Using fluoroform in trifluoromethylation reactions

Fluoroform (CF3H), a large-volume industrial by-product and potent greenhouse gas, has emerged as an attractive CF3 source for the development of tri-fluoromethylation reagents and reactions. This article highlights the recent reports since 2017 on the use of fluoroform in organic synthesis. Topics include direct trifluoromethylation facilitated by organic and inorganic bases, preparation of trifluoromethylation reagents based on transition metals and borazine, and radio -labelled fluoroform.

Automated summary

This article summarizes the latest research reports on the application of fluoroform in organic synthesis since 2017, including direct trifluoromethylation facilitated by organic and inorganic bases, preparation of trifluoromethylation reagents based on transition metals and borazine, and radio-labeled fluoroform.