Nephroprotective plant species used in traditional Mayan Medicine for renal-associated diseases

Article Chemistry, Multidisciplinary

Nephroprotective effect of ferulic acid on gentamicin-induced nephrotoxicity in female rats

Vasfiye Erseckin et al.

Summary: This study investigates the effect of ferulic acid on nephrotoxicity induced by gentamicin. The results show that ferulic acid can reduce inflammation and oxidative stress, protecting the kidneys.

DRUG AND CHEMICAL TOXICOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Finerenone Reduces Risk of Incident Heart Failure in Patients With Chronic Kidney Disease and Type 2 Diabetes: Analyses From the FIGARO-DKD Trial

Gerasimos Filippatos et al.

Summary: Finerenone reduces the incidence of new-onset HF and improves other HF outcomes in patients with chronic kidney disease and type 2 diabetes, regardless of a history of HF.

CIRCULATION (2022)

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Article Plant Sciences

Medicinal plants used in traditional Mayan medicine for the treatment of central nervous system disorders: An overview

Rodrigo Castaneda et al.

Summary: The study provides an overview of medicinal plants used by traditional healers and Mayan groups in Mesoamerica for CNS disorders, linking traditional use with pharmacological evidence. The research found 155 plants used for ethnopsychiatric conditions, with only 49 native species having reported pharmacological analyses. The study emphasizes the need for further research due to limited data on mechanism of action and lack of clinical studies.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Potential nephroprotective phytochemicals: Mechanism and future prospects

Parakh Basist et al.

Summary: This systematic review provides an in-depth look at nephroprotective phytoconstituents, including their mechanisms, sources, and clinical efficacy. The study identified several phytoconstituents with strong research evidence and a wide range of medicinal plant sources for nephroprotection. Further clinical studies are needed to enhance understanding of the pharmacodynamics and pharmacokinetics of these phytoconstituents, as well as to evaluate natural sources more specifically.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

In vitro and in vivo ameliorative effects of polyphenols from purple potato leaves on renal injury and associated inflammation induced by hyperuricemia

Rui Sun et al.

Summary: In this study, the ameliorative effects of polyphenols from purple potato leaves (PSPLP) on hyperuricemia were investigated. The results showed that PSPLP can effectively reduce uric acid levels, improve kidney function, and inhibit inflammation related to hyperuricemia. These findings provide a basis for further research and application of PSPLP as a functional food.

JOURNAL OF FOOD BIOCHEMISTRY (2022)

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Article Cell Biology

Naringenin alleviates hyperglycemia-induced renal toxicity by regulating activating transcription factor 4-C/EBP homologous protein mediated apoptosis

Mohammad Fareed Khan et al.

Summary: Naringenin attenuated ER stress marker protein expression, prevented ultrastructural changes in ER, inhibited nuclear translocation of ATF4 and CHOP, downregulated apoptotic marker protein expression, and ameliorated cellular and tissue damage in hyperglycemic renal toxicity.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2022)

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Article Chemistry, Applied

Seven compounds from Portulaca oleracea L. and their anticholinesterase activities

Wen Xu et al.

Summary: A novel lignan, named oleralignan A, along with six known compounds, was isolated from Portulaca oleracea L. for the first time. All seven compounds showed anticholinesterase activities in activity assay tests.

NATURAL PRODUCT RESEARCH (2022)

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Article

Bioactive compounds identification and physicochemical characterization from Nopalea cochenillifera (L.) Salm-Dyck cladodes flour

Héctor Enrique Fabela-Illescas et al.

Biotecnia (2022)

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Article Biotechnology & Applied Microbiology

Nephroprotective effect of polyphenol-rich extract of Costus spicatus in cisplatin-induced nephrotoxicity in Wistar albino rats

Amena Ali et al.

Summary: The polyphenol-rich extract of Costus spicatus leaves (PCSL) has been found to have nephroprotective potential, inhibiting cisplatin-induced nephrotoxicity in both in vitro and in vivo models. The extract showed significant improvement in serum biochemical markers and antioxidant enzymes, as well as inhibition of inflammatory cytokines. Histological analysis revealed that PCSL restored damaged kidney tissues.

3 BIOTECH (2022)

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Article Chemistry, Multidisciplinary

Protective effects of Bidens pilosa on hepatoxicity and nephrotoxicity induced by carbon tetrachloride in rats

Cristiane Martinez Ruiz Pegoraro et al.

Summary: The study demonstrated that Bidens pilosa effectively protected rats from the liver and kidney toxicity induced by carbon tetrachloride, and also exerted an antimutagenic effect.

DRUG AND CHEMICAL TOXICOLOGY (2021)

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Article Chemistry, Applied

Improvement of bioactive compounds content in granadilla (Passiflora ligularis) seeds after solid-state fermentation

Tacila R. J. Santos et al.

Summary: Fermentation using Aspergillus niger was conducted to increase bioactive compound content in granadilla seed flour. The highest phenolic and flavonoid contents were obtained with 80% acetone extraction from flour fermented for 48 hours at 50% initial moisture, while the highest antioxidant activity was achieved with 80% acetone extraction from flour fermented for 168 hours. The chromatographic analysis revealed an increase in certain compounds in the fermented flour extracts, with potential applications in various industries.

FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL (2021)

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Article Immunology

Reduced cutaneous inflammation associated with antioxidant action after topical application of the aqueous extract ofAnnona muricataleaves

Luana M. Cercato et al.

Summary: The aqueous extract of Annona muricata leaves shows anti-inflammatory and antioxidant effects, likely achieved by reducing reactive oxygen species release and modulating oxidative enzymes.

INFLAMMOPHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Gallic acid exerts anti-inflammatory, anti-oxidative stress, and nephroprotective effects against paraquat-induced renal injury in male rats

Ali Nouri et al.

Summary: The study evaluated the protective effect of gallic acid against paraquat-induced renal injury and oxidative stress in rats. Gallic acid treatment significantly increased renal antioxidant enzyme levels and decreased oxidative stress markers in serum. The results suggest that gallic acid can mitigate the toxic effects of paraquat exposure on renal tissue.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

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Article Environmental Sciences

Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity in rats

Enas M. Wans et al.

Summary: The study demonstrated that pre-treatment with corn silk methanolic extract (CSME) could protect rats against acetaminophen (APAP)-induced nephrotoxicity through its antioxidant, anti-apoptotic, and anti-inflammatory mechanisms.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Article Multidisciplinary Sciences

Cinnamic acid ameliorate gentamicin-induced liver dysfunctions and nephrotoxicity in rats through induction of antioxidant activities

Esmaeel Babaeenezhad et al.

Summary: This study found that cinnamic acid has significant protective effects against Gentamicin-induced liver and kidney dysfunctions in rats, mainly by reducing relevant markers levels and alleviating pathological changes through antioxidant activities.

HELIYON (2021)

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Article Chemistry, Medicinal

Administration of Herbarium Mixture (Guazuma ulmifolia/Tecoma stans) on Metabolic Profile in Type 2 Diabetes Mellitus Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Sara Pascoe-Gonzalez et al.

Summary: This study shows that the herbarium mixture (G. ulmifolia/T. stans) improved the glycemic profile in patients with T2DM.

JOURNAL OF MEDICINAL FOOD (2021)

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Article Integrative & Complementary Medicine

Ameliorative effect of Annona reticulata L. leaf extract on antihyperglycemic activity and its hepato-renal protective potential in streptozotocin induced diabetic rats

Vineela Pulivarthi et al.

Summary: This study focused on exploring the antihyperglycemic potential of Cherimoya leaves, showing significant inhibition of enzyme activity and improved blood sugar control in vitro and in vivo. GC-MS analysis revealed the presence of multiple bioactive compounds in MeEAR, providing potential leads for the development of anti-diabetic drugs.

JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE (2021)

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Article Immunology

Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-γ/TGF-β1/Smad3 pathway

Jie-Qiong Ma et al.

Summary: Bixin extracted from Bixa orellana seeds possesses anti-inflammatory, antioxidant, and anti-fibrosis properties by regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta 1/Smad3 pathways, improving renal damage induced by carbon tetrachloride in mice.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Plant Sciences

A review on phytochemistry and pharmacological uses of Tecoma stuns (L.) Juss. ex Kunth

Mukul Anand et al.

Summary: Tecoma stans, also known as yellow bells, is a popular plant in traditional Mexican medicine for treating various diseases. Current research is focused on evaluating its bioactive components and therapeutic potential.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Tagetes erecta L. flowers, a medicinal plant traditionally used to promote diuresis, induced diuretic and natriuretic effects in normotensive and hypertensive rats

Mariana Zanovello et al.

Summary: The hydroethanolic extract from Tagetes erecta demonstrated diuretic effects in both normotensive and hypertensive rats, with saccharides and triterpenes being the main compounds. It showed a natriuretic effect and a protective effect in reducing urinary calcium excretion, suggesting potential for the development of new pharmacological strategies for kidney disorders.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Catalytic Antioxidants in the Kidney

Yu Ah Hong et al.

Summary: Reactive oxygen and nitrogen species play crucial roles in kidney injuries, making antioxidant agents, especially catalytic antioxidants that mimic antioxidant enzymes, effective in combating oxidative stress-related kidney diseases. Research has shown the effectiveness of several catalytic antioxidants in treating disease models associated with oxidative stress.

ANTIOXIDANTS (2021)

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Article Urology & Nephrology

Population Estimates of GFR and Risk Factors for CKD in Guatemala

Ann C. Miller et al.

Summary: A population-representative survey conducted in two rural agricultural municipalities in Guatemala revealed that the majority of observed CKD cases were associated with diabetes and hypertension, emphasizing the urgent need to address the emerging epidemics of these conditions in rural areas. Additionally, an association between CKD and sugar cane cultivation in individuals living in poverty suggests the presence of CKD of unknown etiology in these communities, warranting further investigation.

KIDNEY INTERNATIONAL REPORTS (2021)

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Review Chemistry, Multidisciplinary

Natural products: potential treatments for cisplatin-induced nephrotoxicity

Chun-yan Fang et al.

Summary: Cisplatin is a clinically advanced anticancer drug, but its severe nephrotoxic effects limit its clinical use. There are currently no effective drugs for cisplatin-induced kidney injury, but natural products may have potential therapeutic effects.

ACTA PHARMACOLOGICA SINICA (2021)

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Article Biochemistry & Molecular Biology

Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF-kappa B-p65 signaling pathways

Fares E. M. Ali et al.

Summary: The study showed that UMB can protect rats against Cis-induced nephrotoxicity while enhancing its antitumor activity. UMB treatment improved renal function biomarkers, cytokines, and oxidant/antioxidant levels, suggesting its potential as an adjuvant therapy in Cis chemotherapeutic protocols.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

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Article Plant Sciences

Climate and categories: Two key elements for understanding the Mesoamerican hot-cold classification of illnesses and medicinal plants

Karina Yaredi Garcia-Hernandez et al.

Summary: This study examines the influence of climate on the hot-cold classification of diseases and medicinal plants in Mexico, finding differences in the hot-cold properties of diseases and plants under different climate conditions. Additional classification categories exist within the system and vary between regions and cultures.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Antihypertensive and vasorelaxant mode of action of the ethanol-soluble extract from Tagetes lucida Cav. aerial parts and its main bioactive metabolites

Samuel Estrada-Soto et al.

Summary: The study on the extract of Tagetes lucida Cav. confirms its antihypertensive properties, mainly achieved through vasorelaxant effect by activating the NO/cGMP system and calcium channel blockade. Additionally, active compounds like 6,7,8-trimethoxycoumarin also significantly contribute to vasorelaxation.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Nephroprotective and antilithiatic activities of Costus spicatus (Jacq.) Sw.: Ethnopharmacological investigation of a species from the Dourados region, Mato Grosso do Sul State, Brazil

Karyne Garcia Tafarelo Moreno et al.

Summary: The study found that Costus spicatus has significant nephroprotective and antilithiatic effects, reducing pathological damage and modulating tissue redox state in acute kidney injury and nephrolithiasis.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Purslane (Portulacae oleracea L.) attenuates cadmium-induced hepatorenal and colonic damage in mice: Role of chelation, antioxidant and intestinal microecological regulation

Xuena Tian et al.

Summary: The study demonstrated that Portulaca oleracea L. and purslane insoluble dietary fiber have beneficial effects against Cd-induced subchronic toxicity, potentially through anti-inflammatory, antioxidative, and regulation of intestinal microecology mechanisms.

PHYTOMEDICINE (2021)

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Review Medicine, General & Internal

Therapeutic Insights in Chronic Kidney Disease Progression

Amir Shabaka et al.

Summary: CKD has a significant impact on global morbidity and mortality through its effects on cardiovascular risk and end-stage kidney disease. Optimal management strategies for CKD include blood pressure control, treatment of albuminuria, avoidance of nephrotoxins and obesity, as well as new antihyperglycemic drugs and potassium-lowering therapies. Research efforts are now focusing on unraveling early disease mechanisms and developing novel therapeutic approaches targeting various aspects of CKD progression.

FRONTIERS IN MEDICINE (2021)

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Article Biology

Atheroprotective Properties of Costus spicatus (Jacq.) Sw. in Female Rats

Bethania Rosa Lorencone et al.

Summary: This study demonstrates that the extract of Costus spicatus has significant protective effects against the development of atherosclerosis, mainly through its hypolipidemic and antioxidant effects, which can slow down the progression of atherosclerotic disease.

LIFE-BASEL (2021)

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Article Biochemistry & Molecular Biology

Antihyperglycemic and Antilipidemic Properties of a Tea Infusion of the Leaves from Annona cherimola Miller on Streptozocin-Induced Type 2 Diabetic Mice

Jesus Martinez-Solis et al.

Summary: Tea infusion extracts from Annona cherimola leaves have shown antihyperglycemic and antilipidemic effects, especially IELAc-1.5 exhibited significant antihyperglycemic activity in treating diabetic mice. The presence of rutin in the extracts is suggested to contribute to their potential antidiabetic properties, highlighting the potential use of Annona cherimola tea infusions in diabetes treatment.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Nephroprotective and anti-inflammatory potential of aqueous extract from Persea americana seeds against cadmium-induced nephrotoxicity in Wistar rats

Olukemi Adetutu Osukoya et al.

Summary: The study found that AEPA significantly alleviated cadmium-induced kidney toxicity in Wistar rats, restored antioxidant status, and exhibited significant anti-inflammatory effects.

BIOMETALS (2021)

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Article Immunology

Juglanin protects against high fat diet-induced renal injury by suppressing inflammation and dyslipidemia via regulating NF-κB/HDAC3 signaling

Qiang Li et al.

Summary: The study showed that Jug could alleviate obesity-induced renal injury by suppressing the nuclear translocation of NF-kappa B and HDAC3, thus reducing inflammation and lipid accumulation, ultimately improving kidney function.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Environmental Sciences

Antioxidant and cytoprotective effects of avocado oil and extract (Persea americana Mill) against rotenone using monkey kidney epithelial cells (Vero)

Nelzi Ferreira Queiroz Junior et al.

Summary: Oxidative stress is implicated in the development of various diseases, and studying oxidative stress in vitro is crucial for finding new strategies to control it. Avocado extract and oil showed antioxidant and cytoprotective effects in monkey kidney epithelial cells exposed to rotenone, indicating a promising potential in decreasing oxidative stress.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2021)

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Article Pharmacology & Pharmacy

Protective effects of lutein against vancomycin-induced acute renal injury in mice via upregulation of peroxisome proliferator-activated receptor gamma/nuclear factor erythroid 2-related factor 2 and inhibition nuclear factor-kappaB/caspase 3

Promise M. Emeka et al.

Summary: Lutein can protect against vancomycin-induced acute renal injury by potentially upregulating PPAR gamma/Nrf2 expression in renal tissues, consequently reducing inflammation pathway by NF-kappa B and apoptosis pathway by caspase-3.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2021)

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Editorial Material Medicine, General & Internal

FDA approval of dapagliflozin for chronic kidney disease: a remarkable achievement? Comment

Tazeen H. Jafar

LANCET (2021)

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Review Urology & Nephrology

Sodium-glucose cotransporter-2 inhibitors and non-steroidal mineralocorticoid receptor antagonists: Ushering in a new era of nephroprotection beyond renin-angiotensin system blockade

Srinivas Vinayak Shenoy et al.

Summary: Traditional treatments for CKD have been limited, but the introduction of SGLT2 inhibitors and MRAs in recent years has brought new hope for CKD patients, showing renal benefits in patients with diabetic CKD and potentially becoming the standard of care for CKD in the future.

NEPHROLOGY (2021)

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Review Immunology

NLRP3 Inflammasome in Metabolic-Associated Kidney Diseases: An Update

Wei Xiong et al.

Summary: Metabolic syndrome can lead to metabolic disorders and impair kidney structure and function, while persistent inflammation exacerbates renal damage. Inflammasomes are key in initiating inflammation, and understanding their role in kidney damage caused by metabolic disorders can provide new therapeutic perspectives for kidney diseases.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Acute kidney injury

John A. Kellum et al.

Summary: Acute kidney injury (AKI) describes a sudden loss of kidney function which can lead to long term damage. AKI and AKD are global issues with different causes and management strategies in various regions. Prevention and early detection of AKI are crucial for better outcomes.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Plant Sciences

Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence

Noureddine Bencheikh et al.

Summary: In this study, an ethnobotanical survey was conducted in a remote area of North-Eastern Morocco to investigate traditional medicinal plants used to treat kidney diseases. A total of 121 plant species from 57 botanical families were identified, with Asteraceae, Lamiaceae, and Apiaceae being the most represented families. The study found correlations between traditional plant use and well-studied pharmacological evidence, providing valuable insights for potential biologically active compound research.

PLANTS-BASEL (2021)

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Article Biochemistry & Molecular Biology

Jatropha curcas Leaf Extract and Fractions Attenuate Hyperglycemia, Tissue Oxidation, and Kidney Dysfunction in Diabetic Rats

Atamgba Agbor Asuk et al.

Summary: The study showed that Jatropha curcas leaf extract has significant effects in lowering blood glucose and improving kidney function in diabetic rats, as well as reducing oxidative stress induced by hyperglycemia. Additionally, it can help regulate electrolyte levels in the body.

JOURNAL OF BIOCHEMICAL TECHNOLOGY (2021)

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Article Integrative & Complementary Medicine

The antioxidant and anti-inflammatory effects of Carica Papaya Linn. seeds extract on CCl4-induced liver injury in male rats

Nadia Z. Shaban et al.

Summary: The study demonstrated that Carica Papaya Linn. seeds extract (SE) has potent antioxidant activities and shows protective and therapeutic effects against liver toxicity induced by carbon tetrachloride (CCl4). SE attenuated oxidative stress, inflammation, fibrosis, and apoptosis induced by CCl4, leading to improved liver and kidney functions. These results suggest that SE could be used as a pharmacological tool for anti-hepatotoxicity purposes.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2021)

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Article Toxicology

Cnidoscolus aconitifolius leaf extract and ascorbate confer amelioration and protection against dimethyl nitrosamine-induced renal toxicity and testicular abnormalities in rats

Oluwatobi T. Somade et al.

Summary: The extracts of Cnidoscolus aconitifolius and ascorbate showed comparable ameliorative and protective effects against DMN-induced renal and testicular toxicities in rats.

TOXICOLOGY REPORTS (2021)

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Article Toxicology

Comparison between Annona squamosa, Annona cherimolia and Annona atemoya ethanolic extracts extenuative impact against oxidative stress, inflammation and apoptosis in rat kidney induced by Ifosfamid

Areeg Abd-Elrazek et al.

Summary: The study demonstrates the protective effects of different Annona species extracts against IFO-induced renal injury by modulating inflammatory and apoptotic markers, suggesting their potential in ameliorating renal toxicity.

TOXICOLOGY RESEARCH (2021)

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Article Medicine, Research & Experimental

Gallic Acid Exerts Nephroprotective, Anti-Oxidative Stress, and Anti-Inflammatory Effects Against Diclofenac-Induced Renal Injury in Malerats

Alireza Moradi et al.

Summary: The study evaluated the effects of gallic acid on diclofenac-induced renal injury in rats, showing significant improvements in oxidative stress and serum biochemical parameters, as well as histological changes.

ARCHIVES OF MEDICAL RESEARCH (2021)

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Letter Urology & Nephrology

Effects of pirfenidone on renal function in patients with interstitial pneumonia

Jun Matsumoto et al.

RENAL FAILURE (2021)

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Article Public, Environmental & Occupational Health

Diabetic kidney disease: An overview of prevalence, risk factors, and biomarkers

Salman Hussain et al.

Summary: Diabetic kidney disease (DKD) is a major public health problem characterized by elevated urine albumin excretion or reduced glomerular filtration rate. The pathophysiology involves various pathways, and timely diagnosis and appropriate interventions are crucial for dealing with this condition.

CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH (2021)

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Article Environmental Sciences

Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-κB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways

Emad H. M. Hassanein et al.

Summary: This study demonstrates that umbelliferone has a protective effect against gentamicin-induced nephrotoxicity by improving kidney function and histological changes. Umbelliferone regulates multiple biomarkers and protein expressions to suppress inflammation pathways associated with nephrotoxicity.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in rats

Zuhal Uckun et al.

DRUG AND CHEMICAL TOXICOLOGY (2020)

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Article Peripheral Vascular Disease

The effects of soursop supplementation on blood pressure, serum uric acid, and kidney function in a prehypertensive population in accordance with the 2017 ACC/AHA guideline

Haidar Alatas et al.

JOURNAL OF HUMAN HYPERTENSION (2020)

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Article Chemistry, Applied

Mutamba (Guazuma ulmifolia Lam.) fruit as a novel source of dietary fibre and phenolic compounds

Gustavo Araujo Pereira et al.

FOOD CHEMISTRY (2020)

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Article Plant Sciences

Value Chain Analysis of Chaya (Mayan Spinach) in Guatemala

Nadezda Amaya et al.

ECONOMIC BOTANY (2020)

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Article Biochemistry & Molecular Biology

Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

Alberto Hernandez-Leon et al.

MOLECULES (2020)

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Editorial Material Urology & Nephrology

The impact of chronic kidney disease on global health

Ellen F. Carney

NATURE REVIEWS NEPHROLOGY (2020)

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Article Biochemistry & Molecular Biology

Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats

Tajdar Husain Khan et al.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2020)

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Article Food Science & Technology

Downregulation of proinflammatory liver gene expression by Justicia spicigera and kaempferitrin in a murine model of obesity-induced by a high-fat diet

Samantha Alejandra Real-Sandoval et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Review Cell Biology

Diverse Role of TGF-beta in Kidney Disease

Yue-Yu Gu et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Cell Biology

Role of Inflammasomes in Kidney Diseases via Both Canonical and Non-canonical Pathways

Huiling Xiang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Roles of Nrf2 in Protecting the Kidney from Oxidative Damage

Masahiro Nezu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Plant Sciences

Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit

Geisla Teles Vieira et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Review Plant Sciences

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

David J. Newman et al.

JOURNAL OF NATURAL PRODUCTS (2020)

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Article Biotechnology & Applied Microbiology

Kaempferol ameliorates Cisplatin induced nephrotoxicity by modulating oxidative stress, inflammation and apoptosis via ERK and NF-κB pathways

Zhu Wang et al.

AMB EXPRESS (2020)

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Review Biochemistry & Molecular Biology

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Liam Baird et al.

MOLECULAR AND CELLULAR BIOLOGY (2020)

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Review Endocrinology & Metabolism

Mechanisms of Herbal Nephroprotection in diabetes mellitus

Dorin Dragos et al.

JOURNAL OF DIABETES RESEARCH (2020)

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Review Pharmacology & Pharmacy

Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

Matthias S. Geck et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Agriculture, Multidisciplinary

Bixin Confers Prevention against Ureteral Obstruction-Caused Renal Interstitial Fibrosis through Activation of the Nuclear Factor Erythroid-2-Related Factor2 Pathway in Mice

Jianzhong Li et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

SIRT1 Activation by Equisetum arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats

Csaba Hegedus et al.

MOLECULES (2020)

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Editorial Material Plant Sciences

Maya Medicinal Fruit Trees: Q'eqchi' Homegarden Remedies

Amanda M. Thiel et al.

ECONOMIC BOTANY (2020)

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Article Agricultural Engineering

Chenopodium ambrosioides var. ambrosioides leaf extracts possess regenerative and ameliorative effects against mercury-induced hepatotoxicity and nephrotoxicity

Gbenga S. Ogunleye et al.

INDUSTRIAL CROPS AND PRODUCTS (2020)

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Article Food Science & Technology

Hypouricemic effect in hyperuricemic mice and xanthine oxidase inhibitory mechanism of dietary anthocyanins from purple sweet potato (Ipomoea batatas L.)

Yang Yang et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Article Cell Biology

Bixin Protects Against Kidney Interstitial Fibrosis Through Promoting STAT6 Degradation

Jianzhong Li et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Toxicology

Chromolaena odorata flavonoids attenuate experimental nephropathy: Involvement of pro-inflammatory genes downregulation

Olaposi Idowu Omotuyi et al.

TOXICOLOGY REPORTS (2020)

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Article Chemistry, Medicinal

Protective Effect of Carica papaya Leaf Extract against Mercuric Chloride-Induced Nephrotoxicity in Wistar Rats

Yuvaraj Maria Francis et al.

PHARMACOGNOSY MAGAZINE (2020)

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Review Urology & Nephrology

Mitochondrial dysfunction in kidney injury, inflammation, and disease: potential therapeutic approaches

Divya Bhatia et al.

KIDNEY RESEARCH AND CLINICAL PRACTICE (2020)

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Article Tropical Medicine

Renoprotective effect of umbelliferone in high-fat diet/streptozotocin-induced type 2 diabetic rats

Jarinyaporn Naowaboot et al.

ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE (2020)

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Article Pharmacology & Pharmacy

Ameliorative effect of extract of Tecoma stans (L.) Juss. ex kunth leaves against CCl4- and acetaminophen-induced liver damage in rats

C. Larbie et al.

ADVANCES IN TRADITIONAL MEDICINE (2020)

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Review Urology & Nephrology

PPARγ and Its Agonists in Chronic Kidney Disease

Yuhua Ma et al.

INTERNATIONAL JOURNAL OF NEPHROLOGY (2020)

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Article Biotechnology & Applied Microbiology

Oxidative Stress in Animal Models of Acute and Chronic Renal Failure

Marianna Gyuraszova et al.

DISEASE MARKERS (2019)

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Article Plant Sciences

Traditional oriental medicine for sensorineural hearing loss: Can ethnopharmacology contribute to potential drug discovery?

Rodrigo Castaneda et al.

JOURNAL OF ETHNOPHARMACOLOGY (2019)

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Article Food Science & Technology

Determination of phenolic compounds and antioxidant activity in passion fruit pulp (Passiflora spp.) using a modified QuEChERS method and UHPLC-MS/MS

Eliza Mariane Rotta et al.

LWT-FOOD SCIENCE AND TECHNOLOGY (2019)

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Article Biochemistry & Molecular Biology

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Preventive Effect of an Infusion of the Aqueous Extract of Chaya Leaves (Cnidoscolus aconitifolius) in an Aberrant Crypt Foci Rat Model Induced by Azoxymethane and Dextran Sulfate Sodium

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Rutin protects mercuric chloride-induced nephrotoxicity via targeting of aquaporin 1 level, oxidative stress, apoptosis and inflammation in rats

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Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress

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Naringenin Ameliorates Renovascular Hypertensive Renal Damage by Normalizing the Balance of Renin-Angiotensin System Components in Rats

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BULLETIN OF THE WORLD HEALTH ORGANIZATION (2018)

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PKC-α contributes to high NaCl-induced activation of NFAT5 (TonEBP/OREBP) through MAPK ERK1/2

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Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney

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Antioxidant activity and phenolic compounds of fractions from Portulaca oleracea L

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β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner

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Antihyperglycaemic effects of ethanol extracts of Carica papaya and Pandanus amaryfollius leaf in streptozotocin-induced diabetic mice

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Zea mays L. extracts modify glomerular function and potassium urinary excretion in conscious rats

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Naringenin attenuates cisplatin nephrotoxicity in rats

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Norbixin ingestion did not induce any detectable DNA breakage in liver and kidney but caused a considerable impairment in plasma glucose levels of rats and mice

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Hypoglycemic effect of Equisetum myriochaetum aerial parts on streptozotocin diabetic rats

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

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Nephroprotective plant species used in traditional Mayan Medicine for renal-associated diseases

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