☆ 4.8 Review

Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease

JOURNAL OF CONTROLLED RELEASE (2023)

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Debaryomyces is enriched in Crohn's disease intestinal tissue and impairs healing in mice

Umang Jain et al.

Summary: The study revealed that Debaryomyces hansenii fungus inhabits incompletely healed intestinal wounds of mice and inflamed mucosal tissues of CD patients, impairing colonic healing. Mechanistically, D. hansenii affects mucosal healing through the myeloid cell-specific type 1 interferon-CCL5 axis.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

Pengchao Zhao et al.

Summary: The authors have developed a bio-adhesive liquid coacervate coating that can act as a flowable drug carrier in the intestinal tract, mediating sustained release of drugs and enhancing therapeutic efficacy. This system shows significant stability, forming a physically adhesive coating on a large area of the intestinal tract for extended drug release.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

Polycatechol Mediated Small Interfering RNA Delivery for the Treatment of Ulcerative Colitis

Qianqian Fan et al.

Summary: This study designed and synthesized a family of cationic polycatechols for siRNA delivery, which showed enhanced siRNA binding capability and influenced the delivery efficiency. The results demonstrate that these polycatechols could be developed as a promising class of siRNA delivery systems for gene therapy.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Engineering, Biomedical

Oral delivery of antioxidant enzymes for effective treatment of inflammatory disease

Zhiying Zeng et al.

Summary: The approach of encapsulating native antiinflammatory proteins in wind chimes like cyclodextrin (WCC) for oral protein delivery is effective in enhancing stability and delivery efficiency. The integration of SOD and CAT in WCC nanovehicles shows synergistic effects in inhibiting inflammatory response, as demonstrated in a mouse colitis model.

BIOMATERIALS (2021)

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Article Multidisciplinary Sciences

Orally deliverable strategy based on microalgal biomass for intestinal disease treatment

Danni Zhong et al.

Summary: The innovative strategy of oral drug delivery using a formulation based on Spirulina platensis loaded with curcumin shows promise for treating intestinal diseases. The formulation not only improves drug bioavailability but also demonstrates excellent antitumor and anti-inflammatory efficacy.

SCIENCE ADVANCES (2021)

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Article Pharmacology & Pharmacy

Novel polyurethane based particulate formulations of infliximab reduce inflammation in DSS induced murine model of colitis-A preliminary study

Ritesh M. Pabari et al.

Summary: Novel infliximab-loaded polyesterurethane and polyesterurethane-polyethylene glycol particulate formulations showed promising results in reducing inflammation in a murine model of colitis, indicating their therapeutic potential for inflammatory bowel disease. Further investigation in wider preclinical studies is warranted.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Instruments & Instrumentation

Inflammation-responsive delivery systems for the treatment of chronic inflammatory diseases

Zhengyu Deng et al.

Summary: Inflammation is a biological response of the immune system to protect organisms, but excessive inflammation is related to various chronic diseases. While there are many anti-inflammatory therapeutics available, clinical outcomes vary and adverse effects are common. Designing inflammation-specific drug delivery systems could be a promising solution to address these challenges.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Nanoscience & Nanotechnology

Genistein-Derived ROS-Responsive Nanoparticles Relieve Colitis by Regulating Mucosal Homeostasis

Wentao Fan et al.

Summary: GEN-NP2 effectively delivers GEN to inflammatory sites, protects it from rapid metabolism and elimination in the gastrointestinal tract, and alleviates colitis. This nanoparticle increases the expression of estrogen receptor beta (ERβ), reduces the expression of proinflammatory mediators, modulates the gut microbiota, and ultimately relieves colitis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Oral Core-Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy

Xiao Wang et al.

Summary: The study successfully loaded magnolol into core-shell zein-based nanoparticles with chondroitin sulfate coating and embedded them into hydrogel microspheres, forming a system named Mag@CS-Zein NPsinMPs. This drug delivery system exhibited good macrophage-targeting and sustained drug release capabilities.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Pharmacology & Pharmacy

Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases

Menghang Zu et al.

Summary: The incidence of inflammatory bowel disease (IBD) is increasing worldwide, and natural active small molecules (NASMs) have shown potential in preventing and alleviating IBD. With the development of nanotechnology, polymeric nanoparticles (NPs) offer a promising platform to encapsulate versatile NASMs, enhancing their stability and bioavailability for targeted delivery to tissues or cells in IBD treatment.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Oligoethyleneimine-Conjugated Hyaluronic Acid Modulates Inflammatory Responses and Enhances Therapeutic Efficacy for Ulcerative Colitis

Akihiro Nishiguchi et al.

Summary: The study reports the discovery of a compound, bOEI, which has both anti-inflammatory properties and biocompatibility. It suppresses inflammatory responses by scavenging reactive oxygen species and inhibiting nuclear factor kappa-B, and its conjugate with hyaluronic acid enhances anti-inflammatory functions. In a murine ulcerative colitis model, this polyamine-conjugated biopolymer shows therapeutic potential by suppressing pro-inflammatory cytokine production.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Entrapment of Macrophage-Target Nanoparticles by Yeast Microparticles for Rhein Delivery in Ulcerative Colitis Treatment

Qiyan Chen et al.

Summary: The study developed an advanced drug delivery system for ulcerative colitis targeting the inflammed colon, showing promising results in terms of stability, drug release ability, and anti-inflammatory effects. The system has the potential to be a highly effective oral therapy for UC.

BIOMACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Broad-Spectrum Reactive Oxygen Species Scavenging and Activated Macrophage-Targeting Microparticles Ameliorate Inflammatory Bowel Disease

Jiawei Li et al.

Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease with excessively high levels of reactive oxygen species (ROS) in the colon. Fabricating broad-spectrum ROS scavenging and activated macrophage-targeting microparticles (MPs) can effectively treat IBD by reducing inflammation and targeting activated macrophages.

BIOMACROMOLECULES (2021)

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Article Chemistry, Applied

Calcium pectinate and hyaluronic acid modified lactoferrin nanoparticles loaded rhein with dual-targeting for ulcerative colitis treatment

Ruifeng Luo et al.

Summary: This study combined dual-targeting oral nano delivery strategy to apply Rhein for the treatment of ulcerative colitis, demonstrating its dual-bioresponsive effects in promoting colonic repair and inhibiting inflammatory reactions. Experimental results showed that CP/HA/RH-NPs significantly alleviated inflammation by inhibiting the TLR4/MyD88/NF-κB signaling pathway and accelerating colonic healing.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Multidisciplinary

Colon-Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora

Hua Liu et al.

Summary: This study developed a colon-targeted adhesive core-shell hydrogel microsphere that regulates the gut immune-microbiota microenvironment, significantly reduces pro-inflammatory cytokine secretion and alleviates colitis in a mouse model, while also optimizing gut flora composition.

ADVANCED SCIENCE (2021)

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Article Engineering, Biomedical

Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel

Kai Han et al.

Summary: Modulating the gut microbiome with orally administered gel can induce systemic antitumour immunity and enhance the activity of immune checkpoint inhibitors in murine tumour models. This method shows promise for treating pathologies associated with dysregulated gut microbiome.

NATURE BIOMEDICAL ENGINEERING (2021)

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Article Biochemistry & Molecular Biology

Butyrylated starch protects mice from DSS-induced colitis: combined effects of butyrate release and prebiotic supply

Lingjin Li et al.

Summary: Utilizing butyrylated starch for specific delivery of butyrate to the colon showed promising therapeutic effects on colitis by increasing butyrate and total short-chain fatty acid contents, suppressing DSS-induced colitis, and alleviating colonic inflammation. This strategy provides an effective approach for the assistant therapy of colitis through the combined effects of specific butyrate release in the colon and extra supply of fermentable substrates for gut microbiota.

FOOD & FUNCTION (2021)

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Article Biochemistry & Molecular Biology

Jellyfish skin polysaccharides enhance intestinal barrier function and modulate the gut microbiota in mice with DSS-induced colitis

Yu Cao et al.

Summary: The study showed that JSP supplementation alleviated symptoms of colitis, increased colon length, protected goblet cells, and improved intestinal epithelial integrity and permeability in mice.

FOOD & FUNCTION (2021)

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Article Biochemistry & Molecular Biology

Oat β-glucan alleviates DSS-induced colitis via regulating gut microbiota metabolism in mice

Junying Bai et al.

Summary: Our study found that oat beta-glucan could ameliorate DSS-induced colitis in mice by regulating gut-derived short-chain fatty acids (SCFAs) and microbial metabolic biomarkers. Oat beta-glucan may be an effective nutritional intervention strategy towards targeting gut microbiota metabolism for ameliorating colitis.

FOOD & FUNCTION (2021)

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Article Chemistry, Multidisciplinary

One-step prepared nano-in-micro microcapsule delivery vehicle with sequential burst-sustained drug release for the targeted treatment of inflammatory bowel disease

Jingjing Jiang et al.

Summary: Orally targeted drug delivery using a pH-responsive nano-in-micro composite is effective for treating inflammatory bowel disease (IBD). This drug delivery system allows for sequential burst-sustained drug release under colonic pH, achieving high drug concentration and quick reduction of inflammation. The success of this model demonstrates its potential for IBD therapy.

MATERIALS CHEMISTRY FRONTIERS (2021)

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Article Materials Science, Biomaterials

Thermosensitive polymer hydrogel as a physical shield on colonic mucosa for colitis treatment

Zhaoyuan Guo et al.

Summary: The study explores an injectable thermosensitive copolymer hydrogel as a topical formulation for the treatment of inflammatory bowel disease, demonstrating its feasibility in ulcerative colitis treatment by protecting ulcer sites and serving as a drug reservoir for sustained release.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Nanoscience & Nanotechnology

Polyvinyl Butyrate Nanoparticles as Butyrate Donors for Colitis Treatment

Yunmei Mu et al.

Summary: Polyvinyl butyrate (PVBu) nanoparticles (NPs) are proposed as butyrate donors for colitis treatment, showing suppressed inflammatory activation of macrophages in vitro and therapeutic effect on a colitis mouse model, especially when incorporating vitamin D3. PVBu NPs are a promising therapeutic for IBD treatment as both a butyrate donor and carrier for hydrophobic drugs like vitamin D3.

ACS APPLIED BIO MATERIALS (2021)

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Article Materials Science, Biomaterials

Oral nanotherapeutics with enhanced mucus penetration and ROS-responsive drug release capacities for delivery of curcumin to colitis tissues

Yamei Huang et al.

Summary: Functionalized PLGA-based nanoparticles with pluronic F127 and co-encapsulated catalase (CAT) and curcumin (CUR) showed enhanced mucus penetration, improved cellular uptake by macrophages, and increased release rate of CUR in an H2O2-rich environment. They also exhibited stronger inhibition of pro-inflammatory cytokines secretion and better therapeutic outcomes for ulcerative colitis (UC) compared to other nanoparticles. These results suggest that these mucus-penetrating nanoparticles loaded with CAT and CUR can be utilized as effective nanotherapeutics for UC therapy.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Pharmacology & Pharmacy

One-Pot Synthesis of pH-Responsive Eudragit-Mesoporous Silica Nanocomposites Enable Colonic Delivery of Glucocorticoids for the Treatment of Inflammatory Bowel Disease

Zhi Qu et al.

Summary: The study proposes a smart drug delivery system using functionalized mesoporous silica nanoparticles and pH-responsive polymer to improve the release efficiency and reduce systemic side effects of oral glucocorticoids. Results show that this system can release drugs at colonic pH and demonstrate therapeutic efficacy in a mouse colitis model. Coated nanoparticles significantly decrease cytokine expression in the proximal colon, indicating colonic delivery effectiveness.

ADVANCED THERAPEUTICS (2021)

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Article Chemistry, Physical

Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis

Yonghyun Lee et al.

NATURE MATERIALS (2020)

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Article Pharmacology & Pharmacy

Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions

Heng Li et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Review Biochemistry & Molecular Biology

Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting

Serena Bertoni et al.

BIOPOLYMERS (2020)

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Article Chemistry, Multidisciplinary

Amyloid-Polyphenol Hybrid Nanofilaments Mitigate Colitis and Regulate Gut Microbial Dysbiosis

Bing Hu et al.

ACS NANO (2020)

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Article Microbiology

Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production

Edward C. Deehan et al.

CELL HOST & MICROBE (2020)

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Review Gastroenterology & Hepatology

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

Aonghus Lavelle et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Sudabeh Alatab et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Chemistry, Multidisciplinary

Nanoparticles Derived from the Natural Antioxidant Rosmarinic Acid Ameliorate Acute Inflammatory Bowel Disease

Chan Ho Chung et al.

ACS NANO (2020)

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Article Engineering, Biomedical

A Novel Strategy for Treating Inflammatory Bowel Disease by Targeting Delivery of Methotrexate through Glucan Particles

Ying Sun et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Ultrasmall Rhodium Nanozyme with RONS Scavenging and Photothermal Activities for Anti-Inflammation and Antitumor Theranostics of Colon Diseases

Zhaohua Miao et al.

NANO LETTERS (2020)

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Article Chemistry, Multidisciplinary

Dextran-Coated Cerium Oxide Nanoparticles: A Computed Tomography Contrast Agent for Imaging the Gastrointestinal Tract and Inflammatory Bowel Disease

Pratap C. Naha et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

On-Demand Bacterial Reactivation by Restraining within a Triggerable Nanocoating

Pingping Feng et al.

ADVANCED MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Curcumin Nanocrystal/pH-Responsive Polyelectrolyte Multilayer Core-Shell Nanoparticles for Inflammation-Targeted Alleviation of Ulcerative Colitis

Murtada A. Oshi et al.

BIOMACROMOLECULES (2020)

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Article Multidisciplinary Sciences

Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

Yufeng Liu et al.

SCIENCE ADVANCES (2020)

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Article Chemistry, Multidisciplinary

Natural -lipid nanoparticle-based therapeutic approach to deliver 6-shogaol and its metabolites M2 and M13 to the colon to treat ulcerative colitis

Chunhua Yang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Engineering, Biomedical

Colitis-targeted hybrid nanoparticles-in-microparticles system for the treatment of ulcerative colitis

Muhammad Naeem et al.

ACTA BIOMATERIALIA (2020)

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Article Chemistry, Multidisciplinary

An Orally Administered CeO2@Montmorillonite Nanozyme Targets Inflammation for Inflammatory Bowel Disease Therapy

Shengwc. Zhao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Biochemistry & Molecular Biology

Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer

Winnie Fong et al.

ONCOGENE (2020)

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Review Biochemistry & Molecular Biology

Natural proteins and polysaccharides in the development of micro/nano delivery systems for the treatment of inflammatory bowel disease

Brijesh M. Shah et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Chemistry, Multidisciplinary

Recent advances in colon drug delivery systems

Roberto Arevalo-Perez et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Applied

Genipin-crosslinked human serum albumin coating using a tannic acid layer for enhanced oral administration of curcumin in the treatment of ulcerative colitis

Ruifeng Luo et al.

FOOD CHEMISTRY (2020)

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Article Medicine, Research & Experimental

Oral delivery of anti-TNF antibody shielded by natural polyphenol-mediated supramolecular assembly for inflammatory bowel disease therapy

Xinyu Wang et al.

THERANOSTICS (2020)

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Review Pharmacology & Pharmacy

Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives

Niranjan G. Kotla et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Review Biochemistry & Molecular Biology

Hyaluronan in inflammatory bowel disease: Cross-linking inflammation and coagulation

Aaron C. Petrey et al.

MATRIX BIOLOGY (2019)

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Review Instruments & Instrumentation

Natural and synthetic polymer-based smart biomaterials for management of ulcerative colitis: a review of recent developments and future prospects

Muhammad Sohail et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2019)

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Review Medicine, General & Internal

Fecal microbiota transplantation: Review and update

Jiunn-Wei Wang et al.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2019)

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Review Chemistry, Multidisciplinary

Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

Yanyan Huang et al.

CHEMICAL REVIEWS (2019)

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Article Pharmacology & Pharmacy

Oral administration of colitis tissue-accumulating porous nanoparticles for ulcerative colitis therapy

Qiubing Chen et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Review Pharmacology & Pharmacy

Advances in orally-delivered pH-sensitive nanocarrier systems; an optimistic approach for the treatment of inflammatory bowel disease

Mahira Zeeshan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Engineering, Biomedical

Orally Delivered Antisense Oligodeoxyribonucleotides of TNF-α via Polysaccharide-Based Nanocomposites Targeting Intestinal Inflammation

Bingchao Duan et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Review Chemistry, Multidisciplinary

Reactive Oxygen Species (ROS)-Based Nanomedicine

Bowen Yang et al.

CHEMICAL REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Mesenchymal Stem Cell Capping on ECM-Anchored Caspase Inhibitor-Loaded PLGA Microspheres for Intraperitoneal Injection in DSS-Induced Murine Colitis

Shiva Pathak et al.

SMALL (2019)

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Article Nanoscience & Nanotechnology

Hollow Microcapsules with Ulcerative Colitis Therapeutic Effects Made of Multifunctional Turkish Galls Extraction

Xing Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Engineering, Biomedical

Multi-bioresponsive silk fibroin-based nanoparticles with on-demand cytoplasmic drug release capacity for CD44-targeted alleviation of ulcerative colitis

Shuangquan Gou et al.

BIOMATERIALS (2019)

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Article Biochemistry & Molecular Biology

Novel biodegradable pH-sensitive hydrogels: An efficient controlled release system to manage ulcerative colitis

Mudassir Abbasi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Pharmacology & Pharmacy

Mucus-penetrating polymeric nanoparticles for oral delivery of curcumin to inflamed colon tissue

Xin Zhou et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2019)

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Editorial Material Microbiology

The future of faecal transplants

Edward M. Giles et al.

NATURE REVIEWS MICROBIOLOGY (2019)

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Article Chemistry, Multidisciplinary

A Proresolving Peptide Nanotherapy for Site-Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota

Chenwen Li et al.

ADVANCED SCIENCE (2019)

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Article Chemistry, Physical

Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC)

Xin Xu et al.

NANO RESEARCH (2019)

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Article Chemistry, Multidisciplinary

A self-assembled, ROS-responsive Janus-prodrug for targeted therapy of inflammatory bowel disease

Shanshan Li et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Gastroenterology & Hepatology

Control and dysregulation of redox signalling in the gastrointestinal tract

Eric L. Campbell et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Chemistry, Multidisciplinary

A nanogel based oral gene delivery system targeting SUMOylation machinery to combat gut inflammation

Prabhu Srinivas Yavvari et al.

NANOSCALE (2019)

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Review Gastroenterology & Hepatology

Targeting S1P in Inflammatory Bowel Disease: New Avenues for Modulating Intestinal Leukocyte Migration

Silvio Danese et al.

JOURNAL OF CROHNS & COLITIS (2018)

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Article Chemistry, Physical

Gel-forming mucin interactome drives mucus viscoelasticity

Bastien Demouveaux et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2018)

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Article Chemistry, Applied

Redox-sensitive nanoparticles based on 4-aminothiophenol-carboxymethyl inulin conjugate for budesonide delivery in inflammatory bowel diseases

Qijuan Sun et al.

CARBOHYDRATE POLYMERS (2018)

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Article Microbiology

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

Bjoern O. Schroeder et al.

CELL HOST & MICROBE (2018)

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Article Chemistry, Physical

Rational Design of Polyphenol-Poloxamer Nanovesicles for Targeting Inflammatory Bowel Disease Therapy

Xinyu Wang et al.

CHEMISTRY OF MATERIALS (2018)

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Article Pharmacology & Pharmacy

New mesalamine polymeric conjugate for controlled release: Preparation, characterization and biodistribution study

Aina L. A. Cesar et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

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Article Gastroenterology & Hepatology

Nanoparticle-Based Oral Drug Delivery Systems Targeting the Colon for Treatment of Ulcerative Colitis

Mingzhen Zhang et al.

INFLAMMATORY BOWEL DISEASES (2018)

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Article Chemistry, Physical

Surface charge tunable nanoparticles for TNF-α siRNA oral delivery for treating ulcerative colitis

Shoaib Iqbal et al.

NANO RESEARCH (2018)

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Article Nanoscience & Nanotechnology

pH-triggered surface charge-reversal nanoparticles alleviate experimental murine colitis via selective accumulation in inflamed colon regions

Muhammad Naeem et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

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Review Nutrition & Dietetics

Butyrate: A Double-Edged Sword for Health?

Hu Liu et al.

ADVANCES IN NUTRITION (2018)

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Article Engineering, Biomedical

Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine

Wei Li et al.

BIOMATERIALS (2018)

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Article Engineering, Biomedical

Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease

Abhijit A. Date et al.

BIOMATERIALS (2018)

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Article Chemistry, Multidisciplinary

TNFα gene silencing mediated by orally targeted nanoparticles combined with interleukin-22 for synergistic combination therapy of ulcerative colitis

Bo Xiao et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Chemistry, Multidisciplinary

Site-directed non-covalent polymer-drug complexes for inflammatory bowel disease (IBD): Formulation development, characterization and pharmacological evaluation

Siddharth S. Kesharwani et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Chemistry, Multidisciplinary

Green Fabrication of Ovalbumin Nanoparticles as Natural Polyphenol Carriers for Ulcerative Colitis Therapy

Shuangquan Gou et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2018)

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Article Engineering, Biomedical

Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease

Shrey Kanvinde et al.

ACTA BIOMATERIALIA (2018)

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Article Chemistry, Multidisciplinary

pH and Reactive Oxygen Species-Sequential Responsive Nano-in-Micro Composite for Targeted Therapy of Inflammatory Bowel Disease

Serena Bertoni et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Gastroenterology & Hepatology

Prebiotic inulin-type fructans induce specific changes in the human gut microbiota

Doris Vandeputte et al.

GUT (2017)

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Article Pharmacology & Pharmacy

Co-delivery of zinc and 5-aminosalicylic acid from alginate/N-succinyl-chitosan blend microspheres for synergistic therapy of colitis

Haogang Duan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Pharmacology & Pharmacy

Development and characterization of anti-inflammatory activity of curcumin-loaded biodegradable microspheres with potential use in intestinal inflammatory disorders

E. Blanco-Garcia et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Biotechnology & Applied Microbiology

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

Bo Xiao et al.

MOLECULAR THERAPY (2017)

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Review Chemistry, Multidisciplinary

Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease

Sufeng Zhang et al.

NANO TODAY (2017)

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Article Biochemistry & Molecular Biology

Synergic modulation of the inflammatory state of macrophages utilizing anti-oxidant and phosphatidylserine-containing polymer-lipid hybrid nanoparticles

Md. Zahangir Hosain et al.

MEDCHEMCOMM (2017)

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Article Medicine, Research & Experimental

Dexamethasone-loaded Polymeric Nanoconstructs for Monitoring and Treating Inflammatory Bowel Disease

Aeju Lee et al.

THERANOSTICS (2017)

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Article Materials Science, Biomaterials

Oral delivery of curcumin via porous polymeric nanoparticles for effective ulcerative colitis therapy

Qiubing Chen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

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Article Microbiology

The gut mycobiome of the Human Microbiome Project healthy cohort

Andrea K. Nash et al.

MICROBIOME (2017)

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Article Biochemistry & Molecular Biology

Folate-Targeted Dendrimers Selectively Accumulate at Sites of Inflammation in Mouse Models of Ulcerative Colitis and Atherosclerosis

Scott Poh et al.

BIOMACROMOLECULES (2017)

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Review Chemistry, Applied

Alginate microparticles as oral colon drug delivery device: A review

Lissette Aguero et al.

CARBOHYDRATE POLYMERS (2017)

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Article Gastroenterology & Hepatology

Incidence and Prevalence of Crohn's Disease and Ulcerative Colitis in Olmsted County, Minnesota From 1970 Through 2010

Raina Shivashankar et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2017)

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Article Chemistry, Multidisciplinary

Bilirubin Nanoparticles as a Nanomedicine for Anti-inflammation Therapy

Yonghyun Lee et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Article Engineering, Biomedical

A superoxide dismutase/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease

Qixiong Zhang et al.

BIOMATERIALS (2016)

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Article Chemistry, Applied

Sulfated polysaccharide from the marine algae Hypnea musciformis inhibits TNBS-induced intestinal damage in rats

Tarcisio V. Brito et al.

CARBOHYDRATE POLYMERS (2016)

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Article Biophysics

Mucoadhesive microparticulates based on polysaccharide for target dual drug delivery of 5-aminosalicylic acid and curcumin to inflamed colon

Haogang Duan et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

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Article Chemistry, Multidisciplinary

Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse

Katharina Maisel et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Gastroenterology & Hepatology

The global burden of IBD: from 2015 to 2025

Gilaad G. Kaplan

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2015)

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Article Cell Biology

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease

Sufeng Zhang et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Article Multidisciplinary Sciences

An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment

Hyunjae Lee et al.

NATURE COMMUNICATIONS (2015)

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Article Chemistry, Multidisciplinary

Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease

Hongzhuan Yin et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Article Engineering, Biomedical

Galactosylated trimethyl chitosan-cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages

Jing Zhang et al.

BIOMATERIALS (2013)

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Article Engineering, Biomedical

Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy

Bo Xiao et al.

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