Journal
JOURNAL OF FOOD PROTECTION
Volume 86, Issue 3, Pages -Publisher
INT ASSOC FOOD PROTECTION
DOI: 10.1016/j.jfp.2023.100053
Keywords
Animal host; Colonization; EAEC; EHEC; Reservoir
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Escherichia coli O104:H4, a hybrid serotype carrying virulence factors from enteroaggregative (EAEC) and Shiga toxin-producing (STEC) pathotypes, is identified as a foodborne pathogen and the cause of a multicountry outbreak in 2011. Although it is not commonly found in animals or related environments, the strain has been shown to colonize the intestines of experimental animals, suggesting potential evolutionary changes that could facilitate the colonization of new reservoirs.
Escherichia coli O104:H4, a hybrid serotype carrying virulence factors from enteroaggregative (EAEC) and Shiga toxin-producing (STEC) pathotypes, is the reported cause of a multicountry outbreak in 2011. Evaluation of potential routes of human contamination revealed that this strain is a foodborne pathogen. In contrast to STEC strains, whose main reservoir is cattle, serotype O104:H4 has not been commonly isolated from animals or related environments, suggesting an inability to naturally colonize the gut in hosts other than humans. However, contrary to this view, this strain has been shown to colonize the intestines of experimental animals in infectious studies. In this minireview, we provide a systematic summary of reports highlighting potential evolutionary changes that could facilitate the colonization of new reservoirs by these bacteria.
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