4.7 Article

Lack of evolutionary convergence in multiple primary lung cancer suggests insufficient specificity of personalized therapy

Related references

Note: Only part of the references are listed.
Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Biochemistry & Molecular Biology

Intratumoral heterogeneity in cancer progression and response to immunotherapy

Ilio Vitale et al.

Summary: Tumors evolve under various pressures and exhibit considerable heterogeneity in genetic, phenotypic, and behavioral aspects. This intratumoral heterogeneity influences disease progression and treatment sensitivity, necessitating consideration of multiple levels of heterogeneity in future therapeutic approaches.

NATURE MEDICINE (2021)

Review Biochemistry & Molecular Biology

Lung stem cells in regeneration and tumorigenesis

Yuting Chen et al.

Summary: The adult lung is a mostly quiescent organ with low cell turnover rate, but can undergo repair and regeneration in response to injuries. Lung regeneration relies on proliferation of regionally distributed pulmonary stem cells, with genetic lineage tracing and single-cell transcriptomic techniques revealing essential molecular signaling pathways involved. Dysregulation of these pathways can lead to lung cancer development, where different subtypes share common cells of origin and may exhibit drug resistance due to pathological transitions.

JOURNAL OF GENETICS AND GENOMICS (2021)

Article Biochemistry & Molecular Biology

OncoVar: an integrated database and analysis platform for oncogenic driver variants in cancers

Tao Wang et al.

Summary: OncoVar is a platform that can prioritize the oncogenic ability of somatic mutations and cancer genes by reanalyzing data from different cancer types. It identifies driver mutations, driver genes, and pathogenic pathways, providing visualizations to help researchers understand the relationships between cancer and driver mutations. Identification of actionable driver alterations can lead to promising druggable targets and repurposing opportunities for combinational therapies.

NUCLEIC ACIDS RESEARCH (2021)

Review Oncology

A compendium of mutational cancer driver genes

Francisco Martinez-Jimenez et al.

NATURE REVIEWS CANCER (2020)

Article Multidisciplinary Sciences

Neoantigen-directed immune escape in lung cancer evolution

Rachel Rosenthal et al.

NATURE (2019)

Review Respiratory System

Multiple primary lung cancer: a rising challenge

Chen Chen et al.

JOURNAL OF THORACIC DISEASE (2019)

Article Genetics & Heredity

Quantitative evidence for early metastatic seeding in colorectal cancer

Zheng Hu et al.

NATURE GENETICS (2019)

Article Multidisciplinary Sciences

Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

Xin Hu et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

COSMIC: the Catalogue Of Somatic Mutations In Cancer

John G. Tate et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemistry & Molecular Biology

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

Sudhir Kumar et al.

MOLECULAR BIOLOGY AND EVOLUTION (2018)

Article Multidisciplinary Sciences

Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors

Anna S. Trigos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer

Pengfei Ma et al.

NATURE COMMUNICATIONS (2017)

Editorial Material Cardiac & Cardiovascular Systems

Novel Strategy for Synchronous Multiple Primary Lung Cancer Displaying Unique Molecular Profiles

Chenyang Ye et al.

ANNALS OF THORACIC SURGERY (2016)

Review Genetics & Heredity

The Ecology and Evolution of Cancer: The Ultra-Microevolutionary Process

Chung-I Wu et al.

ANNUAL REVIEW OF GENETICS, VOL 50 (2016)

Article Genetics & Heredity

Identification of neutral tumor evolution across cancer types

Marc J. Williams et al.

NATURE GENETICS (2016)

Article Genetics & Heredity

Clonal evolution of glioblastoma under therapy

Jiguang Wang et al.

NATURE GENETICS (2016)

Article Multidisciplinary Sciences

Genomic heterogeneity of multiple synchronous lung cancer

Yu Liu et al.

NATURE COMMUNICATIONS (2016)

Article Biotechnology & Applied Microbiology

The Ensembl Variant Effect Predictor

William McLaren et al.

GENOME BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M

Kenneth S. Thress et al.

NATURE MEDICINE (2015)

Article Multidisciplinary Sciences

Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution

Shaoping Ling et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

Article Multidisciplinary Sciences

Comprehensive molecular profiling of lung adenocarcinoma

Eric A. Collisson et al.

NATURE (2014)

Article Multidisciplinary Sciences

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

Andriy Marusyk et al.

NATURE (2014)

Review Multidisciplinary Sciences

Clonal evolution in cancer

Mel Greaves et al.

NATURE (2012)

Article Biotechnology & Applied Microbiology

Absolute quantification of somatic DNA alterations in human cancer

Scott L. Carter et al.

NATURE BIOTECHNOLOGY (2012)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Editorial Material Biochemistry & Molecular Biology

Modernizing Reference Genome Assemblies

Deanna M. Church et al.

PLOS BIOLOGY (2011)

Article Biochemistry & Molecular Biology

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

Aaron McKenna et al.

GENOME RESEARCH (2010)

Article Biochemical Research Methods

Fast and accurate short read alignment with Burrows-Wheeler transform

Heng Li et al.

BIOINFORMATICS (2009)

Review Genetics & Heredity

The evolution of genetic networks by non-adaptive processes

Michael Lynch

NATURE REVIEWS GENETICS (2007)