4.5 Article

ATP-responsive zeolitic imidazolate framework-90 for superoxide dismutase delivery to reduce reactive oxygen species in MG-63 cells

Related references

Note: Only part of the references are listed.
Article Chemistry, Physical

Space-confined growth of nanoscale metal-organic frameworks/Pd in hollow mesoporous silica for highly efficient catalytic reduction of 4-nitrophenol

Xiaojing Huang et al.

Summary: In this study, a stepwise vacuum evaporation strategy was developed to achieve the nano-confined growth of metal-organic frameworks (MOFs) in hollow mesoporous silica nanospheres (HMSN). The catalytic performance of the resulting catalyst was significantly enhanced through further functionalization.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2023)

Article Medicine, Research & Experimental

Dual antisense oligonucleotide targeting miR-21/miR-155 synergize photodynamic therapy to treat triple-negative breast cancer and inhibit metastasis

Mengdi Shang et al.

Summary: This study developed a strategy using nanoparticles to co-deliver antisense oligonucleotides and photosensitizers into tumor cells, effectively inhibiting proliferation and metastasis of triple negative breast cancer cells.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Article Engineering, Environmental

Visual naked-eye detection of SARS-CoV-2 RNA based on covalent organic framework capsules

Minghui Wang et al.

Summary: The outbreak of COVID-19 has emphasized the importance of new diagnostic technologies. This research introduces a novel COF capsule design for naked-eye detection of SARS-CoV-2 RNA, demonstrating exceptional analytical performance and promising applications.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Chemistry, Multidisciplinary

ATP-responsive near-infrared fluorescent nanoparticles for synergistic chemotherapy and starvation therapy

Xi-Xi Chen et al.

Summary: This study developed MOF-based nanoparticles that can achieve controlled drug delivery and synergistic therapy. These nanoparticles are destructed in cancer cells, releasing fluorescent substances and achieving drug delivery and starvation therapy, with excellent anti-tumor efficiency.

NANOSCALE (2022)

Article Multidisciplinary Sciences

Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome

Claudia Montllor-Albalate et al.

Summary: Cu/Zn superoxide dismutase (Sod1) acts as an important antioxidant enzyme, promoting NADPH production and balancing glycolytic and oxPPP flux by controlling GAPDH activity to adapt to life in air. Sod1-derived H2O2 is crucial for antioxidant defense and serves as a master regulator of metabolism and the thiol redoxome, impacting numerous metabolic enzymes.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Nanoscience & Nanotechnology

Fabricating Bimetal Organic Material Capsules with a Commodious Microenvironment and Synergistic Effect for Glycosyltransferase

Meng Qiao et al.

Summary: Metal-organic frameworks (MOFs) are rarely used as solid supports in the enzymatic synthesis of oligosaccharides and polysaccharides due to compatibility issues and limited mass transfer. In this study, bimetal organic material (BMOM) microreactors were prepared to encapsulate Pasteurella multocida heparosan synthase 2 (PmHS2), enabling successful synthesis of heparosan disaccharide, oligosaccharide, and polysaccharide with high yield.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Chemistry, Multidisciplinary

Herpesvirus-Mimicking DNAzyme-Loaded Nanoparticles as a Mitochondrial DNA Stress Inducer to Activate Innate Immunity for Tumor Therapy

Xiu Zhao et al.

Summary: By mimicking the structure and infection processes of herpesvirus, a herpesvirus-mimicking nanoparticle named Vir-ZM@TD has been engineered for effective tumor therapy, showing promising results in inducing innate immunity and enhancing the survival time of tumor-bearing mice.

ADVANCED MATERIALS (2022)

Article Biophysics

Lactate dehydrogenase encapsulated in a metal-organic framework: A novel stable and reusable biocatalyst for the synthesis of D-phenyllactic acid

Yifeng Wang et al.

Summary: In this study, a novel biocatalyst was synthesized by encapsulating lactate dehydrogenase (LDH) in the metalorganic framework ZIF-90. The LDH@ZIF-90 showed strong biological activity and enhanced tolerance to temperature, pH, and organic solvents. It also exhibited good reusability, making it a promising biocatalyst for the synthesis of D-phenyllactic acid (D-PLA).

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

Article Chemistry, Inorganic & Nuclear

Post-synthesis functionalization of ZIF-90 with sulfonate groups for high proton conduction

Yu-Xiang Lian et al.

Summary: Introducing sulfonic acid groups into MOF materials is an effective method for enhancing proton conduction. In this study, a partially functionalized ZIF-90-SO3Na(2.3) material was successfully prepared, which exhibited high proton conductivity under high humidity and high temperature conditions.

DALTON TRANSACTIONS (2022)

Article Chemistry, Multidisciplinary

COF-based nanoreactors for click-activated prodrug delivery and precise anti-vascular therapy

Peng Wang et al.

Summary: A new click-activated prodrug, CA4V, and a bioorthogonal nanoreactor, CA4V/ZIF-90@TzCOF@Apt, are reported. The nanoreactor, consisting of a ZIF-90 core, COF shells, and an aptamer polymer coating, induces a nanoconfined bioorthogonal reaction, enhancing the activation efficiency of CA4V and its therapeutic effects in vivo.

CHEMICAL COMMUNICATIONS (2022)

Article Materials Science, Biomaterials

Superoxide dismutase-embedded metal-organic frameworks via biomimetic mineralization for the treatment of inflammatory bowel disease

Shaowei Bai et al.

Summary: This study successfully constructed a nanocomposite for the treatment of inflammatory bowel disease by encapsulating superoxide dismutase into a specific nanomaterial. The composite showed efficient suppression of inflammation and demonstrated therapeutic effects in an experimental model.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Article Chemistry, Multidisciplinary

ZIF-90 with biomimetic Zn-N coordination structures as an effective nanozyme to mimic natural hydrolase

Chaoyu Fan et al.

Summary: Inspired by the structures of enzymes, researchers have developed a fast and robust method to generate ZIF-90 metallo-nanozymes. ZIF-90 exhibits enzyme-like activity, high stability, and recyclability.

NANOSCALE (2022)

Article Materials Science, Biomaterials

A bone-targeting drug delivery vehicle of a metal-organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis

Ting Ge et al.

Summary: This paper proposes a drug delivery platform that targets bone tumors by loading anti-cancer drugs into nanoparticles. The experimental results show that these nanoparticles can inhibit the growth of tumor cells and have a good therapeutic effect.

BIOMATERIALS SCIENCE (2022)

Review Biochemistry & Molecular Biology

Strategies to expand the therapeutic potential of superoxide dismutase by exploiting delivery approaches

Arianna Carolina Rosa et al.

Summary: The review discusses the potential harms of overproduction of free radicals and the importance of SOD supplementation in reducing oxidative stress. It also explores various methods and strategies to improve the bioavailability of SOD in recent years.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Review Pharmacology & Pharmacy

Targeting reactive oxygen species in stem cells for bone therapy

Xin Li et al.

Summary: Reactive oxygen species (ROS) play a crucial role in regulating bone homeostasis, with potential therapeutic strategies targeting ROS showing promise in improving bone health.

DRUG DISCOVERY TODAY (2021)

Article Biochemistry & Molecular Biology

Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment

Yuteng Weng et al.

Summary: Periodontitis is the sixth most prevalent disease globally, closely related to systemic diseases and impacting overall health. It is characterized by irreversible alveolar bone loss and activated osteoclastogenic process, which may be linked to the activation of intracellular reactive oxygen species (ROS) in osteoclasts.

REDOX BIOLOGY (2021)

Article Chemistry, Analytical

Enzyme-Encapsulated Zeolitic Imidazolate Frameworks Formed Inside the Single Glass Nanopore: Catalytic Performance and Sensing Application

Mengya Cao et al.

Summary: This study immobilized enzymes inside glass nanopores to study their catalytic activity and stability in a Metal-organic framework (MOF) environment. The change in transmembrane ion current was monitored to observe the enzyme catalysis in real time. The effects of MOF structure on enzyme activity and stability were also investigated, providing a novel design for studying enzymatic catalysis in confined environments with potential applications in various fields.

ANALYTICAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

In-gel SOD assay reveals SOD-2 is the single active, water-soluble SOD enzyme in C. elegans

Lourds M. Fernando et al.

Summary: The nematode C. elegans has five sod genes, but only the mitochondrial SOD shows activity in the water-soluble fraction, with lower activity compared to multiple active SODs in D. melanogaster and E. coli.

FREE RADICAL RESEARCH (2021)

Review Cell Biology

Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat

Gloria E. Villalpando-Rodriguez et al.

Summary: Reactive oxygen species (ROS) are crucial for cellular signaling and stress response, with different levels and types affecting a cell's ability to undergo cell death and being associated with dysregulation of antioxidant pathways. Cell death can occur through various mechanisms, with ROS playing essential roles in different types of cell death and controlling the mechanisms involved.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Medicine, Research & Experimental

ATP-triggered mitochondrial cascade reactions for cancer therapy with nanoscale zeolitic imidazole framework-90

Wei Pan et al.

Summary: The utilization of ATP-triggered strategy with nanoscale ZIF-90 to initiate mitochondrial cascade reactions for cancer therapy is crucial, leading to continuous oxidative stress and apoptosis of cancer cells.

THERANOSTICS (2021)

Review Materials Science, Biomaterials

Superoxide dismutase nanozymes: an emerging star for anti-oxidation

Hanqing Zhao et al.

Summary: Superoxide dismutases (SODs) play a crucial role in combating damage from reactive oxygen species in oxidative stress-related diseases. Nanozymes, as substitutes for SODs, offer better stability and cost-effectiveness.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Review Immunology

Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

George Hajishengallis et al.

Summary: Periodontitis is causally linked to the development of other chronic inflammatory diseases outside the oral mucosa, and intervention studies have shown that local treatment of periodontitis can ameliorate surrogate markers of comorbid conditions. Experimental animal studies have further strengthened the potential causal link by establishing biologically plausible and clinically consistent mechanisms. Understanding the impact of disseminated periodontal pathogens and systemic inflammation associated with periodontitis on extra-oral pathologies may lead to new therapeutic options to reduce the risk of periodontitis-associated comorbidities.

NATURE REVIEWS IMMUNOLOGY (2021)

Review Dentistry, Oral Surgery & Medicine

Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way

Fabio Sa Carneiro Sczepanik et al.

PERIODONTOLOGY 2000 (2020)

Review Biochemistry & Molecular Biology

Immunomodulatory Effects of MSCs in Bone Healing

Dalia Medhat et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Chemistry, Multidisciplinary

Enhanced Activity of Enzymes Encapsulated in Hydrophilic Metal-Organic Frameworks

Weibin Liang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Review Biochemistry & Molecular Biology

Reactive Oxygen Species and Oncoprotein Signaling-A Dangerous Liaison

Stephen Jun Fei Chong et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Chemistry, Multidisciplinary

Targeting superoxide dismutase to endothelial caveolae profoundly alleviates inflammation caused by endotoxin

Vladimir V. Shuvaev et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Article Chemistry, Multidisciplinary

Water-Based Synthesis of Zeolitic Imidazolate Framework-90 (ZIF-90) with a Controllable Particle Size

Fa-Kuen Shieh et al.

CHEMISTRY-A EUROPEAN JOURNAL (2013)

Article Medical Laboratory Technology

Human plasma ATP concentration

Mark W. Gorman et al.

CLINICAL CHEMISTRY (2007)

Article Dentistry, Oral Surgery & Medicine

Local delivery of liposome-encapsulated superoxide dismutase and catalase suppress periodontal inflammation in beagles

M Petelin et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2000)