☆ 4.8 Review

Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery

JOURNAL OF CONTROLLED RELEASE (2022)

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody

Zhilin Li et al.

Summary: To improve the response rate of immune checkpoint inhibitors in immunosuppressive cancers, a self-amplified biomimetic nanosystem was constructed to induce immunogenic cell death at tumor sites. The nanosystem effectively reverses the immunosuppressive tumor microenvironment, leading to distinctive inhibition of tumor growth and metastasis when combined with immune checkpoint inhibitors.

BIOACTIVE MATERIALS (2023)

Add to Collection
Article Biochemistry & Molecular Biology

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

Sam Afkhami et al.

Summary: The study found that using adenoviral vectors with a multivalent vaccine through intranasal immunization can generate better mucosal immune responses, including local and systemic antibody responses, mucosal tissue-resident memory T cells, and mucosal trained innate immunity, and provide protection against multiple viral variants.

CELL (2022)

Add to Collection
Article Pharmacology & Pharmacy

Hyaluronic acid-modified redox-sensitive hybrid nanocomplex loading with siRNA for non-small-cell lung carcinoma therapy

Daoyuan Chen et al.

Summary: A novel hybrid nanocomplex, HA-SeSe-COOH/siR-93C@PAMAM, was constructed for efficient delivery of siRNA into tumor cells via a redox-mediated intracellular disassembly. This nanocomplex showed high stability and controlled zeta potential, and displayed GSH/ROS dual responsive properties. In vitro and in vivo studies demonstrated its low cytotoxicity, rapid lysosomal escape, significant transfection efficiency, and improved inhibition of tumor growth.

DRUG DELIVERY (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Pulmonary delivery of mucosal nanovaccines

Wei Tang et al.

Summary: Mucosal vaccination has the potential to address mucosal immune diseases, prevent infections, and treat systemic immune disorders. Recent advancements in pulmonary mucosal nanovaccines leverage nanoparticle delivery technologies to trigger robust immune protection against various mucosal diseases.

NANOSCALE (2022)

Add to Collection
Article Multidisciplinary Sciences

Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

Min Qiu et al.

Summary: The challenge of delivering mRNA to specific organs and cells in vivo is being addressed, with research showing that N-series LNPs can selectively deliver mRNA to the lungs while O-series LNPs tend to deliver mRNA to the liver. By analyzing the protein corona on targeted LNPs, unique plasma proteins were identified that contribute to their targetability. This research demonstrates the potential of LNPs as a promising therapeutic intervention for lung diseases like lymphangioleiomyomatosis.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Add to Collection
Review Engineering, Biomedical

Physicochemical properties of nanoparticles affecting their fate and the physiological function of pulmonary surfactants

Qiaoyu Liu et al.

Summary: This review summarizes how the physicochemical properties of nanoparticles affect the physiological function and fate of pulmonary surfactants. The composition and characteristics of pulmonary surfactants, as well as the methods for studying their interaction with nanoparticles, are introduced. The influence of nanoparticles' physicochemical properties on hydrophobic protein adsorption and strategies to decrease their interaction with pulmonary surfactants are discussed. The influence of nanoparticles' physicochemical properties on lipids and hydrophilic protein adsorption and their consequent fate is described.

ACTA BIOMATERIALIA (2022)

Add to Collection
Article Engineering, Biomedical

The influence of a biomimetic pulmonary surfactant modification on the in vivo fate of nanoparticles in the lung

Qiaoyu Liu et al.

Summary: In this study, the biomimetic modification of nanoparticles with endogenous surfactants was investigated to improve biocompatibility and minimize lung damage. Different phospholipids were used to modify paclitaxel (PTX)-loaded nanoparticles, leading to mucoadhesive or mucus penetration properties. The modification affected the uptake by different cells in the lung and retention in bronchoalveolar lavage fluid, as well as PTX absorption in the lung tissue. The findings provide insights for the design of inhalable nanocarriers.

ACTA BIOMATERIALIA (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Targeted Drug/Gene/Photodynamic Therapy via a Stimuli-Responsive Dendritic-Polymer-Based Nanococktail for Treatment of EGFR-TKI-Resistant Non-Small-Cell Lung Cancer

Jinxing Huang et al.

Summary: This study proposes a nanococktail therapeutic strategy for treating EGFR-TKI resistant NSCLC by targeted co-delivery of drugs and genes, along with photodynamic therapy. The results show that this nanococktail therapy effectively releases drugs and genes at the tumor site, demonstrating potent antitumor efficacy.

ADVANCED MATERIALS (2022)

Add to Collection
Article Pharmacology & Pharmacy

Elucidating inhaled liposome surface charge on its interaction with biological barriers in the lung

Jing Zhao et al.

Summary: The surface charge of liposomes is a crucial factor in modulating their interaction with biological barriers in the lung and their fate after inhalation. Neutral and negatively charged liposomes show improved safety and lung retention properties, while positively charged liposomes are unstable in the lung microenvironment and may lead to systemic exposure.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs

Samuel T. LoPresti et al.

Summary: This study demonstrates that by replacing different helper lipids in lipid nanoparticles, the targeting and protein expression distribution of the nanoparticles can be altered, allowing for non-hepatocellular mRNA delivery to extrahepatic organs. These findings provide new insights for the expansion of mRNA therapeutics.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Current state of the art in peptide-based gene delivery

Roja Hadianamrei et al.

Summary: Gene therapy involves correcting specific pathological conditions by introducing exogenous genetic materials into cells. However, efficient delivery of these materials is hindered by various barriers, necessitating the use of gene vectors. Peptides have emerged as promising biomaterials for gene delivery due to their desirable properties. This review provides an overview of recent advances in peptide-based gene delivery systems and focuses on systems composed solely of peptides.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes

Domizia Baldassi et al.

Summary: This study developed a siRNA delivery system targeting lung epithelial cells, which effectively suppressed the replication of SARS-CoV-2 both in vitro and ex vivo without toxic or immunogenic side effects.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection
Review Pharmacology & Pharmacy

Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome

Makhloufi Zoulikha et al.

Summary: siRNA has potential for treating acute lung injury/acute respiratory distress syndrome by modifying gene expression, but effective delivery remains a challenge.

ACTA PHARMACEUTICA SINICA B (2022)

Add to Collection
Review Biotechnology & Applied Microbiology

Viral vector-based gene therapies in the clinic

Zongmin Zhao et al.

Summary: Gene therapies using viral vectors have shown promising outcomes in treating various diseases that were once considered incurable. The use of viral vectors allows for efficient delivery of gene therapeutics into target cells, leading to the approval of multiple products and ongoing clinical trials exploring their therapeutic potential.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2022)

Add to Collection
Article Pharmacology & Pharmacy

Inhaled therapy for COVID-19: Considerations of drugs, formulations and devices

Tushar Saha et al.

Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, has spread rapidly worldwide. While vaccines are available, effective antiviral treatments are still lacking. Inhaled therapy is being considered as an efficient approach for COVID-19, allowing higher concentrations of drugs in the lungs to increase potency and reduce the likelihood of drug-resistant variants. However, appropriate drug combinations and delivery devices are crucial for successful treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Nanoparticle Delivery Systems with Cell-Specific Targeting for Pulmonary Diseases

Zicheng Deng et al.

Summary: Nanoparticle delivery systems have been developed to address critical issues in the treatment of respiratory disorders, offering unique drug release capabilities and cell-targeting specificity. Low toxicity and high degradability are key requirements in nanoparticle design.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

Add to Collection
Article Pharmacology & Pharmacy

Aerosolizable siRNA-encapsulated solid lipid nanoparticles prepared by thin-film freeze-drying for potential pulmonary delivery

Jie-Liang Wang et al.

Summary: Lipid nanoparticles can be transformed into aerosolizable dry powder by thin-film freeze-drying (TFFD), which preserves their physical properties and siRNA functionality. Dry powders prepared by TFFD show better aerosol performance properties compared to those prepared by spray drying.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Add to Collection
Review Pharmacology & Pharmacy

Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs

Yuta Suzuki et al.

Summary: Nucleic acid therapeutics are evolving into precise medicines that can manipulate specific genes, with the challenge of developing safe and effective delivery systems for target cells. Lipid nanoparticles (LNPs) have provided a revolutionary delivery system allowing for the clinical translation of RNA-based candidates. LNPs enabled the development of two SARS-CoV-2 mRNA vaccines during the COVID-19 outbreak in 2020.

DRUG METABOLISM AND PHARMACOKINETICS (2021)

Add to Collection
Article Medicine, Research & Experimental

GALA-Modified Lipid Nanoparticles for the Targeted Delivery of Plasmid DNA to the Lungs

Yuta Hagino et al.

Summary: This study developed lipid nanoparticles (LNPs) for targeted delivery of plasmid DNA (pDNA) to the lungs using the GALA peptide. The double-coated LNPs significantly improved transfection activity in the lungs, achieving high gene expression levels and lung-selective delivery. GALA/R8 modification and the double-coating design were essential for efficient gene expression in the lungs.

MOLECULAR PHARMACEUTICS (2021)

Add to Collection
Review Polymer Science

Polymer Nanoparticles and Nanomotors Modified by DNA/RNA Aptamers and Antibodies in Targeted Therapy of Cancer

Veronika Subjakova et al.

Summary: This article focuses on the use of polymer nanoparticles and nano/micromotors modified by antibodies and nucleic acid aptamers in cancer diagnosis and therapy. Various driving mechanisms are utilized for targeted drug delivery, showing great potential for personalized nanomedicine.

POLYMERS (2021)

Add to Collection
Review Pharmacology & Pharmacy

Overcoming barriers by local drug delivery with liposomes

S. G. Antimisiaris et al.

Summary: Localized or topical drug administration, in combination with nanoparticulate formulations like liposomes, can offer advantages such as prolonged retention of high drug loads, controlled release, reduced side effects, and increased protection from harsh environments. Targeted liposomal formulations may enhance these therapeutic advantages in drug delivery.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Cationic lipids for gene delivery: many players, one goal

Federica Ponti et al.

Summary: Lipid-based carriers are widely used as non-viral vectors for gene expression and gene silencing, due to their ease of synthesis and modification. While significant progress has been made in developing cationic lipids, further research is needed for more effective lipid vectors for gene transfection. This review emphasizes the importance of designing each constituent domain of cationic lipids and how it affects their performance.

CHEMISTRY AND PHYSICS OF LIPIDS (2021)

Add to Collection
Review Medicine, Research & Experimental

DNA vaccines against COVID-19: Perspectives and challenges

Marcelle Moura Silveira et al.

Summary: The urgent need for COVID-19 vaccines has led to a focus on DNA vaccines as a promising alternative due to their ability to elicit strong immune responses and production advantages. This review summarizes the current research and advancements of DNA vaccines against COVID-19, with a particular emphasis on progress in clinical trials.

LIFE SCIENCES (2021)

Add to Collection
Article Instruments & Instrumentation

Current approaches in lipid-based nanocarriers for oral drug delivery

Maria Plaza-Oliver et al.

Summary: Lipid-based nanocarriers have advantages like low toxicity and strong biocompatibility, making them ideal carriers for drugs with poor oral bioavailability. However, efficient oral drug delivery through these carriers is challenging due to multiple physicochemical barriers along the gastrointestinal tract. Rational design of nanocarriers can turn these limitations into opportunities, ultimately determining their future clinical success.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

Add to Collection
Review Pharmacology & Pharmacy

Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines

Basmah N. Aldosari et al.

Summary: RNA-based vaccines have gained increased interest for protection against infectious diseases and cancer immunotherapies. Lipid nanoparticles (LNPs) are being studied as efficient carriers for mRNA delivery due to their easy manufacturing processes, offering promising alternatives to conventional vaccine technologies.

PHARMACEUTICS (2021)

Add to Collection
Review Biotechnology & Applied Microbiology

Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles

Michele Schlich et al.

Summary: Ionizable lipid nanoparticles (LNPs) are the most advanced nano-delivery system for therapeutic nucleic acids, with the development of ionizable lipids playing a key role in their success. Overcoming challenges in RNA delivery, such as endosomal escape, is crucial for ensuring the therapeutic activity of RNA molecules. Understanding the mechanisms of endosomal escape and improving cytosolic delivery are important for developing future LNPs with enhanced nucleic acid delivery capabilities.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2021)

Add to Collection
Article Engineering, Biomedical

PEGylation of poly(amine-co-ester) polyplexes for tunable gene delivery

Molly K. Grun et al.

Summary: The study found that low concentrations of PACE-PEG can improve polyplex stability but also inhibit transfection efficiency. In vivo, the effect of PACE-PEG incorporation on transfection varied by delivery route, and excess PEGylation was detrimental to vehicle function.

BIOMATERIALS (2021)

Add to Collection
Review Infectious Diseases

The Development of mRNA Vaccines for Infectious Diseases: Recent Updates

Nitika et al.

Summary: mRNA-based vaccines have shown great potential in combating the COVID-19 pandemic, drawing attention to the development of vaccines for various infectious diseases and gaining approval for global health authorities.

INFECTION AND DRUG RESISTANCE (2021)

Add to Collection
Review Pharmacology & Pharmacy

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

Linde Schoenmaker et al.

Summary: The current mRNA-lipid nanoparticle COVID-19 vaccines require storage at low temperatures due to instability. Improving mRNA nucleotide composition, understanding the impact of mRNA environment within LNPs, and exploring drying techniques can enhance vaccine stability.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Add to Collection
Review Cell Biology

Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis

Sophie Gohy et al.

Summary: The respiratory epithelium serves as the first line of defense against inhaled pathogens in cystic fibrosis patients, with mucosal alterations and local immunity linked to immunoglobulin A playing crucial roles in inflammation and bacterial overgrowth within the airways.

CELLS (2021)

Add to Collection
Review Biochemistry & Molecular Biology

RNA-based therapies: A cog in the wheel of lung cancer defense

Parvez Khan et al.

Summary: Lung cancer, comprising mainly NSCLC and SCLC, remains a challenging disease with low survival rates, but RNA-mediated gene inhibition technologies hold promise for innovative therapeutic approaches.

MOLECULAR CANCER (2021)

Add to Collection
Article Crystallography

Dopamine-Grafted Hyaluronic Acid Coated Hyperbranched Poly(β-Amino Esters)/DNA Nano-Complexes for Enhanced Gene Delivery and Biosafety

Man Guo et al.

Summary: Gene therapy has attracted attention for the treatment of genetic diseases, and the development of gene delivery vectors is crucial for in vivo applications. A dopamine-grafted hyaluronic acid was used to modify gene vectors, enhancing gene delivery and biosafety. Optimizing the dopamine grafting ratio resulted in a nano-system with excellent transfection efficiency and promising applications.

CRYSTALS (2021)

Add to Collection
Review Pharmacology & Pharmacy

Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers

Julian D. Torres-Vanegas et al.

Summary: This review highlights the potential of gene therapy in addressing genetic diseases and the use of non-viral systems, specifically nanoparticles, for efficient delivery of therapeutic cargoes. Researchers have focused on overcoming biological barriers and enhancing cellular internalization to achieve successful cargo delivery. The diversity of nanocarriers and recent advances in strategies for cargo delivery are discussed to improve the effectiveness of gene therapy.

PHARMACEUTICS (2021)

Add to Collection
Review Engineering, Biomedical

From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases

Emily H. Pilkington et al.

Summary: Vaccination is crucial in fighting infectious diseases, and mRNA vaccines formulated with lipid nanoparticles offer a faster and safer alternative for vaccination. Breakthroughs in mRNA-LNP vaccine development have shown promising results in combating infectious diseases and are currently being applied in clinical trials.

ACTA BIOMATERIALIA (2021)

Add to Collection
Review Biochemistry & Molecular Biology

How Far Are Non-Viral Vectors to Come of Age and Reach Clinical Translation in Gene Therapy?

Myriam Sainz-Ramos et al.

Summary: This review highlights the critical importance of efficient delivery of genetic material into cells for translating gene therapy into clinical practice, with a focus on non-viral vector systems as a promising alternative to virus-based gene delivery. The challenges and potential strategies for clinical application of non-viral vectors in mainstream medicine, including efficiency, biocompatibility, and long-lasting effect, are discussed in order to promote safe and efficient non-viral gene delivery systems for clinical applications in the gene therapy field.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Peptide-Assisted Nucleic Acid Delivery Systems on the Rise

Shabnam Tarvirdipour et al.

Summary: Peptides play a crucial role in advancing gene delivery systems in nanomedicine. They assist in ferrying nucleic acids to their target sites efficiently and overcoming membrane barriers encountered on the way.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Basic Methods for Preparation of Liposomes and Studying Their Interactions with Different Compounds, with the Emphasis on Polyphenols

Luka Sturm et al.

Summary: Studying the interactions between lipid membranes and bioactive molecules is crucial for understanding their effects on lipid bilayers, which can be utilized for inhibiting bacteria, cancer cells, eliminating viruses, or maintaining healthy cells. Liposomes, as model lipid membranes, provide a basic and stable platform for investigating the effects of bioactive compounds on lipid membranes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

Add to Collection
Review Pharmacology & Pharmacy

Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines

Yi Guo et al.

Summary: Pulmonary administration route is widely used for treating local lung diseases and systemic diseases, and extending the exposure of inhaled medicines in the lungs can improve therapeutic outcomes and patient compliance.

ACTA PHARMACEUTICA SINICA B (2021)

Add to Collection
Review Pharmacology & Pharmacy

Applications and developments of gene therapy drug delivery systems for genetic diseases

Xiuhua Pan et al.

Summary: Genetic diseases pose a serious threat to human health and gene therapy drugs show great potential in treating them; while viral vectors are commonly used for gene therapy delivery, novel nanocarriers are gradually replacing them for superior performance.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Add to Collection
Review Pharmacology & Pharmacy

Cell-Penetrating Peptides and Transportan

Ulo Langel

Summary: In the past 25-30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. Research in the author's own laboratories has led to the development of multiple CPPs, paving the way for delivering bio-functional materials.

PHARMACEUTICS (2021)

Add to Collection
Article Engineering, Biomedical

Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs

Melissa P. Lokugamage et al.

Summary: This study optimized the design of lipid nanoparticles for the efficient delivery of therapeutic mRNA to the lungs via nebulization, resulting in protection of mice from a lethal challenge of H1N1 influenza A virus and more efficient delivery of mRNA compared to LNPs previously optimized for systemic delivery. The cluster approach to LNP design may facilitate the optimization of LNPs for other administration routes and therapeutics.

NATURE BIOMEDICAL ENGINEERING (2021)

Add to Collection
Review Biotechnology & Applied Microbiology

Physical and mechanical cues affecting biomaterial-mediated plasmid DNA delivery: insights into non-viral delivery systems

Valeria Graceffa

Summary: The review explores the use of biomaterials in gene delivery, focusing on DNA internalization, cytoplasmic transport, 3D scaffolds, and surface-mediated gene delivery. The choice and design of biomaterials can impact DNA release and transgene expression, highlighting the importance of understanding these processes for novel gene delivery systems.

JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY (2021)

Add to Collection
Review Medicine, Research & Experimental

Pulmonary gene delivery-Realities and possibilities

Uday K. Baliga et al.

Summary: Delivery of genetic material to the lung remains a practical problem clinically, and is considered the major obstacle for gene therapy. There are currently four main strategies for in vivo gene delivery to the lung: viral vectors, liposomes, nanoparticles, and electroporation. Each of these vectors can be used for different gene delivery applications based on mechanisms of action, side-effects, and other factors.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

Add to Collection
Review Cell Biology

Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells-overview and perspectives

Xuefei Cao et al.

Summary: The lung is directly exposed to external environment, making it susceptible to airborne substances. Development of reliable in vitro models has shown promise in supplementing or replacing in vivo animal models for studying respiratory toxicants and pathogens.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2021)

Add to Collection
Review Nanoscience & Nanotechnology

A review on RNAi therapy for NSCLC: Opportunities and challenges

Vignesh Kumar et al.

Summary: Non-small cell lung cancer (NSCLC) is a major cause of cancer-related deaths worldwide, with treatment focusing on targeting oncogenes, but the efficacy is often limited by drug resistance. Development of more effective treatment strategies is crucial.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2021)

Add to Collection
Review Nanoscience & Nanotechnology

Toxicological assessment of nanoparticle interactions with the pulmonary system

Nashwa M. Osman et al.

NANOTOXICOLOGY (2020)

Add to Collection
Review Pharmacology & Pharmacy

Physicochemical properties affecting the fate of nanoparticles in pulmonary drug delivery

Qiaoyu Liu et al.

DRUG DISCOVERY TODAY (2020)

Add to Collection
Article Chemistry, Medicinal

Delivery of pDNA to lung epithelial cells using PLGA nanoparticles formulated with a cell-penetrating peptide: understanding the intracellular fate

Larissa Gomes dos Reis et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2020)

Add to Collection
Review Chemistry, Medicinal

Solid lipid nanoparticles: a review on recent perspectives and patents

Rishi Paliwal et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2020)

Add to Collection
Article Immunology

Mucosal vaccines: Strategies and challenges

Miao Li et al.

IMMUNOLOGY LETTERS (2020)

Add to Collection
Article Pharmacology & Pharmacy

Naked pDNA/hyaluronic acid powder shows excellent long-term storage stability and gene expression in murine lungs

Takaaki Ito et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Add to Collection
Article Pharmacology & Pharmacy

MRI/Photoluminescence Dual-Modal Imaging Magnetic PLGA Nanocapsules for Theranostics

Yajie Zhang et al.

PHARMACEUTICS (2020)

Add to Collection
Article Pharmacology & Pharmacy

Anti-Metastatic Effects on Melanoma via Intravenous Administration of Anti-NF-κB siRNA Complexed with Functional Peptide-Modified Nano-Micelles

Hisako Ibaraki et al.

PHARMACEUTICS (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Engineering Caveolae-Targeted Lipid Nanoparticles To Deliver mRNA to the Lungs

Qing Li et al.

ACS CHEMICAL BIOLOGY (2020)

Add to Collection
Review Medicine, Research & Experimental

RNA-based pharmacotherapy for tumors: From bench to clinic and back

Xiangping Liang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection
Review Respiratory System

Smoking-associated interstitial lung disease: update and review

Yaser T. Dawod et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2020)

Add to Collection
Article Nanoscience & Nanotechnology

Surface-Functionalized PEGylated Nanoparticles Deliver Messenger RNA to Pulmonary Immune Cells

Xiyu Ke et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Add to Collection
Review Pharmacology & Pharmacy

Liposomes: Advancements and innovation in the manufacturing process

Sanket Shah et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Add to Collection
Review Pharmacology & Pharmacy

Lipid nanoparticles for nucleic acid delivery: Current perspectives

Eleni Samaridou et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Add to Collection
Review Pharmacology & Pharmacy

Polymeric vehicles for nucleic acid delivery

Alexandra S. Piotrowski-Daspit et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Add to Collection
Review Pharmacology & Pharmacy

Recent advances in siRNA delivery mediated by lipid-based nanoparticles

Sei Yonezawa et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Add to Collection
Review Pharmacology & Pharmacy

Inhaled Liposomal Antimicrobial Delivery in Lung Infections

Matteo Bassetti et al.

DRUGS (2020)

Add to Collection
Article Pharmacology & Pharmacy

Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-α siRNA with PAMAM dendrimers in a murine model

Adam Bohr et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

Add to Collection
Review Respiratory System

Nebulized Therapies in COPD: Past, Present, and the Future

Igor Z. Barjaktarevic et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2020)

Add to Collection
Article Pharmacology & Pharmacy

Developing spray-freeze-dried particles containing a hyaluronic acid-coated liposome-protamine-DNA complex for pulmonary inhalation

Kaori Fukushige et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Add to Collection
Review Chemistry, Multidisciplinary

COVID-19 Vaccine Frontrunners and Their Nanotechnology Design

Young Hun Chung et al.

ACS NANO (2020)

Add to Collection
Review Medicine, Research & Experimental

Molecular Pathology of Primary Non-small Cell Lung Cancer

David Ilan Suster et al.

ARCHIVES OF MEDICAL RESEARCH (2020)

Add to Collection
Article Pharmacology & Pharmacy

Charge reversible hyaluronic acid-modified dendrimer-based nanoparticles for siMDR-1 and doxorubicin co-delivery

Xin Zhang et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

Add to Collection
Article Biotechnology & Applied Microbiology

Treating Cystic Fibrosis with mRNA and CRISPR

Alejandro Da Silva Sanchez et al.

HUMAN GENE THERAPY (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Pharmacokinetics of inhaled nanotherapeutics for pulmonary delivery

Andrew M. Shen et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection
Article Chemistry, Multidisciplinary

In vivo gene delivery mediated by non-viral vectors for cancer therapy

Reza Mohammadinejad et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Mucin Biopolymers and Their Barrier Function at Airway Surfaces

Daniel Song et al.

LANGMUIR (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

Aleksandra Zielinska et al.

MOLECULES (2020)

Add to Collection
Review Pharmacology & Pharmacy

Inhaled RNA Therapy: From Promise to Reality

Michael Y. T. Chow et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

Add to Collection
Review Biotechnology & Applied Microbiology

Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review

You Xu et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

Add to Collection
Review Respiratory System

The Respiratory Risks of Ambient/Outdoor Air Pollution

Gary Adamkiewicz et al.

CLINICS IN CHEST MEDICINE (2020)

Add to Collection
Article Pharmacology & Pharmacy

Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics

Carla B. Roces et al.

PHARMACEUTICS (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Mechanism of Cell Penetration by Permeabilization of Late Endosomes: Interplay between a Multivalent TAT Peptide and Bis(monoacylglycero)phosphate

Dakota J. Brock et al.

CELL CHEMICAL BIOLOGY (2020)

Add to Collection
Review Chemistry, Medicinal

Subunit-based mucosal vaccine delivery systems for pulmonary delivery - Are they feasible?

Nirmal Marasini et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2019)

Add to Collection
Review Nanoscience & Nanotechnology

Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives

Anubhab Mukherjee et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Add to Collection
Review Biotechnology & Applied Microbiology

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Piotr S. Kowalski et al.

MOLECULAR THERAPY (2019)

Add to Collection
Article Biotechnology & Applied Microbiology

Transfection of pulmonary cells by stable pDNA-polycationic hybrid nanostructured particles

Diana P. Gaspar et al.

NANOMEDICINE (2019)

Add to Collection
Review Health Care Sciences & Services

Choosing the right inhaler for your asthma or COPD patient

Omar S. Usmani

THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2019)

Add to Collection
Review Pharmacology & Pharmacy

Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

Xuemei Ge et al.

PHARMACEUTICS (2019)

Add to Collection
Review Pharmacology & Pharmacy

Pressurized Metered Dose Inhaler Technology: Manufacturing

Ernest Vallorz et al.

AAPS PHARMSCITECH (2019)

Add to Collection
Review Pharmacology & Pharmacy

Strategies, design, and chemistry in siRNA delivery systems

Yizhou Dong et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

Add to Collection
Review Medicine, Research & Experimental

Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides

Keith Henry Moss et al.

MOLECULAR PHARMACEUTICS (2019)

Add to Collection
Review Chemistry, Multidisciplinary

Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors

Isabelle M. S. Degors et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Add to Collection
Review Pharmacology & Pharmacy

Recent advances in aerosol gene delivery systems using non-viral vectors for lung cancer therapy

Ah Young Lee et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

Add to Collection
Article Engineering, Biomedical

Mucopenetrating lipoplexes modified with PEG and hyaluronic acid for CD44-targeted local siRNA delivery to the lungs

Ana Paula Bernardes Almeida et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2019)

Add to Collection
Review Pharmacology & Pharmacy

Mucosal Vaccination via the Respiratory Tract

Marie Hellfritzsch et al.

PHARMACEUTICS (2019)

Add to Collection
Review Chemistry, Multidisciplinary

Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics

Jayesh A. Kulkarni et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Poly(β-amino ester)-based gene delivery systems: From discovery to therapeutic applications

Rosemeyre A. Cordeiro et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Kaushik Thanki et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Add to Collection
Article Pharmacology & Pharmacy

Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles

Tobias W. M. Keil et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

Add to Collection
Review Biochemistry & Molecular Biology

The Development of Functional Non-Viral Vectors for Gene Delivery

Suryaji Patil et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

Yingshan Qiu et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Add to Collection
Review Biochemical Research Methods

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery

Samuel A. Smith et al.

BIOCONJUGATE CHEMISTRY (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Delivery of pDNA Polyplexes to Bronchial and Alveolar Epithelial Cells Using a Mesh Nebulizer

Larissa Gomes dos Reis et al.

PHARMACEUTICAL RESEARCH (2019)

Add to Collection
Review Pharmacology & Pharmacy

Nanocarriers in effective pulmonary delivery of siRNA: current approaches and challenges

Denish Bardoliwala et al.

THERAPEUTIC DELIVERY (2019)

Add to Collection
Article Medicine, Research & Experimental

Strategy to enhance lung cancer treatment by five essential elements: inhalation delivery, nanotechnology, tumor-receptor targeting, chemo- and gene therapy

Olga B. Garbuzenko et al.

THERANOSTICS (2019)

Add to Collection
Review Pharmacology & Pharmacy

PEGylation for enhancing nanoparticle diffusion in mucus

Justin T. Huckaby et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Add to Collection
Article Chemistry, Physical

A review on cationic lipids with different linkers for gene delivery

Defu Zhi et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2018)

Add to Collection
Review Pharmacology & Pharmacy

The proton sponge hypothesis: Fable or fact?

Lotte M. P. Vermeulen et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

Add to Collection
Article Respiratory System

Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of siRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier

Ivana d'Angelo et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2018)

Add to Collection
Article Chemistry, Multidisciplinary

PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy

Gizem Osman et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Add to Collection
Review Chemistry, Multidisciplinary

Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates

Hadeer M. Abdelaziz et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Add to Collection
Review Chemistry, Multidisciplinary

Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system

Gangliang Huang et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Spray-Dried Nanoparticle-in-Microparticle Delivery Systems (NiMDS) for Gene Delivery, Comprising Polyethylenimine (PEI)-Based Nanoparticles in a Poly(Vinyl Alcohol) Matrix

Jan Schulze et al.

SMALL (2018)

Add to Collection
Article Pharmacology & Pharmacy

Dosimetry of inhaled elongate mineral particles in the respiratory tract: The impact of shape factor

Bahman Asgharian et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Add to Collection
Article Environmental Sciences

Towards the Identification of an In Vitro Tool for Assessing the Biological Behavior of Aerosol Supplied Nanomaterials

Luisana Di Cristo et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

Add to Collection
Article Pharmacology & Pharmacy

Dosing considerations for inhaled biologics

Silvia Ferrati et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Add to Collection
Review Pharmacology & Pharmacy

Nucleic Acid-Based Therapeutics for Pulmonary Diseases

Jing Chen et al.

AAPS PHARMSCITECH (2018)

Add to Collection
Review Biochemistry & Molecular Biology

Progress in biopharmaceutical development

Malgorzata Kesik-Brodacka

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2018)

Add to Collection
Article Pharmacology & Pharmacy

Inhaled gene delivery: a formulation and delivery approach

Larissa Gomes dos Reis et al.

EXPERT OPINION ON DRUG DELIVERY (2017)

Add to Collection
Article Cell Biology

Cilia and Mucociliary Clearance

Ximena M. Bustamante-Marin et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

Add to Collection
Article Pharmacology & Pharmacy

Inhalable siRNA-loaded nano-embedded microparticles engineered using microfluidics and spray drying

Monica Agnoletti et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

Add to Collection
Review Biochemistry & Molecular Biology

Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

S. Guan et al.

GENE THERAPY (2017)

Add to Collection
Article Pharmacology & Pharmacy

PEGylated composite nanoparticles of PLGA and polyethylenimine for safe and efficient delivery of pDNA to lungs

Atul Kolte et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Add to Collection
Article Pharmacology & Pharmacy

TPP-dendrimer nanocarriers for siRNA delivery to the pulmonary epithelium and their dry powder and metered-dose inhaler formulations

Elizabeth Bielski et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Add to Collection
Article Engineering, Biomedical

Scalable preparation of poly(ethyleneglycol)-grafted siRNA-loaded lipid nanoparticles using a commercially available fluidic device and tangential flow filtration

Yu Sakurai et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2017)

Add to Collection
Article Chemistry, Medicinal

PEGylation of the GALA Peptide Enhances the Lung-Targeting Activity of Nanocarriers That Contain Encapsulated siRNA

Sarochin Santiwarangkool et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

Add to Collection
Article Medicine, Research & Experimental

From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery

Yingshan Qiu et al.

MOLECULAR PHARMACEUTICS (2017)

Add to Collection
Article Biotechnology & Applied Microbiology

Lipid Nanoparticle Systems for Enabling Gene Therapies

Pieter R. Cullis et al.

MOLECULAR THERAPY (2017)

Add to Collection
Article Multidisciplinary Sciences

Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis

Maria D. I. Manunta et al.

SCIENTIFIC REPORTS (2017)

Add to Collection
Article Engineering, Biomedical

Human airway organoid engineering as a step toward lung regeneration and disease modeling

Qi Tan et al.

BIOMATERIALS (2017)

Add to Collection
Review Pharmacology & Pharmacy

Functional peptides for siRNA delivery

Wanyi Tai et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Add to Collection
Review Nanoscience & Nanotechnology

Polymeric nanoparticles: the future of nanomedicine

Brittany L. Banik et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2016)

Add to Collection
Review Pharmacology & Pharmacy

The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery

Xinwei Cheng et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Virus-Inspired Polymer for Efficient In Vitro and In Vivo Gene Delivery

Yilong Cheng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Add to Collection
Article Pharmacology & Pharmacy

Applications of lipid nanoparticles in gene therapy

Ana del Pozo-Rodriguez et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2016)

Add to Collection
Review Biotechnology & Applied Microbiology

Recent advances on biocompatible and biodegradable nanoparticles as gene carriers

Ahad Mokhtarzadeh et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2016)

Add to Collection
Article Pharmacology & Pharmacy

Hyaluronic acid-conjugated lipoplexes for targeted delivery of siRNA in a murine metastatic lung cancer model

Thais Leite Nascimento et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

Add to Collection
Review Chemistry, Multidisciplinary

Pulmonary administration of small interfering RNA: The route to go?

M. J. R. Ruigrok et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Mucosal vaccine delivery: Current state and a pediatric perspective

Akhilesh Kumar Shakya et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Add to Collection
Review Chemistry, Multidisciplinary

Barriers to inhaled gene therapy of obstructive lung diseases: A review

Namho Kim et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Add to Collection
Review Pharmacology & Pharmacy

Microfluidics: a transformational tool for nanomedicine development and production

Shyam Garg et al.

JOURNAL OF DRUG TARGETING (2016)

Add to Collection
Review Engineering, Chemical

Aerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery Systems

Susanne R. Youngren-Ortiz et al.

KONA POWDER AND PARTICLE JOURNAL (2016)

Add to Collection
Review Pharmacology & Pharmacy

Preclinical and clinical development of siRNA-based therapeutics

Gulnihal Ozcan et al.

ADVANCED DRUG DELIVERY REVIEWS (2015)

Add to Collection
Article Pharmacology & Pharmacy

Lipid-Based Nanocarriers for RNA Delivery

Hui Yi Xue et al.

CURRENT PHARMACEUTICAL DESIGN (2015)

Add to Collection
Review Pharmacology & Pharmacy

Recent advances in controlled pulmonary drug delivery

Zhenglin Hang et al.

DRUG DISCOVERY TODAY (2015)

Add to Collection
Review Chemistry, Multidisciplinary

Solid lipid nanoparticles as nucleic acid delivery system: Properties and molecular mechanisms

Marcelo B. De Jesus et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Bio-inspired pulmonary surfactant-modified nanogels: A promising siRNA delivery system

Lynn De Backer et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Norbert Pardi et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection
Article Medicine, Research & Experimental

Inhalable Dry Powder Formulations of siRNA and pH-Responsive Peptides with Antiviral Activity Against H1N1 Influenza Virus

Wanling Liang et al.

MOLECULAR PHARMACEUTICS (2015)

Add to Collection
Review Nanoscience & Nanotechnology

Inhalable nanoparticulate powders for respiratory delivery

Priya Muralidharan et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

Add to Collection
Article Multidisciplinary Sciences

Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy

Panagiotis Mastorakos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Add to Collection
Article Nanoscience & Nanotechnology

Recent Progress in Liposome Production, Relevance to Drug Delivery and Nanomedicine

Rumiana Koynova et al.

RECENT PATENTS ON NANOTECHNOLOGY (2015)

Add to Collection
Review Pharmacology & Pharmacy

Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs

Jafar Ezzati Nazhad Dolatabadi et al.

ADVANCED PHARMACEUTICAL BULLETIN (2015)

Add to Collection
Article Engineering, Biomedical

Polymeric nanoparticles for pulmonary protein and DNA delivery

Jyothi U. Menon et al.

ACTA BIOMATERIALIA (2014)

Add to Collection
Review Pharmacology & Pharmacy

Emerging inhalation aerosol devices and strategies: Where are we headed?

Qi (Tony) Zhou et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

Add to Collection
Review Biotechnology & Applied Microbiology

Functional and biodegradable dendritic macromolecules with controlled architectures as nontoxic and efficient nanoscale gene vectors

Kui Luo et al.

BIOTECHNOLOGY ADVANCES (2014)

Add to Collection
Article Pharmacology & Pharmacy

Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids

Wanling Liang et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)

Add to Collection
Review Pharmacology & Pharmacy

Gene therapy and DNA delivery systems

D. Ibraheem et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

Add to Collection
Article Engineering, Biomedical

Spermine-alt-poly(ethylene glycol) polyspermine as a safe and efficient aerosol gene carrier for lung cancer therapy

You-Kyoung Kim et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2014)

Add to Collection
Article Chemistry, Multidisciplinary

Programmed packaging for gene delivery

M. Hyodo et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Add to Collection
Article Chemistry, Multidisciplinary

Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier

Jung Soo Suk et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Add to Collection
Review Chemistry, Multidisciplinary

Endosomal Escape: A Bottleneck in Intracellular Delivery

Harshad K. Shete et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2014)

Add to Collection
Article Medicine, Research & Experimental

Poly(amidoamine) Dendrimer Nanocarriers and Their Aerosol Formulations for siRNA Delivery to the Lung Epithelium

Denise S. Conti et al.

MOLECULAR PHARMACEUTICS (2014)

Add to Collection
Article Chemistry, Multidisciplinary

Lipid Envelope-Type Nanoparticle Incorporating a Multifunctional Peptide for Systemic siRNA Delivery to the Pulmonary Endothelium

Kenji Kusumoto et al.

ACS NANO (2013)

Add to Collection
Review Pharmacology & Pharmacy

Nanotechnology and pulmonary delivery to overcome resistance in infectious diseases

Fernando Andrade et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Add to Collection
Review Biochemistry & Molecular Biology

Aerosol generation using nanometer liposome suspensions for pulmonary drug delivery applications

Saptarshi Chattopadhyay

JOURNAL OF LIPOSOME RESEARCH (2013)

Add to Collection
Review Pharmacology & Pharmacy

Liposomal formulations for inhalation

David Cipolla et al.

THERAPEUTIC DELIVERY (2013)

Add to Collection
Review Pharmacology & Pharmacy

Mechanisms of absorption and elimination of drugs administered by inhalation

Mariam Ibrahim et al.

THERAPEUTIC DELIVERY (2013)

Add to Collection
Article Chemistry, Multidisciplinary

Lipid-Peptide Vesicle Nanoscale Hybrids for Triggered Drug Release by Mild Hyperthermia in Vitro and in Vivo

Zahraa S. Al-Ahmady et al.

ACS NANO (2012)

Add to Collection
Review Pharmacology & Pharmacy

Pulmonary delivery of therapeutic siRNA

Jenny Ka-Wing Lam et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Add to Collection
Article Engineering, Biomedical

Self-assembly nanomicelles based on cationic mPEG-PLA-b-Polyarginine(R15) triblock copolymer for siRNA delivery

Zhi-Xia Zhao et al.

BIOMATERIALS (2012)

Add to Collection
Article Pharmacology & Pharmacy

Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic

Anu Puri et al.

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS (2012)

Add to Collection
Article Pharmacology & Pharmacy

Impact of lyoprotectants for the stabilization of biodegradable nanoparticles on the performance of air-jet, ultrasonic, and vibrating-mesh nebulizers

Moritz Beck-Broichsitter et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2012)

Add to Collection
Review Pharmacology & Pharmacy

Lipid-based carriers: manufacturing and applications for pulmonary route

Chiraz Jaafar-Maalej et al.

EXPERT OPINION ON DRUG DELIVERY (2012)

Add to Collection
Review Biochemistry & Molecular Biology

Vectors for Inhaled Gene Therapy in Lung Cancer. Application for Nano Oncology and Safety of Bio Nanotechnology

Paul Zarogouldis et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

Add to Collection
Review Chemistry, Multidisciplinary

Controlled pulmonary drug and gene delivery using polymeric nano-carriers

Moritz Beck-Broichsitter et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Add to Collection
Article Chemistry, Multidisciplinary

An inhalable β2-adrenoceptor ligand-directed guanidinylated chitosan carrier for targeted delivery of siRNA to lung

Yongfeng Luo et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Add to Collection
Article Chemistry, Multidisciplinary

Propellant-based inhalers for the non-invasive delivery of genes via oral inhalation

Denise S. Conti et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Add to Collection
Article Chemistry, Multidisciplinary

Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery

Rachel J. Fields et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Add to Collection
Article Chemistry, Multidisciplinary

Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA

Ditte Krohn Jensen et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Add to Collection
Review Pharmacology & Pharmacy

Engineered PLGA nano- and micro-carriers for pulmonary delivery: challenges and promises

Francesca Ungaro et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2012)

Add to Collection
Article Biotechnology & Applied Microbiology

PEGylated Polyplex With Optimized PEG Shielding Enhances Gene Introduction in Lungs by Minimizing Inflammatory Responses

Satoshi Uchida et al.

MOLECULAR THERAPY (2012)

Add to Collection
Article Multidisciplinary Sciences

Correction: The Interplay of Lung Surfactant Proteins and Lipids Assimilates the Macrophage Clearance of Nanoparticles

Christian A. Ruge et al.

PLoS One (2012)

Add to Collection
Article Virology

The mucosal immune system of the respiratory tract

Shintaro Sato et al.

CURRENT OPINION IN VIROLOGY (2012)

Add to Collection
Article Pharmacology & Pharmacy

In vivo transfection study of chitosan-DNA-FAP-B nanoparticles as a new non viral vector for gene delivery to the lung

Z. Mohammadi et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

Add to Collection
Article Chemistry, Multidisciplinary

Dry powder aerosols of polyethylenimine (PEI)-based gene vectors mediate efficient gene delivery to the lung

Corinna Pfeifer et al.

JOURNAL OF CONTROLLED RELEASE (2011)

Add to Collection
Article Chemistry, Medicinal

A Technical Feasibility Study of Dornase Alfa Delivery with eFlow (R) Vibrating Membrane Nebulizers: Aerosol Characteristics and Physicochemical Stability

Thomas Scherer et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

Add to Collection
Article Nanoscience & Nanotechnology

A novel cationic liposome formulation for efficient gene delivery via a pulmonary route

Peng Li et al.

NANOTECHNOLOGY (2011)

Add to Collection
Review Pharmacology & Pharmacy

Chitosan-based formulations for delivery of DNA and siRNA

Shirui Mao et al.

ADVANCED DRUG DELIVERY REVIEWS (2010)

Add to Collection
Article Pharmacology & Pharmacy

A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung

M. Nassimi et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2010)

Add to Collection
Article Pharmacology & Pharmacy

Vectors for pulmonary gene therapy

Johannes Geiger et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

Add to Collection
Article Chemistry, Multidisciplinary

Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation

Ditte Marie Krohn Jensen et al.

JOURNAL OF CONTROLLED RELEASE (2010)

Add to Collection
Article Chemistry, Multidisciplinary

Mannan-Modified Solid Lipid Nanoparticles for Targeted Gene Delivery to Alveolar Macrophages

Wangyang Yu et al.

PHARMACEUTICAL RESEARCH (2010)

Add to Collection
Article Chemistry, Multidisciplinary

Nanocomposites of lung surfactant and biodegradable cationic nanoparticles improve transfection efficiency to lung cells

Juliane Nguyen et al.

JOURNAL OF CONTROLLED RELEASE (2009)

Add to Collection
Review Immunology

Pulmonary vaccine delivery

Dongmei Lu et al.

EXPERT REVIEW OF VACCINES (2007)

Add to Collection
Article Biochemical Research Methods

Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes

Shirui Mao et al.

BIOCONJUGATE CHEMISTRY (2006)

Add to Collection
Article Chemistry, Medicinal

A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells

Naoki Kanayama et al.

CHEMMEDCHEM (2006)

Add to Collection
Article Biochemistry & Molecular Biology

Cationic amphipathic histidine-rich peptides for gene delivery

Antoine Kichler et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2006)

Add to Collection
Review Pharmacology & Pharmacy

GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery

WJ Li et al.

ADVANCED DRUG DELIVERY REVIEWS (2004)

Add to Collection
Article Pharmacology & Pharmacy

PLGA-PEI nanoparticles for gene delivery to pulmonary epithelium

M Bivas-Benita et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2004)

Add to Collection
Review Chemistry, Multidisciplinary

Cationic compounds used in lipoplexes and polyplexes for gene delivery

SB Zhang et al.

JOURNAL OF CONTROLLED RELEASE (2004)

Add to Collection
Article Biochemical Research Methods

Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications

B Dalby et al.

METHODS (2004)

Add to Collection
Review Biochemistry & Molecular Biology

Cationic lipids for transfection

C Nicolazzi et al.

CURRENT MEDICINAL CHEMISTRY (2003)

Add to Collection
Review Biochemistry & Molecular Biology

Cationic liposomes for gene delivery:: From biophysics to biological applications

MCP de Lima et al.

CURRENT MEDICINAL CHEMISTRY (2003)

Add to Collection
Article Cardiac & Cardiovascular Systems

Fundamentals of pulmonary drug delivery

DA Groneberg et al.

RESPIRATORY MEDICINE (2003)

Add to Collection
Review Pharmacology & Pharmacy

Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications

NR Labiris et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2003)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.