4.3 Article

One-pot synthesis of difluoromethyl-containing 1,2,3,4-tetrahydropyridines

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

An Overview of the Biological Evaluation of Selected Nitrogen-Containing Heterocycle Medicinal Chemistry Compounds

Oluwakemi Ebenezer et al.

Summary: Heterocyclic compounds are natural compounds with favorable properties and significant pharmaceutical importance. They have diverse applications as smart biomimetics and possess active pharmacophores in complex structures, making them indispensable in drug discovery. Among different heterocyclic ring systems, nitrogen heterocyclic compounds are more abundant in nature and have considerable pharmacological significance. This review highlights pioneering studies in the biological assessment of nitrogen-containing compounds, such as triazoles, tetrazoles, imidazole/benzimidazoles, pyrimidines, and quinolines. It covers publications from April 2020 to February 2022 and will be beneficial for researchers in medicinal chemistry and pharmacology.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Chemistry, Inorganic & Nuclear

Concise Synthesis of Trifluoromethylated Spiro [indoline-3,4′-pyrazolo [3,4-b]pyridine] Derivatives via One-pot MCRs

Zeyu Li et al.

Summary: A series of poly-heterocycles containing hemi-aminal moieties were efficiently synthesized using different reactions, and their structures were confirmed by various methods.

JOURNAL OF FLUORINE CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Biological Properties and Applications of Betalains

Izabela Sadowska-Bartosz et al.

Summary: Betalains are water-soluble pigments found in plants and mushrooms, with different types such as betacyanins and betaxanthins. Betacyanins, with betanin as a common example, are commonly used in the food industry. Betalains not only possess antioxidant properties, but also have wide applications in the food industry and other fields.

MOLECULES (2021)

Article Chemistry, Medicinal

2,2,2-trifluoro-1-(1,4,5,6-tetrahydropyridin-3-yl)ethanone derivative as efflux pump inhibitor in Mycobacterium tuberculosis

Priscila Cristina Bartolomeu Halicki et al.

Summary: NUNL02 has the potential to increase the susceptibility of multidrug resistant Mycobacterium tuberculosis strains to anti-TB drugs, possibly by affecting the efflux mechanism and killing the bacillus under nutrient deprivation. This compound shows promise as a new adjuvant for TB treatment.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

Article Chemistry, Organic

Synthesis via the Mannich Reaction and Biological Activity of Novel Fluorinated Camptothecin Derivatives

Chuanhao Wang et al.

Summary: The hexacyclic fluorinated camptothecin derivatives showed higher activity, among which (9S,10S)-2-cyclopropyl-9-ethyl-10-fluoro-9-hydroxy-2,3,9,10,12,15-hexahydro-1H,13H-[1,3]oxazino[5,6-f]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-13-one exhibited potent antitumor activity against A549 and T24 cell lines with effective topoisomerase I inhibitory activity.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS (2021)

Review Biochemistry & Molecular Biology

Synthesis of Biologically Active Molecules through Multicomponent Reactions

Daniel Insuasty et al.

MOLECULES (2020)

Review Chemistry, Multidisciplinary

Organofluorine chemistry: promising growth areas and challenges

Larisa Politanskaya et al.

RUSSIAN CHEMICAL REVIEWS (2019)

Article Chemistry, Inorganic & Nuclear

Recent progress in the strategic incorporation of fluorine into medicinally active compounds

Krupanandan Haranahalli et al.

JOURNAL OF FLUORINE CHEMISTRY (2019)

Article Chemistry, Inorganic & Nuclear

Synthesis and cytotoxic activities of difluoroacetyl-substituted hexahydropyrimidine derivatives

Natalya N. Gibadullina et al.

JOURNAL OF FLUORINE CHEMISTRY (2018)

Article Chemistry, Multidisciplinary

Influence of fluorine substituents on the properties of phenylboronic compounds

Jan T. Gozdalik et al.

PURE AND APPLIED CHEMISTRY (2018)

Review Chemistry, Medicinal

Application of Fluorine in Drug Design During 2010-2015 Years: A Mini-Review

Bao-Cheng Wang et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2017)

Article Chemistry, Organic

Synthesis of polyfunctionalized 1,1'-(α,ω-alkanediyl)bis(1,2,3,4-tetrahydropyridines)

Natalya N. Gibadullina et al.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS (2017)

Proceedings Paper Chemistry, Multidisciplinary

Antifertility Compound from the Seeds of Carica papaya

Euis Julaeha et al.

3RD INTERNATIONAL SEMINAR ON CHEMISTRY 2014 (2015)

Review Chemistry, Multidisciplinary

The influence of fluorine in asymmetric catalysis

Dominique Cahard et al.

CHEMICAL SOCIETY REVIEWS (2014)

Article Chemistry, Medicinal

Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol

Gopalakrishnan Aridoss et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Chemistry, Organic

Aminocadambines A and B, two novel indole alkaloids from Neolamarckia cadamba

Ling-Li Liu et al.

TETRAHEDRON LETTERS (2010)

Article Biochemistry & Molecular Biology

Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials

Mridul Misra et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Chemistry, Physical

Heterocyclic analogues of cyclohexene: Theoretical studies of the molecular structures and ring-inversion processes

Svetlana V. Shishkina et al.

JOURNAL OF PHYSICAL CHEMISTRY A (2007)