Economic losses associated with mastitis due to bovine leukemia virus infection

Bovine leukemia virus (BLV), which causes enzootic bovine leukosis and immunosuppression, is widely prev-alent on Japanese dairy farms. However, in the absence of a national eradication scheme with compensation programs, it is important to estimate BLV-associated economic losses to raise farmers' awareness. Mastitis (includes both clinical and subclinical) is a common disease in the dairy industry and the most common reason for culling. We hypothesized that immunosup-pression due to BLV predisposes subclinical mastitis. A retrospective cohort study was conducted to trace Hol-stein cows at 9 commercial dairy farms in the Nemuro and Kushiro regions of Hokkaido Prefecture, Japan, where monitoring of BLV proviral load is routine. Infor-mation regarding Dairy Herd Improvement data, parity number, and delivery day was collected at each farm. Cows with no confirmed infection with BLV during lac-tation were defined as non-infected. Low-proviral-load and high-proviral-load (H-PVL) cows were defined as those in which proviral load was below and over 2,465 copies/50 ng of DNA, respectively, or 56,765 copies/105 cells, respectively, throughout the lactation period. Survival analysis was performed using the frailty model to estimate the hazard ratio of subclinical mastitis for BLV infection status using data from 1,034 dairy cows after adjusting for parity number and delivery season as confounding factors. Kaplan-Meier survivor curves demonstrated that half of the H-PVL cows developed subclinical mastitis within 52 d after calving. The haz-ard ratio of subclinical mastitis for H-PVL cows was 2.61 times higher than that of non-infected cows. In 2017, there were 264,443 clinical mastitis cases in Hok-kaido. Using field and published data, annual economic losses were estimated using Monte Carlo simulation. The economic loss due to mastitis associated with BLV infection per H-PVL cow was $418.59 ( yen 43,952), with the annual economic loss in Hokkaido Prefecture due to mastitis caused by BLV infection estimated at $6,097,225 ( yen 640,208,633). In summary, H-PVL cows were more susceptible to subclinical mastitis than non -infected and low-proviral-load cows, and mastitis due to BLV infection was projected to cause significant economic losses.

Automated summary

Bovine leukemia virus (BLV) is prevalent on Japanese dairy farms and causes bovine leukosis and immunosuppression. This study found that cows with high proviral load of BLV were more susceptible to subclinical mastitis than non-infected and low-proviral-load cows, leading to significant economic losses.