GSDMD-dependent pyroptosis, thus alleviating cisplatin resistance in cells.

JOURNAL OF CANCER (2022)

Add to Collection

Article Immunology

Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell Carcinomas

Lijie Chen et al.

Summary: This study provides a comprehensive analysis of the interplay between autophagy and ferroptosis in SCCs, and their synergistic roles in manipulating the immunological TME.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Review Oncology

Ferroptosis in cancer and cancer immunotherapy

Lei Zhao et al.

Summary: Ferroptosis, a newly identified type of cell death dependent on lipid peroxidation, plays a vital role in cancer treatment as a potential strategy to overcome drug resistance in traditional therapies.

CANCER COMMUNICATIONS (2022)

Add to Collection

Article Oncology

Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma

Xiao Zhang et al.

Summary: This study found that plasma exosomes from LUAD patients can reduce lipid peroxidation and desensitize LUAD cells to ferroptosis. The exosomal circRNA_101093 (cir93) interacted with fatty acid-binding protein 3 (FABP3) to modulate the peroxidation reactions critical for ferroptosis. Blocking exosomes may be helpful for future LUAD treatment.

CANCER COMMUNICATIONS (2022)

Add to Collection

Article Oncology

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

Peng Liao et al.

Summary: T cell-derived interferon gamma (IFN γ) in combination with arachidonic acid (AA) induces immunogenic tumor ferroptosis, serving as a mechanism for CD8(+) T cell-mediated tumor killing. This process involves IFN γ stimulation of ACSL4 and alteration of tumor cell lipid pattern.

CANCER CELL (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Interplay between Cell Death and Cell Proliferation Reveals New Strategies for Cancer Therapy

Luke Loftus et al.

Summary: Cell division and cell death are essential processes in growth and development. Cancer is caused by abnormal regulation of these processes, and traditional anti-cancer treatments trigger apoptosis, to which cancer cells are resistant. Understanding how drugs kill cancer cells is crucial for developing more effective treatments. Cell cycle-independent forms of cell death, such as necroptosis or ferroptosis, have potential immunogenic effects, providing alternative strategies against tumors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Multidisciplinary Sciences

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis

Ting Zhang et al.

Summary: ADAR1 is a determinant of resistance to ICB therapy by repressing immunogenic dsRNA and Z-RNA. CBL0137 is a small molecule that activates ZBP1, reverses ICB unresponsiveness, and induced necroptosis.

NATURE (2022)

Add to Collection

Article Cell Biology

Apatinib Induces Ferroptosis of Glioma Cells through Modulation of the VEGFR2/Nrf2 Pathway

Liang Xia et al.

Summary: In this study, the researchers investigated a new mechanism of apatinib inhibiting the proliferation of glioma cells through the induction of ferroptosis. They found that apatinib could selectively induce ferroptosis in glioma cells, but not in normal astrocytes. This effect was mediated by the inhibition of the VEGFR2/Nrf2/Keap1 pathway. Overexpression of Nrf2 could reverse the induction of ferroptosis by apatinib.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Add to Collection

Article Multidisciplinary Sciences

Copper induces cell death by targeting lipoylated TCA cycle proteins

Peter Tsvetkov et al.

Summary: Copper is an essential cofactor for all organisms, but excessive copper can lead to cell death. We found that copper-dependent cell death mechanism is different from known mechanisms, and it is related to mitochondrial respiration. Copper directly binds to lipoylated components of the tricarboxylic acid cycle, causing protein aggregation and loss of iron-sulfur cluster proteins, ultimately leading to cell death.

SCIENCE (2022)

Add to Collection

Article Oncology

Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: Perspectives for immunotherapy of SCLC

Xing Niu et al.

Summary: Small cell lung cancer (SCLC) is an aggressive form of lung cancer with a poor prognosis. Although immune checkpoint inhibitors (ICIs) have been approved for the treatment of extensive-stage or relapsed SCLC, only a minority of patients respond to this therapy. The challenge for SCLC therapy is to transform the immune cold tumors into hot tumors that are more likely to respond to ICIs.

SEMINARS IN CANCER BIOLOGY (2022)

Add to Collection

Review Cell Biology

Interaction between macrophages and ferroptosis

Yan Yang et al.

Summary: Ferroptosis is a newly discovered iron-dependent cell death pathway characterized by lipid peroxidation and GSH depletion, participating in the development of various diseases. Macrophages, as immune cells, play crucial roles in regulating iron, lipid, and amino acid metabolisms, and recent studies target their polarization to induce ferroptosis in cancer cells for treatment.

CELL DEATH & DISEASE (2022)

Add to Collection

Article Respiratory System

Trichosanthin inhibits cell growth and metastasis by promoting pyroptosis in non-small cell lung cancer

Yan Tan et al.

Summary: This study found that trichosanthin (TCS) can inhibit the progression of non-small cell lung cancer (NSCLC) by promoting pyroptosis. These findings provide further information on the possible underlying mechanism of TCS in the treatment of NSCLC.

JOURNAL OF THORACIC DISEASE (2022)

Add to Collection

Article Immunology

Pyroptosis-Related Signature Predicts Prognosis and Immunotherapy Efficacy in Muscle-Invasive Bladder Cancer

Qi Zhang et al.

Summary: Pyroptosis plays a significant role in muscle invasive bladder cancer (MIBC) and offers new opportunities for its treatment.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Medicine, General & Internal

Integrated Analysis of Necroptosis-Related Genes for Prognosis, Immune Microenvironment Infiltration, and Drug Sensitivity in Colon Cancer

Rong He et al.

Summary: This study reveals the close relationship between necroptosis and prognosis and immune microenvironment in colon cancer. The NRS-score based on the 8-gene signature may be used to predict the sensitivity of immunotherapy and chemotherapy in colon cancer patients, and provides a foundation for future studies targeting necroptosis and its immune microenvironment.

FRONTIERS IN MEDICINE (2022)

Add to Collection

Article Pharmacology & Pharmacy

Comprehensive Analysis of Cuproptosis-Related Genes in Immune Infiltration and Prognosis in Melanoma

Haozhen Lv et al.

Summary: In this study, the correlation between cuproptosis-related genes and the prognosis of melanoma was explored by accessing and analyzing a public database. LIPT1 was identified as an important gene with prognostic value for melanoma patients. The study also revealed the correlation between LIPT1 expression and immune infiltration in melanoma, providing new clues for the prognostic assessment and immunotherapy of melanoma.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Article Immunology

Cuproptosis-Related Risk Score Predicts Prognosis and Characterizes the Tumor Microenvironment in Hepatocellular Carcinoma

Zhen Zhang et al.

Summary: The study finds that FDX1 is downregulated in hepatocellular carcinoma (HCC), and high expression of FDX1 is associated with longer survival time. HCC patients with high cuproptosis-related risk score (CRRS) have significantly lower overall survival (OS) and are enriched in cancer-related pathways. Mutation analyses reveal high mutational frequency of tumor suppressors such as P53 and BAP1, and low mutational frequency of CTNNB1 in high-CRRS HCC patients. Additionally, high CRRS is associated with increased pro-tumor immune infiltrates and high expression of immune checkpoints. Furthermore, CRRS has a high predictive value in determining the efficiency of sorafenib and non-responsiveness to TACE in HCC patients.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Genetics & Heredity

Pan-cancer analyses confirmed the cuproptosis-related gene FDX1 as an immunotherapy predictor and prognostic biomarker

Chi Zhang et al.

Summary: This study comprehensively explored the potential value of FDX1 as a prognostic and immunotherapeutic marker for pan-cancer. The results showed that FDX1 expression was significantly reduced in most cancer types and had prognostic value for the survival of certain cancer patients. Additionally, FDX1 was found to be correlated with clinical characteristics, tumor drug susceptibility or resistance, and immune-related pathways, immune cell infiltration, immune checkpoint genes, and immune regulatory genes.

FRONTIERS IN GENETICS (2022)

Add to Collection

Article Oncology

Arecoline Is Associated With Inhibition of Cuproptosis and Proliferation of Cancer-Associated Fibroblasts in Oral Squamous Cell Carcinoma: A Potential Mechanism for Tumor Metastasis

Jinfei Li et al.

Summary: This study found a close association between arecoline, cuproptosis, and CAFs, which might play an important role in the metastasis of OSCC.

FRONTIERS IN ONCOLOGY (2022)

Add to Collection

Article Medicine, Research & Experimental

Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non-small cell cancer

Wenjun Mao et al.

Summary: ICB therapy has achieved breakthroughs in treating advanced NSCLC, but the presence of immuno-cold tumors limits its efficacy. Targeting cholesterol synthesis can improve the treatment of immuno-cold tumors. Statin can inhibit the aggressiveness of lung cancer and enhance the response to ICB therapy.

JCI INSIGHT (2022)

Add to Collection

Article Cell Biology

ACSL4 is essential for radiation-induced intestinal injury by initiating ferroptosis

Qian Ji et al.

Summary: Lipid peroxidation-induced ferroptosis is a newly recognized type of programmed cell death. In this study, it was found that irradiation increased the expression of ferroptosis promotive genes and decreased the expression of ferroptosis suppressive genes in murine intestine tissues. Further experiments showed that ACSL4 is an important component for ferroptosis execution and its expression was upregulated in irradiated intestine tissues. Additionally, the ACSL4 inhibitor troglitazone was able to suppress lipid peroxidation and protect against tissue damage after irradiation.

CELL DEATH DISCOVERY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

An Enzyme-Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis-Based Synergistic Cancer Therapy

Yuzhi Xu et al.

Summary: Cuproptosis, a copper-dependent form of regulated cell death, offers great opportunities for cancer treatment. In this study, a glucose oxidase (GOx)-engineered nonporous copper(I) 1,2,4-triazolate ([Cu(tz)]) coordination polymer (CP) nanoplatform, denoted as GOx@[Cu(tz)], is developed for starvation-augmented cuproptosis and photodynamic synergistic therapy. In vivo experimental results show its effectiveness in inhibiting tumor growth.

ADVANCED MATERIALS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Cuproptosis identifies respiratory subtype of renal cancer that confers favorable prognosis

Kunping Li et al.

Summary: This study comprehensively investigates the characteristics of cuproptosis in clear-cell renal cell carcinoma (ccRCC) and finds that decreased cuproptosis is associated with better prognosis. It also reveals the relationship between cuproptosis and increased tricarboxylic acid cycle activity and decreased hypoxia signaling.

APOPTOSIS (2022)

Add to Collection

Article Biochemical Research Methods

High expression of cuproptosis-related SLC31A1 gene in relation to unfavorable outcome and deregulated immune cell infiltration in breast cancer: an analysis based on public databases

Linrong Li et al.

Summary: Cuproptosis-related genes play a significant role in the prognosis and biological significance of breast cancer, particularly the high expression level of SLC31A1 gene is associated with shorter overall survival, deregulated immune response, and metabolic pathways.

BMC BIOINFORMATICS (2022)

Add to Collection

Article Biology

Identification of cuproptosis-related subtypes, establishment of a prognostic model and tumor immune landscape in endometrial carcinoma

Jingsong Shan et al.

Summary: Cuproptosis, a mechanism of copper-dependent cell death, has the potential to be a new treatment for tumors resistant to conventional therapies. By analyzing changes in cuproptosis-related genes in endometrial cancer cohorts, three distinct gene clusters were identified, with patients in one cluster having higher survival probability and tumor microenvironment cell infiltration levels. A risk scoring system based on these genes can stratify patients into high-risk and low-risk groups, where low-risk patients have better prognosis and immunotherapy efficacy. Furthermore, the gene scores are correlated with other indicators such as copy number variation and tumor mutation load.

COMPUTERS IN BIOLOGY AND MEDICINE (2022)

Add to Collection

Review Oncology

The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy

Hua Wang et al.

Summary: This article discusses the importance of pyroptosis in the treatment of pediatric cancers, introducing the molecular mechanisms of pyroptosis and the challenges and opportunities in activating its pathways through various oncologic therapies.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro

Xiaolu Zhang et al.

Summary: Memo1 is a protein associated with cancer that binds copper ions and protects them from reactive oxygen species generation. It interacts with the cytoplasmic copper chaperone Atox1 and exchanges copper ions. This functionality may be a safety mechanism to cope with the increased demand of copper ions in cancer cells.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Add to Collection

Article Oncology

Cuproptosis-related lncRNA predict prognosis and immune response of lung adenocarcinoma

Fangwei Wang et al.

Summary: This study found that 16 cuproptosis-related lncRNAs can accurately predict the prognosis of patients with LUAD, providing new insights into clinical applications and immunotherapy.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

LINC00511/hsa-miR-573 axis-mediated high expression of Gasdermin C associates with dismal prognosis and tumor immune infiltration of breast cancer

Kai Sun et al.

Summary: This study investigated the role and mechanism of GSDMC in breast cancer. It found that elevated GSDMC expression was linked to a worse prognosis in breast invasive carcinoma. The study also identified the LINC00511/hsa-miR-573 axis as the most promising ncRNA-associated pathway for GSDMC in breast cancer. Additionally, significant correlations were demonstrated between GSDMC expression and immune infiltrates in breast cancer.

SCIENTIFIC REPORTS (2022)

Add to Collection

Article Immunology

Definition of a Novel Cuproptosis-Relevant lncRNA Signature for Uncovering Distinct Survival, Genomic Alterations, and Treatment Implications in Lung Adenocarcinoma

Zhuning Wang et al.

Summary: This study discovered a cuproptosis-relevant lncRNA signature that can efficiently predict clinical outcomes in lung adenocarcinoma (LUAD) patients. The high-risk subset displayed higher genomic alterations, immunological features, and stemness indexes, indicating potential benefits from immunotherapy. This research provides important information for personalized therapy in LUAD.

JOURNAL OF IMMUNOLOGY RESEARCH (2022)

Add to Collection

Article Immunology

Cuproptosis-related modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of kidney renal clear cell carcinoma

Zhiyong Cai et al.

Summary: Two distinct cuproptosis-related patterns were identified, with different impacts on prognosis and immune cell infiltration in kidney renal clear cell carcinoma (KIRC). The cuproptosis signature and risk score can guide precision therapy and accurate prognosis prediction for KIRC patients, exhibiting excellent prediction accuracy for survival outcomes.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Genetics & Heredity

Prognostic and immunological role of cuproptosis-related protein FDX1 in pan-cancer

Chen Xiao et al.

Summary: This study found that FDX1 gene is downregulated in various cancers, and its high expression is associated with better overall survival and death-specific survival. Additionally, FDX1 expression has a positive correlation with immune cell infiltration, tumor mutational burden, and microsatellite instability in certain cancer types. These findings suggest that FDX1 may serve as an interesting biomarker for cancer surveillance and future research.

FRONTIERS IN GENETICS (2022)

Add to Collection

Article Genetics & Heredity

Machine learning identification of cuproptosis and necroptosis-associated molecular subtypes to aid in prognosis assessment and immunotherapy response prediction in low-grade glioma

Ye Miao et al.

Summary: Both cuproptosis and necroptosis play important regulatory roles in LGG. We analyzed CNRGs to identify molecular subtypes and biomarkers associated with prognosis and immunotherapeutic response in LGG patients.

FRONTIERS IN GENETICS (2022)

Add to Collection

Article Cell Biology

Transcriptional and genetic alterations of cuproptosis-related genes correlated to malignancy and immune-infiltrate of esophageal carcinoma

Runmin Jiang et al.

Summary: This study systematically assessed the transcriptional and genetic alterations of cuproptosis-related genes (CRGs) in esophageal carcinoma (ESCA). A CRGs signature was identified and found to significantly stratify ESCA patients' survival. Higher CRGs scores were associated with worse overall survival, higher pathology grades, aberrant cell adhesion, and increased sensitivity to PI3K-AKT pathway inhibitors. Additionally, high CRGs were correlated with increased mutation load and abnormal APOBEC mutation. Interestingly, higher CRGs scores were anomalously associated with more immune infiltration, possibly explaining its malignancy through increased PD-L1 stability and a higher proportion of bystander T cells.

CELL DEATH DISCOVERY (2022)

Add to Collection

Review Cell Biology

Cell death affecting the progression of gastric cancer

Haoying Wang et al.

Summary: This review summarizes the effects of various cell death modalities on gastric cancer cells and the tumor microenvironment, as well as the molecular mechanisms and regulatory pathways involved. It explores the prevalence and complexity of cell death in gastric cancer progression and highlights the potential of cell death-related therapies in gastric cancer treatment.

CELL DEATH DISCOVERY (2022)

Add to Collection

Article Immunology

Cuproptosis-related gene FDX1 expression correlates with the prognosis and tumor immune microenvironment in clear cell renal cell carcinoma

Tao Wang et al.

Summary: This study found that decreased FDX1 gene expression in ccRCC patients is significantly associated with disease progression, unfavorable prognosis, and dysregulated immune cell infiltration.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Regulated cell death (RCD) in cancer: key pathways and targeted therapies

Fu Peng et al.

Summary: Regulated cell death (RCD), also known as programmed cell death (PCD), is a form of cell death that can be controlled by various biomacromolecules, distinct from accidental cell death (ACD). The different subroutines of RCD play crucial roles in tumorigenesis and may lead to the development of potential therapeutic strategies. Targeting the subroutines of RCD with small-molecule compounds has emerged as a promising therapeutic approach and has shown rapid progress in various types of human cancers.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

Weitong Gao et al.

Summary: Immunotherapy has made significant breakthroughs in cancer treatment, but the poor response of some tumors limits its application. Inducing non-apoptotic regulated cell death (RCD) may convert these unresponsive tumors into those that respond to immunotherapy. Autophagy, ferroptosis, pyroptosis, and necroptosis have been found to have both inhibitory and synergistic effects on antitumor immune responses, suggesting that targeted therapies against these processes combined with immunotherapy may be effective even in resistant tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Add to Collection

Review Oncology

The role of ROS in tumour development and progression

Eric C. Cheung et al.

Summary: Eukaryotic cells have complex systems to regulate reactive oxygen species (ROS), which are deregulated in cancer cells. ROS also modulate the tumor environment and affect stromal cells supporting metabolism, blood supply, and immune responses. The response to ROS is complex and depends on multiple factors, including ROS characteristics and tumor characteristics. Understanding the complexity of ROS in cancers is key to developing ROS-targeting therapies for cancer treatment.

NATURE REVIEWS CANCER (2022)

Add to Collection

Review Oncology

Connecting copper and cancer: from transition metal signalling to metalloplasia

Eva J. Ge et al.

Summary: Copper is a essential nutrient with both beneficial and toxic properties to cells. Recent progress in transition metal signaling has led to new connections between researchers from different disciplines, with potential for translating basic research into clinical therapies for diseases. The relationship between copper and cancer is particularly important, with opportunities for leveraging disease vulnerabilities through copper-dependent signaling pathways.

NATURE REVIEWS CANCER (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells

Kang Wang et al.

Summary: Ferroptosis, a form of iron-dependent cell death, has been implicated as a potential target for cancer therapy. The identification of BCAT2 as a regulator of ferroptosis suggests a novel therapeutic strategy for overcoming cancer resistance. Targeting BCAT2 may hold promise for enhancing the effectiveness of ferroptosis-inducing therapies in cancer treatment.

CELL DEATH AND DIFFERENTIATION (2021)

Add to Collection

Article Cell Biology

Identification of the pyroptosis-related prognostic gene signature and the associated regulation axis in lung adenocarcinoma

Wanli Lin et al.

Summary: A prognostic PRG signature containing five genes (NLRP7, NLRP1, NLRP2, NOD1, and CASP6) was identified for LUAD patients through comprehensive bioinformatics analysis. Additionally, a lncRNA KCNQ1OT1/miR-335-5p/NLRP1/NLRP7 regulatory axis was discovered, which may play a significant role in the progression of LUAD. Further research is needed to validate these findings.

CELL DEATH DISCOVERY (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

Lian-Hua Fu et al.

Summary: Chemodynamic therapy (CDT) is a promising method for killing cancer cells by converting intracellular hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals ((OH)-O-center dot). An intelligent nanocatalytic theranostics, PGC-DOX, was developed to address the limitations of endogenous H2O2 and high GSH levels in tumor cells, leading to efficient cancer therapy. The system combines H2O2 self-supply, GSH-elimination, and DOX-induced chemotherapy to effectively inhibit tumor growth with minimal side effects in vivo.

ADVANCED MATERIALS (2021)

Add to Collection

Article Oncology

Antitumor Effect of 5-Aminolevulinic Acid Through Ferroptosis in Esophageal Squamous Cell Carcinoma

Yuji Shishido et al.

Summary: 5-ALA induced ferroptosis through modulation of GPX4 and HMOX1 in esophageal squamous cell carcinoma (ESCC). Upregulation of GPX4 and downregulation of HMOX1 were found to be poor prognostic factors in ESCC. The antitumor effect of 5-ALA was seen both in vitro and in vivo, with an increase in lipid peroxidation and suppression of tumor growth.

ANNALS OF SURGICAL ONCOLOGY (2021)

Add to Collection

Article Oncology

Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

Yahui Ding et al.

Summary: This study identified a novel approach to treat TNBC by inducing ferroptosis through ubiquitination of GPX4 with the compound DMOCPTL, and revealed the role of GPX4 in regulating mitochondria-mediated apoptosis through up-regulation of EGR1 in TNBC cells. Furthermore, the prodrug Compound 13 showed promising anti-tumor effects in vivo with no apparent toxicity, suggesting its potential as a lead compound for developing effective anti-TNBC drugs.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Add to Collection

Article Pharmacology & Pharmacy

The mechanisms and therapeutic targets of ferroptosis in cancer

Long Ye et al.

Summary: Ferroptosis, a form of programmed cell death mediated by lipid peroxidation, plays a role in the regulation of antioxidant systems and shows potential efficacy in cancer, especially in combination with conventional or non-conventional therapies. New ferroptosis inducers with high selectivity and bioavailability are needed for more specific and potent targeting of tumor cells, and future clinical investigation of combining ferroptosis inducers with chemotherapy, radiotherapy, targeted therapy, and immunotherapy is warranted.

EXPERT OPINION ON THERAPEUTIC TARGETS (2021)

Add to Collection

Article Cell Biology

A Marine Terpenoid, Heteronemin, Induces Both the Apoptosis and Ferroptosis of Hepatocellular Carcinoma Cells and Involves the ROS and MAPK Pathways

Wen-Tsan Chang et al.

Summary: Heteronemin, a marine natural product, has shown inhibitory effects on hepatocellular carcinoma cells by inducing apoptosis through modulation of ROS, MAPK signaling pathways, and other mechanisms. These findings suggest that with structural modification, heteronemin could potentially serve as a potent therapeutic agent against HCC.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

p53 regulates lipid metabolism in cancer

Ling-Li Chen et al.

Summary: This review summarizes the function of p53 in lipid metabolism in cancer, highlighting its crucial role as a tumor suppressor gene. Further research on the role of p53 in lipid metabolism regulation may provide a potential therapeutic approach for cancer treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Add to Collection

Review Oncology

Modes of Regulated Cell Death in Cancer

Elle Koren et al.

Summary: Cell suicide pathways, known as regulated cell death (RCD), are crucial in organismal development, homeostasis, and pathogenesis. This review discusses key RCD modalities such as apoptosis, entosis, necroptosis, pyroptosis, and ferroptosis, and how they serve as a defense mechanism against cancer while also being exploited in oncogenesis. Therapeutic agents that activate RCD are outlined, along with novel strategies for tumor elimination, highlighting the critical importance of RCD in combating cancer.

CANCER DISCOVERY (2021)

Add to Collection

Article Cell Biology

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

Xingzhe Ma et al.

Summary: Understanding the mechanisms of how T cells become dysfunctional in a tumor microenvironment is crucial for cancer immunotherapy. This study found that CD36 expression in tumor-infiltrating CD8(+) T cells, induced by TME cholesterol, is associated with tumor progression and poor survival, and that genetic ablation of Cd36 in these T cells leads to enhanced tumor eradication. Targeting CD36 or inhibiting ferroptosis could restore T cell function and enhance antitumor efficacy, especially in combination with anti-PD-1 antibodies.

CELL METABOLISM (2021)

Add to Collection

Article Oncology

Apatinib induced ferroptosis by lipid peroxidation in gastric cancer

Liying Zhao et al.

Summary: In summary, apatinib induces lipid peroxidation through GPX4 mediated by SREBP-1a, leading to the ferroptosis of gastric cancer cells, including multi-drug resistant ones.

GASTRIC CANCER (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity

Junwei Hou et al.

Summary: ICP and CCP are processes of cell pyroptosis activated by different molecular mechanisms, affecting antitumor immunity and therapeutic outcomes.

MOLECULAR CELL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Regulation of lysyl oxidase expression in THP-1 cell-derived M2-like macrophages

Ryuhei Takemoto et al.

Summary: In M2-like macrophages, both HIF1α and STAT3 are essential for LOX induction, while the loss of FOXO1 facilitates HIF1α binding to the lox promoter region, promoting LOX induction.

JOURNAL OF CELLULAR BIOCHEMISTRY (2021)

Add to Collection

Article Immunology

Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis

Huabin Zhu et al.

Summary: MDSCs are immune suppressive cells that accumulate in pathological conditions to suppress T cell immune response. ASAH2 is highly expressed in tumor-infiltrating MDSCs and acts as a survival factor, targeting ASAH2 can induce MDSC ferroptosis to suppress MDSC accumulation in cancer immunotherapy.

JOURNAL OF IMMUNOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

Tumor-Associated Macrophages Promote Oxaliplatin Resistance via METTL3-Mediated m6A of TRAF5 and Necroptosis in Colorectal Cancer

Huanrong Lan et al.

Summary: The study found that infiltrated macrophage density in CRC tissues from OX-resistant patients was significantly higher, with increased m(6)A RNA content and METTL3 expression. M2-polarized TAMs enable OX resistance through elevated METTL3-mediated m(6)A modification in cells. Targeting M2-TAMs and METTL3-mediated m(6)A modification could be a promising adjuvant therapeutic strategy for CRC patients, especially for OX-resistant CRC patients.

MOLECULAR PHARMACEUTICS (2021)

Add to Collection

Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Add to Collection

Article Pharmacology & Pharmacy

Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer

Xumin Zhou et al.

Summary: Flubendazole has potential inhibitory effects on castration-resistant prostate cancer, exerting anti-cancer effects by hindering the cell cycle and activating ferroptosis, and showing synergistic effects with 5-fluorouracil in chemotherapy.

PHARMACOLOGICAL RESEARCH (2021)

Add to Collection

Article Cell Biology

Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells

Haein An et al.

Summary: Tetraarsenic hexoxide induces pyroptotic cell death in TNBC cells by activating mitochondrial ROS-mediated caspase-3/GSDME pathway, effectively suppressing tumor growth and metastasis.

CELL DEATH & DISEASE (2021)

Add to Collection

Article Multidisciplinary Sciences

Strategies to package recombinant Adeno-Associated Virus expressing the N-terminal gasdermin domain for tumor treatment

Yuan Lu et al.

Summary: Researchers have developed two strategies to package recombinant adeno-associated virus expressing GSDM(NT) efficiently into tumor cells, inducing pyroptosis and robust immune responses in preclinical cancer models.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Oncology

Apatinib Promotes Ferroptosis in Colorectal Cancer Cells by Targeting ELOVL6/ACSL4 Signaling

Xiangyang Tian et al.

Summary: The study demonstrated that apatinib promotes ferroptosis in CRC cells by targeting ELOVL6/ACSL4. This finding provides a new mechanism supporting the application of apatinib in the clinical treatment of CRC.

CANCER MANAGEMENT AND RESEARCH (2021)

Add to Collection

Article Cell Biology

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

Rajendra Karki et al.

Summary: The study uncovers the role of ADAR1 in suppressing ZBP1-mediated PANoptosis and promoting tumorigenesis. Additionally, the use of IFN-gamma and NEI KPT-330 regresses melanoma in a ZBP1-dependent manner, providing important insights for cancer therapeutic strategies.

CELL REPORTS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

GW4064 enhances the chemosensitivity of colorectal cancer to oxaliplatin by inducing pyroptosis

Jing Guo et al.

Summary: Long-term oxaliplatin therapy may lead to drug resistance and severe adverse events, limiting its clinical use. A combination of GW4064 and oxaliplatin showed synergistic effects in colon cancer cells, inhibiting cell growth and inducing cell death to slow tumor growth.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Add to Collection

Article Immunology

An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma

Xinwen Wang et al.

Summary: By identifying ICD-associated subtypes, a new classification system based on ICD signatures can be established in HNSCC patients, which helps in assessing prognosis and effectiveness of immunotherapy.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Oncology

Immunogenic ferroptosis and where to find it?

Robin Demuynck et al.

Summary: Ferroptosis is a newly discovered form of regulated cell death distinct from apoptosis and necroptosis, and has potential in anticancer therapy. However, ferroptotic cancer cells may pose a risk of tumor evasion due to decreased phagocytosis and antigen cross-presentation. Factors such as lactate, acidification, and hypoxia in the tumor microenvironment play a role in promoting ferroptosis resistance and affecting its immunogenicity.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Add to Collection

Article Oncology

Necroptosis-Related lncRNAs: Predicting Prognosis and the Distinction between the Cold and Hot Tumors in Gastric Cancer

Zirui Zhao et al.

Summary: This study constructed a model with necroptosis-related lncRNAs to predict prognosis and aid in precision medication for gastric cancer patients. Analysis of IC50 differences between risk groups and clustering helped effectively distinguish between cold and hot tumors, contributing to precise mediation.

JOURNAL OF ONCOLOGY (2021)

Add to Collection

Review Oncology

Pyroptosis: a new paradigm of cell death for fighting against cancer

Yixin Tan et al.

Summary: Pyroptosis is an inflammatory form of cell death with tumor suppressive function and the ability to evoke anti-tumor immune responses. Cancer therapies induce pyroptosis, enhancing anti-tumor immunity, but also leading to side effects on normal cells.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Add to Collection

Article Oncology

Cross-talk of pyroptosis and tumor immune landscape in lung adenocarcinoma

Xin Wang et al.

Summary: In this study, three distinct pyroptosis patterns were identified in LUAD patients based on the expression profiles of 48 PRGs, showing the crosstalk between pyroptosis and the tumor immune landscape. The Pyro score was established as an independent prognostic factor and immunotherapy predictor for LUAD, providing a new way towards personalized immunotherapeutic strategies.

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

Add to Collection

Article Materials Science, Biomaterials

Exosomes secreted by macrophages upon copper ion stimulation can promote angiogenesis

Zhong Wang et al.

Summary: The study investigated the effects of copper ions on macrophage-derived exosome secretion, uptake behavior by endothelial cells, and angiogenic-induction ability. The results showed that copper ions had little impact on exosome secretion, but the exosomes could enhance the angiogenic ability of endothelial cells.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Add to Collection

Review Pharmacology & Pharmacy

Tumor microenvironment as a therapeutic target in cancer

Yi Xiao et al.

Summary: This article summarizes the current progress in targeting the tumor microenvironment in both drug development and clinical trials, emphasizing the challenges in intervening in the tumor microenvironment and discussing strategies to maximize therapeutic benefits. New technologies and approaches to better understand the tumor microenvironment are explored in this context.

PHARMACOLOGY & THERAPEUTICS (2021)

Add to Collection

Article Plant Sciences

Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells

Jingjing Du et al.

Summary: Shuganning injection (SGNI), a traditional Chinese patent medicine, selectively inhibits the proliferation of TNBC cells through induction of ferroptosis dependent on heme oxygenase 1 (HO-1). HO-1 promotes intracellular labile iron pool accumulation, leading to ferroptotic cell death of TNBC cells.

PHYTOMEDICINE (2021)

Add to Collection

Article Oncology

Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines

Annkathrin Koch et al.

Summary: Burkitt's lymphoma (BL) is a highly aggressive form of B-cell non-Hodgkin's lymphoma. While clinical outcomes in children have improved in recent years, the prognosis for adults remains poor. Research has shown that combination treatment with Smac mimetic BV6 and TRAIL can induce necroptosis in BL, highlighting the potential for novel treatment strategies. These findings demonstrate the critical role of MLKL in necroptotic signaling and suggest that MLKL may serve as a prognostic marker for the success of necroptosis-based therapies in BL.

NEOPLASIA (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence

Geraldine Luis et al.

Summary: The study revealed that SCD1 and FABP4 play essential roles in tumor recurrence by enhancing antioxidant and anti-ferroptotic resources. Inhibiting lipid transport and targeting SCD1 can effectively reduce tumor regrowth.

REDOX BIOLOGY (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Identification of ferroptosis genes in immune infiltration and prognosis in thyroid papillary carcinoma using network analysis

Ruoting Lin et al.

Summary: The study analyzed ferroptosis-related genes in papillary thyroid carcinoma and established a new model to predict patient prognosis, identifying crucial genes associated with ferroptosis and immune cells in PTC.

BMC GENOMICS (2021)

Add to Collection

Article Oncology

Necrosulfonamide reverses pyroptosis-induced inhibition of proliferation and differentiation of osteoblasts through the NLRP3/caspase-1/GSDMD pathway

Jingliao Zhang et al.

Summary: The study demonstrated that the pyroptosis inhibitor necrosulfonamide (NSA) promotes the proliferation and differentiation of osteoblasts by inhibiting the NLRP3/caspase-1/GSDMD pyroptosis pathway. This suggests the potential application of NSA in improving osteoblast function in fracture repair and highlights the value of the NLRP3/caspase-1/GSDMD pyroptosis pathway as a pharmaceutical target.

EXPERIMENTAL CELL RESEARCH (2021)

Add to Collection

Article Oncology

Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

Jing Cai et al.

Summary: The study reveals that triptolide eliminates head and neck cancer cells through inducing GSDME-mediated pyroptosis, and this effect is achieved by inhibiting HK-II and promoting caspase 3 activation. Combination with the SLC7A11 inhibitor erastin shows a strong synergistic effect in suppressing tumor survival in vitro and in a nude mice model. This research provides new insights into the use of TPL in cancer therapy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Add to Collection

Article Biochemistry & Molecular Biology

RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment

Han-Hee Park et al.

Summary: The study identifies TRIM28 as a co-repressor regulating transcriptional activity during necroptosis. Activated RIPK3 phosphorylates TRIM28, inhibiting its chromatin binding activity and contributing to increased cytokine expression and immunoregulatory processes. RIPK3 activation-dependent derepression of TRIM28 in cancer cells leads to enhanced immunostimulatory cytokine production and robust anti-tumor immunity.

MOLECULAR CANCER (2021)

Add to Collection

Article Oncology

Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A

Wei Gao et al.

Summary: Elesclomol inhibits colorectal cancer by inducing copper overload, promoting oxidative stress, and regulating ferroptosis through targeting ATP7A.

MOLECULAR ONCOLOGY (2021)

Add to Collection

Review Gastroenterology & Hepatology

Cell death in pancreatic cancer: from pathogenesis to therapy

Xin Chen et al.

Summary: Pancreatic cancer is a devastating gastrointestinal cancer with late diagnosis, limited treatment success and poor prognosis, primarily composed of pancreatic ductal adenocarcinoma (PDAC). The occurrence and progression of PDAC are influenced by various factors, and the exact impact of cell death on PDAC is not yet well described.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Add to Collection

Editorial Material Cell Biology

Identifying and targeting the Achilles heel of a recalcitrant cancer

Triparna Sen

Summary: Targeting replication stress response proteins in small cell lung cancer can activate the innate immune cGAS-STING pathway, leading to enhanced antitumor response of immunotherapy.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Ferroptosis in the tumor microenvironment: perspectives for immunotherapy

Huanji Xu et al.

Summary: Targeting ferroptosis as a new approach for anticancer therapy shows potential as it induces lipid peroxidation in cancer cells. Understanding how immune cells in the tumor microenvironment respond to lethal lipid peroxides may uncover new possibilities for cancer immunotherapy. This study provides an overview of the metabolic processes involved in ferroptosis and explores its roles in cancer immunity, highlighting the potential for targeted therapy.

TRENDS IN MOLECULAR MEDICINE (2021)

Add to Collection

Article Cell Biology

DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism

Jing Du et al.

Summary: The combination of dihydroartemisinin (DHA) and cisplatin (DDP) synergistically enhances the cytotoxicity of pancreatic ductal adenocarcinoma (PDAC) cells by inducing ferroptosis. The impairment of mitochondrial homeostasis and the accumulation of free iron and lipid peroxidation contribute to the cytotoxic effects. Pharmacological manipulation of iron levels can modulate the sensitivity of PDAC cells to DHA/DDP-induced ferroptosis. These findings suggest a promising therapeutic strategy for PDAC treatment.

CELL DEATH & DISEASE (2021)

Add to Collection

Article Multidisciplinary Sciences

Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer

Wen Liu et al.

Summary: High cholesterol levels have been associated with increased risk of cancer, with cholesterol metabolite 27HC potentially leading to the generation of cancer cells resistant to ferroptosis, thereby promoting tumor growth and metastasis. These findings emphasize the significance of ferroptosis in tumor development and suggest that dyslipidemia/hypercholesterolemia impacts cancer pathogenesis by selecting for cells resistant to ferroptotic cell death.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Immunology

Construction of a Ferroptosis-Related Nine-lncRNA Signature for Predicting Prognosis and Immune Response in Hepatocellular Carcinoma

Zhijie Xu et al.

Summary: This study investigated the association between differentially expressed lncRNAs and ferroptosis-related genes in HCC, identifying a nine-lncRNA-based prognostic model. The model could be a promising personalized tool for prognosis and immune response prediction in HCC patients.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Oncology

The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis

Paris Jabeen Asif et al.

Summary: Metastasis in cancer is closely associated with cancer-associated fibroblasts (CAFs), which play a key role in cancer progression by contributing to extracellular matrix deposition and remodeling, extensive crosstalk with cancer cells, epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and therapy resistance. Understanding the role of CAFs in the process of metastasis, particularly in colorectal cancer (CRC) with high stromal infiltration, is crucial for developing targeted therapeutics and advancing research in this field.

CANCERS (2021)

Add to Collection

Article Oncology

Ferroptosis-Related Gene Signature Promotes Ovarian Cancer by Influencing Immune Infiltration and Invasion

Yang You et al.

Summary: A scoring system based on ferroptosis-related genes was constructed to predict the prognosis of ovarian cancer patients, indicating that ferroptosis may affect ovarian cancer progression by mediating tumor metastasis and immune landscape. Additionally, novel drugs targeting ovarian cancer were predicted based on the scores.

JOURNAL OF ONCOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment

Chih-Hsiung Hsieh et al.

Summary: This study demonstrates the dual properties of zero-valent-iron nanoparticles (ZVI-NP) in inducing cancer-specific cytotoxicity and anti-cancer immunity, highlighting their potential as an advanced integrated anti-cancer strategy. ZVI-NP not only induces cancer cell death but also enhances the anti-tumor immune response in animal models.

THERANOSTICS (2021)

Add to Collection

Review Medicine, Research & Experimental

Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment

Sheng-Kai Hsu et al.

Summary: New types of programmed cell death, such as ferroptosis, necroptosis, and pyroptosis, have emerged in recent years, playing significant roles in cancer progression modulation and being closely related to immune regulation in the tumor microenvironment. Pyroptosis, in particular, has been identified as crucial for host defense and bridging innate and adaptive immunity, showing benefits for cancer immunotherapies.

THERANOSTICS (2021)

Add to Collection

Article Medicine, Research & Experimental

Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy

Jianbing Du et al.

Summary: This study successfully designed an exosome-based platform to deliver ferroptosis inducer and photosensitizer into liver cancer cells, inducing cell death significantly while minimizing toxicity to the liver and kidney.

THERANOSTICS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway

Haiqing He et al.

Summary: The study demonstrated that GSDMB promotes bladder cancer progression and interacts with STAT3 to activate signaling pathways in tumor cells. Moreover, USP24 stabilizes GSDMB to activate STAT3 signaling in bladder cancer cells.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Add to Collection

Review Medicine, Research & Experimental

Turning cold tumors into hot tumors by improving T-cell infiltration

Yuan-Tong Liu et al.

Summary: Immunotherapy, particularly through immune checkpoint inhibitors, has significantly improved the treatment of malignant tumors by enhancing T cell infiltration into tumors. Understanding the mechanisms underlying cold tumors, which lack T cell infiltration, is crucial to improving immunotherapy efficacy. Strategies to transform cold tumors into hot tumors and increase T cell infiltration are discussed, along with the potential of nanomedicines in enhancing tumor immunotherapy.

THERANOSTICS (2021)

Add to Collection

Review Oncology

Gasdermin E-mediated programmed cell death: An unpaved path to tumor suppression

Yueyuan Wang et al.

Summary: GSDME, an effector of secondary necrosis, has been identified as a tumor suppressor in cancer tissues. It interacts with multiple pathways of cell death, including apoptosis and autophagy, demonstrating potential anti-cancer activity.

JOURNAL OF CANCER (2021)

Add to Collection

Article Oncology

Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway

Jiabin Zhou et al.

INVESTIGATIONAL NEW DRUGS (2020)

Add to Collection

Review Oncology

Ferroptosis is a type of autophagy-dependent cell death

Borong Zhou et al.

SEMINARS IN CANCER BIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

Ling F. Ye et al.

ACS CHEMICAL BIOLOGY (2020)

Add to Collection

Article Pharmacology & Pharmacy

Induction of an MLKL mediated non-canonical necroptosis through reactive oxygen species by tanshinol A in lung cancer cells

Xin Liu et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Add to Collection

Review Medicine, Research & Experimental

Pyroptosis: A new frontier in cancer

Yuan Fang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence

Chao-Chieh Lin et al.

CELL DEATH AND DIFFERENTIATION (2020)

Add to Collection

Article Cell Biology

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

Guang Lei et al.

CELL RESEARCH (2020)

Add to Collection

Article Oncology

Epigenetic Regulation of RIP3 Suppresses Necroptosis and Increases Resistance to Chemotherapy in NonSmall Cell Lung Cancer

Qiong Wang et al.

TRANSLATIONAL ONCOLOGY (2020)

Add to Collection

Article Oncology

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

Dan A. Erkes et al.

CANCER DISCOVERY (2020)

Add to Collection

Article Oncology

Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-kappa B/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer

Jin-Feng Teng et al.

CANCERS (2020)

Add to Collection

Review Cell Biology

The Immuno-Modulatory Effects of Inhibitor of Apoptosis Protein Antagonists in Cancer Immunotherapy

Jessica Michie et al.

CELLS (2020)

Add to Collection

Article Immunology

Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

Yuying Liu et al.

SCIENCE IMMUNOLOGY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Metal-Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH

Evelyn Ploetz et al.

ADVANCED MATERIALS (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Self-Boosting Catalytic Nanoreactors Integrated with Triggerable Crosslinking Membrane Networks for Initiation of Immunogenic Cell Death by Pyroptosis

Junjie Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition

Renxin Yi et al.

BIOSCIENCE REPORTS (2020)

Add to Collection

Article Cell Biology

Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis

Zhaodi Zheng et al.

CELL CYCLE (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Mechanism and regulation of pyroptosis-mediated in cancer cell death

Jianwei Ruan et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

Add to Collection

Article Oncology

RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis

Lei Wu et al.

CANCER IMMUNOLOGY RESEARCH (2020)

Add to Collection

Article Immunology

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

Robin Schwarzer et al.

IMMUNITY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Mitochondria Targeting as an Effective Strategy for Cancer Therapy

Poorva Ghosh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Nanostructured toxins for the selective destruction of drug-resistant human CXCR4+ colorectal cancer stem cells

Naroa Serna et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection

Article Multidisciplinary Sciences

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Zhiwei Zhou et al.

SCIENCE (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Pharmacological Inhibition of Necroptosis Promotes Human Breast Cancer Cell Proliferation and Metastasis

Feng Shen et al.

ONCOTARGETS AND THERAPY (2020)

Add to Collection

Article Cell Biology

Inhibition of BRD4 prevents proliferation and epithelial-mesenchymal transition in renal cell carcinoma via NLRP3 inflammasome-induced pyroptosis

Yi-Fan Tan et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Article Multidisciplinary Sciences

Irradiated tumor cell-derived microparticles mediate tumor eradication via cell killing and immune reprogramming

Chao Wan et al.

SCIENCE ADVANCES (2020)

Add to Collection

Correction Multidisciplinary Sciences

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation (vol 10, pg 852, 2020)

Huipeng Jiao et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Metabolites released from apoptotic cells act as tissue messengers

Christopher B. Medina et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Zhibin Zhang et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

A bioorthogonal system reveals antitumour immune function of pyroptosis

Qinyang Wang et al.

NATURE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

John K. Eaton et al.

NATURE CHEMICAL BIOLOGY (2020)

Add to Collection

Article Immunology

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

Jun Jacob Hu et al.

NATURE IMMUNOLOGY (2020)

Add to Collection

Review Oncology

Targeting apoptosis in cancer therapy

Benedito A. Carneiro et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Add to Collection

Review Immunology

The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

Min Zheng et al.

IMMUNOLOGICAL REVIEWS (2020)

Add to Collection

Review Pharmacology & Pharmacy

The progress and perspective of nanoparticle-enabled tumor metastasis treatment

Wei Zhang et al.

ACTA PHARMACEUTICA SINICA B (2020)

Add to Collection

Review Pharmacology & Pharmacy

The role of lysosome in regulated necrosis

Aqu Alu et al.

ACTA PHARMACEUTICA SINICA B (2020)

Add to Collection

Article Pharmacology & Pharmacy

Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

Xiaowei Zhang et al.

ACTA PHARMACEUTICA SINICA B (2020)

Add to Collection

Review Cell Biology

Necroptosis in Immuno-Oncology and Cancer Immunotherapy

Jenny Sprooten et al.

CELLS (2020)

Add to Collection

Article Medicine, Research & Experimental

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

Tomonori Tadokoro et al.

JCI INSIGHT (2020)

Add to Collection

Review Oncology

Mitochondrial metabolism and cancer metastasis

Dandan Yu et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

Add to Collection

Review Oncology

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Add to Collection

Article Engineering, Biomedical

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

Pengfei Zhao et al.

BIOMATERIALS (2020)

Add to Collection

Article Oncology

Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma

Jana Lippmann et al.

TRANSLATIONAL ONCOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

Leo Aubert et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Medicine, Research & Experimental

Pyroptosis is involved in the inhibitory effect of FL118 on growth and metastasis in colorectal cancer

Zhenxue Tang et al.

LIFE SCIENCES (2020)

Add to Collection

Article Multidisciplinary Sciences

Lymph protects metastasizing melanoma cells from ferroptosis

Jessalyn M. Ubellacker et al.

NATURE (2020)

Add to Collection

Article Cell Biology

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

Junwei Hou et al.

NATURE CELL BIOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Succination inactivates gasdermin D and blocks pyroptosis

Fiachra Humphries et al.

SCIENCE (2020)

Add to Collection

Article Medicine, Research & Experimental

Anti-cancer effect of engineered recombinant interleukin 18

Jirakrit Saetang et al.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2020)

Add to Collection

Article Biology

Synergistic effect of TEMPO-coated TiO2 nanorods for PDT applications in MCF-7 cell line model

M. Fakhar-e-Alam et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2020)

Add to Collection

Article Oncology

LPS Enhances the Chemosensitivity of Oxaliplatin in HT29 Cells via GSDMD-Mediated Pyroptosis

Li-Sha Wu et al.

CANCER MANAGEMENT AND RESEARCH (2020)

Add to Collection

Article Oncology

Abnormal Ferroptosis in Myelodysplastic Syndrome

Qi Lv et al.

FRONTIERS IN ONCOLOGY (2020)

Add to Collection

Review Oncology

Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers

Minlin Jiang et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Necroptosis in Intestinal Inflammation and Cancer: New Concepts and Therapeutic Perspectives

Anna Negroni et al.

BIOMOLECULES (2020)

Add to Collection

Article Multidisciplinary Sciences

A metastasis map of human cancer cell lines

Xin Jin et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer

Ji-Yoon Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection

Article Multidisciplinary Sciences

Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway

Enyong Dai et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Review Pharmacology & Pharmacy

Eicosanoids in Cancer: New Roles in Immunoregulation

Amber M. Johnson et al.

FRONTIERS IN PHARMACOLOGY (2020)

Add to Collection

Review Immunology

Tumor-Associated Macrophages in Tumor Immunity

Yueyun Pan et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Review Oncology

The Multifaceted Roles of Copper in Cancer: A Trace Metal Element with Dysregulated Metabolism, but Also a Target or a Bullet for Therapy

Pierre Lelievre et al.

CANCERS (2020)

Add to Collection

Correction Cell Biology

IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer (vol 2020, 1675613, 2020)

Lei Zhang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Add to Collection

Article Oncology

Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity

Iuliia Efimova et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Add to Collection

Article Biology

De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors

Samuel T. Workenhe et al.

COMMUNICATIONS BIOLOGY (2020)

Add to Collection

Article Oncology

HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway

Gao Tan et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

Patricia P. Yee et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Oncology

Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice

Lien Van Hoecke et al.

ONCOIMMUNOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis

Peng Chen et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection

Article Medicine, Research & Experimental

Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis

Jaewang Lee et al.

THERANOSTICS (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Mitochondria-targeted delivery and light controlled release of iron prodrug and CO to enhance cancer therapy by ferroptosis

Fan Gao et al.

NEW JOURNAL OF CHEMISTRY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular principles of metastasis: a hallmark of cancer revisited

Jawad Fares et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection

Review Cell Biology

Necrotic, apoptotic and autophagic cell fates triggered by nanoparticles

Reza Mohammadinejad et al.

AUTOPHAGY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

The development of the concept of ferroptosis

Tal Hirschhorn et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Add to Collection

Article Plant Sciences

Anthocyanin is involved in the activation of pyroptosis in oral squamous cell carcinoma

Yue Er et al.

PHYTOMEDICINE (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

Cheng-cheng Zhang et al.

APOPTOSIS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly

Kaiwen W. Chen et al.

EMBO JOURNAL (2019)

Add to Collection

Article Biochemistry & Molecular Biology

DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin

Jing Du et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Targeting Tumor Microenvironment for Cancer Therapy

Catarina Roma-Rodrigues et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Article Multidisciplinary Sciences

Ferroptosis as a target for protection against cardiomyopathy

Xuexian Fang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Add to Collection

Article Cell Biology

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

Junhui Yu et al.

CELL DEATH & DISEASE (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer

Fan Zhang et al.

ACS NANO (2019)

Add to Collection

Review Oncology

Targeting Ferroptosis to Iron Out Cancer

Behrouz Hassannia et al.

CANCER CELL (2019)

Add to Collection

Article Oncology

Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis

Lu Wang et al.

CANCER LETTERS (2019)

Add to Collection

Article Oncology

Shikonin derivatives for cancer prevention and therapy

Joelle C. Boulos et al.

CANCER LETTERS (2019)

Add to Collection

Article Oncology

Intracellular Delivery of an Antibody Targeting Gasdermin-B Reduces HER2 Breast Cancer Aggressiveness

Angela Molina-Crespo et al.

CLINICAL CANCER RESEARCH (2019)

Add to Collection

Article Gastroenterology & Hepatology

Sorafenib Induces Pyroptosis in Macrophages and Triggers Natural Killer Cell-Mediated Cytotoxicity Against Hepatocellular Carcinoma

Carina Hage et al.

HEPATOLOGY (2019)

Add to Collection

Article Immunology

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization

Zhonghua Liu et al.

IMMUNITY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Complex roles of necroptosis in cancer

Fang Zhu et al.

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2019)

Add to Collection

Article Biochemistry & Molecular Biology

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

J. L. Hu et al.

MOLECULAR CANCER (2019)

Add to Collection

Review Biochemistry & Molecular Biology

The role of necroptosis in cancer biology and therapy

Yitao Gong et al.

MOLECULAR CANCER (2019)

Add to Collection

Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Mitochondrial metabolism promotes adaptation to proteotoxic stress

Peter Tsvetkov et al.

NATURE CHEMICAL BIOLOGY (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Shikonin-induced necroptosis in nasopharyngeal carcinoma cells via ROS overproduction and upregulation of RIPKI/RIPK3/MLKL expression

Tiancong Liu et al.

ONCOTARGETS AND THERAPY (2019)

Add to Collection

Article Multidisciplinary Sciences

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

Corey Rogers et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Article Multidisciplinary Sciences

Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells

William R. Taylor et al.

SCIENTIFIC REPORTS (2019)

Add to Collection

Article Oncology

Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study

Caroline Robert et al.

LANCET ONCOLOGY (2019)

Add to Collection

Article Cell Biology

Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis

Jue Hou et al.

CELL DEATH & DISEASE (2019)

Add to Collection

Article Cell Biology

Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment

Adelie Dumont et al.

CELL DEATH & DISEASE (2019)

Add to Collection

Article Multidisciplinary Sciences

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

Yilong Zou et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Article Immunology

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity

Annelise G. Snyder et al.

SCIENCE IMMUNOLOGY (2019)

Add to Collection

Article Pharmacology & Pharmacy

Polyphyllin VI, a saponin from Trillium tschonoskii Maxim: induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer

Jin-Feng Teng et al.

PHARMACOLOGICAL RESEARCH (2019)

Add to Collection

Review Cell Biology

The role of pyroptosis in cancer: pro-cancer or pro-host?

Xiaojing Xia et al.

CELL DEATH & DISEASE (2019)

Add to Collection

Article Oncology

Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11

Xueting Lang et al.

CANCER DISCOVERY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Systems Biology of Cancer Metastasis

Yasir Suhail et al.

CELL SYSTEMS (2019)

Add to Collection

Article Oncology

The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma

Yang Kong et al.

FRONTIERS IN ONCOLOGY (2019)

Add to Collection

Review Oncology

Induction of Pyroptosis and Its Implications in Cancer Management

Yan-Yang Wang et al.

FRONTIERS IN ONCOLOGY (2019)

Add to Collection

Article Oncology

Targeted exosome-encapsulated erastin induced ferroptosis in triple negative breast cancer cells

Mengyu Yu et al.

CANCER SCIENCE (2019)

Add to Collection

Editorial Material Microbiology

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

Jason W. Upton et al.

CELL HOST & MICROBE (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

Jin-Xuan Fan et al.

NANO LETTERS (2019)

Add to Collection

Article Multidisciplinary Sciences

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll et al.

NATURE (2019)

Add to Collection

Article Multidisciplinary Sciences

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker et al.

NATURE (2019)

Add to Collection

Review Immunology

ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)

R. K. Subbarao Malireddi et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch

Liping Chen et al.

APOPTOSIS (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Schwannoma gene therapy by adeno-associated virus delivery of the pore-forming protein Gasdermin-D

Sherif G. Ahmed et al.

CANCER GENE THERAPY (2019)

Add to Collection

Article Cell Biology

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

Caitlin W. Brown et al.

DEVELOPMENTAL CELL (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro

Pian Yu et al.

ACTA PHARMACOLOGICA SINICA (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Tumor microenvironment responsive FePt/MoS2 nanocomposites with chemotherapy and photothermal therapy for enhancing cancer immunotherapy

Dongsheng Zhang et al.

NANOSCALE (2019)

Add to Collection

Review Oncology

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

Jose Pedro Friedmann Angeli et al.

NATURE REVIEWS CANCER (2019)

Add to Collection

Article Medicine, Research & Experimental

RIP3 promotes colitis-associated colorectal cancer by controlling tumor cell proliferation and CXCL1-induced immune suppression

Zhen-Yu Liu et al.

THERANOSTICS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment

Jian Hu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model

Yan Zhang et al.

CELL CHEMICAL BIOLOGY (2019)

Add to Collection

Article Cell Biology

GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity

Qin Chen et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2019)

Add to Collection

Article Oncology

Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2(+ve) breast cancer metastasis

Aadya Nagpal et al.

BREAST CANCER RESEARCH (2019)

Add to Collection

Article Oncology

Bufalin inhibits human breast cancer tumorigenesis by inducing cell death through the ROS-mediated RIP1/RIP3/PARP-1 pathways

Yanlan Li et al.

CARCINOGENESIS (2018)

Add to Collection

Article Cell Biology

Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

Xianmin Mu et al.

CELL CYCLE (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis

Fengjiao Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Add to Collection

Article Medicine, Research & Experimental

Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis

Qinrui Han et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

Michael M. Gaschler et al.

NATURE CHEMICAL BIOLOGY (2018)

Add to Collection

Review Cell Biology

ROS signalling in the biology of cancer

Jennifer N. Moloney et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)

Add to Collection

Editorial Material Cell Biology

Fighting Resilient Cancers with Iron

Jonathan J. Chen et al.

TRENDS IN CELL BIOLOGY (2018)

Add to Collection

Article Multidisciplinary Sciences

Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer

Jutaek Nam et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Multidisciplinary Sciences

Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells

Nathalia Pizato et al.

SCIENTIFIC REPORTS (2018)

Add to Collection

Article Oncology

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

Jipeng Guo et al.

CANCER RESEARCH AND TREATMENT (2018)

Add to Collection

Article Oncology

Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers

David L. Elion et al.

CANCER RESEARCH (2018)

Add to Collection

Article Chemistry, Medicinal

Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway

Gaofei Wei et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4

Xin Jin et al.

MOLECULAR CELL (2018)

Add to Collection

Article Multidisciplinary Sciences

Cryo-EM structure of the gasdermin A3 membrane pore

Jianbin Ruan et al.

NATURE (2018)

Add to Collection

Article Cell Biology

Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation

Tengfei Huang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

Add to Collection

Article Multidisciplinary Sciences

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death

Pontus Orning et al.

SCIENCE (2018)

Add to Collection

Article Cell & Tissue Engineering

Pyroptosis of MCF7 Cells Induced by the Secreted Factors of hUCMSCs

Yang Jiao et al.

STEM CELLS INTERNATIONAL (2018)

Add to Collection

Article Pharmacology & Pharmacy

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

Xinbing Sui et al.

FRONTIERS IN PHARMACOLOGY (2018)

Add to Collection

Article Cell Biology

Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance

Sheng-Yen Lin et al.

AUTOPHAGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients

Abdulkerim Kasim Baltaci et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2017)

Add to Collection

Review Cell Biology

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

Haitao Yu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate

Anna L. Greenshields et al.

MOLECULAR CARCINOGENESIS (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

Marian C. Okondo et al.

NATURE CHEMICAL BIOLOGY (2017)

Add to Collection

Review Immunology

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

Si Ming Man et al.

IMMUNOLOGICAL REVIEWS (2017)

Add to Collection

Review Biochemistry & Molecular Biology

A Critical Review on the Effect of Docosahexaenoic Acid (DHA) on Cancer Cell Cycle Progression

Marnie Newell et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Add to Collection

Article Immunology

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D

Kimberley D. Gutierrez et al.

JOURNAL OF IMMUNOLOGY (2017)

Add to Collection

Article Chemistry, Medicinal

Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome

Yan Ren et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Add to Collection

Article Chemistry, Medicinal

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Add to Collection

Editorial Material Multidisciplinary Sciences

METASTASIS Lymphatic detours for cancer

Ayuko Hoshino et al.

NATURE (2017)

Add to Collection

Article Multidisciplinary Sciences

Integrative clinical genomics of metastatic cancer

Dan R. Robinson et al.

NATURE (2017)

Add to Collection

Letter Multidisciplinary Sciences

Upholding a role for EMT in breast cancer metastasis

Xin Ye et al.

NATURE (2017)

Add to Collection

Article Multidisciplinary Sciences

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang et al.

NATURE (2017)

Add to Collection

Article Multidisciplinary Sciences

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Vasanthi S. Viswanathan et al.

NATURE (2017)

Add to Collection

Review Immunology

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

Robin A. Aglietti et al.

TRENDS IN IMMUNOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

Corey Rogers et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Article Biotechnology & Applied Microbiology

Biogenic selenium nanoparticles induce ROS-mediated necroptosis in PC-3 cancer cells through TNF activation

Praveen Sonkusre et al.

JOURNAL OF NANOBIOTECHNOLOGY (2017)

Add to Collection

Article Oncology

Pro-necrotic molecules impact local immunosurveillance in human breast cancer

Gautier Stoll et al.

ONCOIMMUNOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

Jong-Lyel Roh et al.

REDOX BIOLOGY (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

CELL (2017)

Add to Collection

Article Mathematical & Computational Biology

A systematic analysis of FDA-approved anticancer drugs

Jingchun Sun et al.

BMC SYSTEMS BIOLOGY (2017)

Add to Collection

Review Oncology

Microenvironmental regulation of tumour angiogenesis

Michele de Palma et al.

NATURE REVIEWS CANCER (2017)

Add to Collection

Article Engineering, Biomedical

Killing colon cancer cells through PCD pathways by a novel hyaluronic acid-modified shell-core nanoparticle loaded with RIP3 in combination with chloroquine

Xueyan Hou et al.

BIOMATERIALS (2017)

Add to Collection

Article Cell Biology

Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

Add to Collection

Article Oncology

RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells

Ulrike Hoeckendorf et al.

CANCER CELL (2016)

Add to Collection

Article Oncology

Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma

Kevin D. McCormick et al.

CARCINOGENESIS (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Regulated cell death and adaptive stress responses

Lorenzo Galluzzi et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Add to Collection

Review Biochemical Research Methods

Impact of the physical microenvironment on tumor progression and metastasis

Fabian Spill et al.

CURRENT OPINION IN BIOTECHNOLOGY (2016)

Add to Collection

Article Multidisciplinary Sciences

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

Lena Seifert et al.

NATURE (2016)

Add to Collection

Article Multidisciplinary Sciences

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu et al.

NATURE (2016)

Add to Collection

Article Multidisciplinary Sciences

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Cristovao M. Sousa et al.

NATURE (2016)

Add to Collection

Article Multidisciplinary Sciences

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

Boris Strilic et al.

NATURE (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Kenichi Shimada et al.

NATURE CHEMICAL BIOLOGY (2016)

Add to Collection

Article Cell Biology

Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

S. Ma et al.

CELL DEATH & DISEASE (2016)

Add to Collection

Article Oncology

Key roles of necroptotic factors in promoting tumor growth

Xinjian Liu et al.

ONCOTARGET (2016)

Add to Collection

Article Oncology

Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma

Qun Chu et al.

ONCOTARGET (2016)

Add to Collection

Article Oncology

Serum Concentrations of Selenium and Copper in Patients Diagnosed with Pancreatic Cancer

Marcin R. Lener et al.

CANCER RESEARCH AND TREATMENT (2016)

Add to Collection

Article Cell Biology

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

Tania Love Aaes et al.

CELL REPORTS (2016)

Add to Collection

Review Oncology

Targeting metastasis

Patricia S. Steeg

NATURE REVIEWS CANCER (2016)

Add to Collection

Article Immunology

ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways

Teneema Kuriakose et al.

SCIENCE IMMUNOLOGY (2016)

Add to Collection

Article Engineering, Biomedical

Graphene oxide as a chemosensitizer: Diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects

Guan-Yu Chen et al.

BIOMATERIALS (2015)

Add to Collection

Article Oncology

Statin Use and Survival from Lung Cancer: A Population-Based Cohort Study

Chris R. Cardwell et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2015)

Add to Collection

Article Oncology

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

Christophe Louandre et al.

CANCER LETTERS (2015)

Add to Collection

Article Cell Biology

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

Gi-Bang Koo et al.

CELL RESEARCH (2015)

Add to Collection

Article Multidisciplinary Sciences

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki et al.

NATURE (2015)

Add to Collection

Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

Add to Collection

Article Multidisciplinary Sciences

Ferroptosis as a p53-mediated activity during tumour suppression

Le Jiang et al.

NATURE (2015)

Add to Collection

Article Cell Biology

Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death

K. Moriwaki et al.

CELL DEATH & DISEASE (2015)

Add to Collection

Article Multidisciplinary Sciences

Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death

Dobrin Draganov et al.

SCIENTIFIC REPORTS (2015)

Add to Collection

Review Biotechnology & Applied Microbiology

Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies

Agnieszka Zimna et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Add to Collection

Article Oncology

Receptor-interacting protein kinase 3 is a predictor of survival and plays a tumor suppressive role in colorectal cancer

X. Feng et al.

NEOPLASMA (2015)

Add to Collection

Review Biotechnology & Applied Microbiology

From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment

Claudia Cerella et al.

BIOTECHNOLOGY ADVANCES (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

CELL (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells

V. Derangere et al.

CELL DEATH AND DIFFERENTIATION (2014)

Add to Collection

Review Dermatology

Resistance to RAF Inhibitors Revisited

Edward Hartsough et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

Add to Collection

Article Multidisciplinary Sciences

Inflammatory caspases are innate immune receptors for intracellular LPS

Jianjin Shi et al.

NATURE (2014)

Add to Collection

Article Multidisciplinary Sciences

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Joseph D. Mancias et al.

NATURE (2014)

Add to Collection

Article Multidisciplinary Sciences

Gasdermin-B Promotes Invasion and Metastasis in Breast Cancer Cells

Marta Hergueta-Redondo et al.

PLOS ONE (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis

Gwen MacDonald et al.

SCIENCE SIGNALING (2014)

Add to Collection

Article Biology

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Scott J. Dixon et al.

ELIFE (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Serum levels of ferritin, copper, and zinc in patients with oral cancer

Hamed Mortazavi et al.

Biomedical Journal (2014)

Add to Collection

Article Oncology

Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma

Lauren E. Colbert et al.

CANCER (2013)

Add to Collection

Article Oncology

RIP1 potentiates BPDE-induced transformation in human bronchial epithelial cells through catalase-mediated suppression of excessive reactive oxygen species

Qiong Wang et al.

CARCINOGENESIS (2013)

Add to Collection

Article Medicine, Research & Experimental

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

Sahar A. Saddoughi et al.

EMBO MOLECULAR MEDICINE (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

William J. Kaiser et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Add to Collection

Review Biotechnology & Applied Microbiology

Modulation of oxidative stress as an anticancer strategy

Chiara Gorrini et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Add to Collection

Article Multidisciplinary Sciences

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

Nobuhiko Kayagaki et al.

SCIENCE (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

Liming Sun et al.

CELL (2012)

Add to Collection

Article Biochemistry & Molecular Biology

The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells

Masazumi Nagai et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Add to Collection

Article Multidisciplinary Sciences

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

Jie Zhao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection

Article Oncology

Combined effects of serum trace metals and polymorphisms of CYP1A1 or GSTM1 on non-small cell lung cancer: A hospital based case-control study in China

Yongtang Jin et al.

CANCER EPIDEMIOLOGY (2011)

Add to Collection

Review Biochemistry & Molecular Biology

Programmed Cell Death in Animal Development and Disease

Yaron Fuchs et al.

CELL (2011)

Add to Collection

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

Add to Collection

Article Multidisciplinary Sciences

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Gina M. De Nicola et al.

NATURE (2011)

Add to Collection

Article Multidisciplinary Sciences

Non-canonical inflammasome activation targets caspase-11

Nobuhiko Kayagaki et al.

NATURE (2011)

Add to Collection

Review Cell Biology

Molecular mechanisms of necroptosis: an ordered cellular explosion

Peter Vandenabeele et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Add to Collection

Review Genetics & Heredity

Genetic Control of Programmed Cell Death During Animal Development

Barbara Conradt

ANNUAL REVIEW OF GENETICS (2009)

Add to Collection

Article Pharmacology & Pharmacy

Copper Regulation of Hypoxia-Inducible Factor-1 Activity

Wenke Feng et al.

MOLECULAR PHARMACOLOGY (2009)

Add to Collection

Article Oncology

Cell Proliferation, Cell Cycle Abnormalities, and Cancer Outcome in Patients with Barrett's Esophagus: A Long-term Prospective Study

Dennis L. Chao et al.

CLINICAL CANCER RESEARCH (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Identification of RIP1 kinase as a specific cellular target of necrostatins

Alexei Degterev et al.

NATURE CHEMICAL BIOLOGY (2008)

Add to Collection

Article Surgery

G2/M cell-cycle arrest and apoptosis by n-3 fatty acids in a pancreatic cancer model

Thomas Dekoj et al.

JOURNAL OF SURGICAL RESEARCH (2007)

Add to Collection

Article Biochemistry & Molecular Biology

Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia

X. L. Zuo et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

A Degterev et al.

NATURE CHEMICAL BIOLOGY (2005)

Add to Collection

© Peeref 2019-2024. All rights reserved.