Glioma is associated with exposure to legacy and alternative per- and polyfluoroalkyl substances

Data on the occurrences of legacy and alternative per-and polyfluoroalkyl substances (PFASs) in glioma are scarce. It remains unclear if PFASs exposure is related to the prevalence of glioma. A total of 137 glioma and 40 non-glioma brain tissue samples from patients recruited from the Nanfang Hospital, South China were analyzed for 17 PFAS compounds. Perfluorohexanoic acid, perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (FOSA), and 6:2 chlorinated polyfluorinated ether sulfonate were frequently detected (> 60 %) in glioma. The total concentrations (range; median) of 17 PFASs in glioma (0.20-140; 3.1 ng g(-1)) were slightly higher than those in non-glioma (0.35-32; 2.2 ng g(-1)), but without sta-tistical significance. The PFAS concentrations in males were statistically higher (p < 0.05) than those in females. Elevated glioma grades were associated with higher concentrations of PFOA, PFOS, and FOSA. Positive corre-lations were observed between PFAS concentrations (especially for PFOA) and Ki-67 or P53 expression,

Automated summary

This study examines the occurrence and concentrations of various PFASs in glioma, finding that PFASs were frequently detected in glioma samples. Higher concentrations of certain PFASs were associated with elevated glioma grades, and males had higher PFAS concentrations.