☆ 4.5 Review

The roles and mechanisms of circular RNAs related to mTOR in cancers

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

Related references

Note: Only part of the references are listed.

Correction Biochemistry & Molecular Biology

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb (vol 13, pg 1259, 2003)

Andrew R. Tee et al.

CURRENT BIOLOGY (2022)

Add to Collection

Review Pharmacology & Pharmacy

Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discovery

Raef Shams et al.

Summary: mTOR is a protein kinase involved in cell growth and proliferation, which can be assembled into mTORC1 and mTORC2 complexes with different functions. In cancer cells, mTOR is hyperactivated to adapt to stress conditions, leading to efforts in developing compounds to inhibit mTOR and disrupt cancer cell metabolism.

PHARMACOLOGY & THERAPEUTICS (2022)

Add to Collection

Article Oncology

Hsa_circ_0001666 promotes non-small cell lung cancer migration and invasion through miR-1184/miR-548I/AGO1 axis

Xueting Wang et al.

Summary: The dysregulation of circRNAs is crucial in cancer progression, with circ0001666 found to be highly expressed in NSCLC tissues and cell lines, correlated with tumor features, and promoting migration and invasion of NSCLC cells through a miR-1184/miR-548I/AGO1 axis.

MOLECULAR THERAPY-ONCOLYTICS (2022)

Add to Collection

Review Oncology

Circular RNAs and Drug Resistance in Genitourinary Cancers: A Literature Review

Gongwei Long et al.

Summary: This review focuses on the role of circular RNAs (circRNAs) in drug resistance in genitourinary tumors and summarizes the underlying mechanisms. It highlights the essential role of circRNAs in drug resistance development and points out potential future research directions. The potential clinical prospect of circRNAs in regulating tumor drug resistance is also discussed.

CANCERS (2022)

Add to Collection

Article Oncology

CircWHSC1 Promotes Breast Cancer Progression by Regulating the FASN/AMPK/mTOR Axis Through Sponging miR-195-5p

Qian Chen et al.

Summary: Studies have shown that circRNAs play a role in cancer progression. In this study, circWHSC1 was identified as a novel circRNA that accelerates ovarian cancer progression. The function of circWHSC1 in breast cancer was investigated, and it was found that circWHSC1 is up-regulated in breast cancer tissues and is associated with higher tumor stages, lymphatic metastasis, and worse survival of breast cancer patients. Functional experiments showed that circWHSC1 promotes breast cancer cell proliferation, migration, invasion, and tumor growth. Mechanistically, circWHSC1 functions as a competitive endogenous RNA by sponging miR-195-5p, which delays breast cancer progression. In addition, miR-195-5p regulates the expression of fatty acid synthase (FASN) and activates the AMPK/mTOR pathway. Inhibition of FASN or activation of the AMPK pathway reverses the oncogenic effects mediated by circWHSC1. Overall, circWHSC1 acts as an oncogene in breast cancer by modulating the miR-195-5p/FASN/AMPK/mTOR pathway.

FRONTIERS IN ONCOLOGY (2022)

Add to Collection

Article Oncology

The novel role of circular RNA ST3GAL6 on blocking gastric cancer malignant behaviours through autophagy regulated by the FOXP2/MET/mTOR axis

Penghui Xu et al.

Summary: In this study, it was found that circST3GAL6 was downregulated in gastric cancer and was associated with poor prognosis. Overexpression of circST3GAL6 inhibited malignant behaviors of gastric cancer cells, potentially through inducing apoptosis and autophagy. Furthermore, it was demonstrated that circST3GAL6 regulated gastric cancer through the miR-300/FOXP2 axis and regulated apoptosis and autophagy through FOXP2-mediated inhibition of the MET pathway.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

Add to Collection

Article Medical Laboratory Technology

Upregulation of hsa_circ_0000977 participates in esophageal squamous cancer progression by sponging miR-874-3p

Ni Li et al.

Summary: This study found that hsa_circ_0000977 is significantly upregulated in esophageal squamous cell carcinoma (ESCC) and has diagnostic value. The expression level of hsa_circ_0000977 is associated with tumor stage and lymph node involvement. High expression of hsa_circ_0000977 promotes tumor cell proliferation and migration, while inhibiting apoptosis.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Circular RNA UBAP2 facilitates the cisplatin resistance of triple-negative breast cancer via microRNA-300/anti-silencing function 1B histone chaperone/PI3K/AKT/mTOR axis

Leiming Wang et al.

Summary: circUBAP2 promotes cisplatin resistance in TNBC by upregulating ASF1B and activating PI3K/AKT/mTOR signaling.

BIOENGINEERED (2022)

Add to Collection

Article Cell Biology

Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling

Hongchang Li et al.

Aging-US (2021)

Add to Collection

Review Cell Biology

Opportunities and challenges of glioma organoids

Xiangdong Xu et al.

Summary: Glioma, the most common primary brain tumor with poor prognosis, requires an urgent platform to study its cell dynamics and develop effective treatments. Organoids, a 3D structure similar to human tissues, are considered the most suitable research platform for glioma research, overcoming the drawbacks of previous models and contributing to the diagnosis and treatment of glioma.

CELL COMMUNICATION AND SIGNALING (2021)

Add to Collection

Article Medical Laboratory Technology

circCORO1C promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing the expression of PD-L1 through NF-κB pathway

Fan Wu et al.

Summary: The study revealed that circCORO1C can activate the NF-kappa B signaling pathway, leading to increased P65 phosphorylation and upregulation of c-Myc and COX-2, resulting in increased PD-L1 expression which promotes the development of HCC.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma

Weipu Mao et al.

Summary: ciRS-7 is highly expressed in RCC and acts as a tumor promoter by regulating the miR-139-3p/TAGLN axis and activating the PI3K/AKT signaling pathway to promote RCC progression and metastasis. PBAE/si-ciRS-7 nanocomplexes can significantly inhibit RCC tumor progression and metastasis, representing a promising gene therapeutic strategy.

MOLECULAR CANCER (2021)

Add to Collection

Review Medicine, General & Internal

Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review

Leah H. Biller et al.

Summary: Colorectal cancer is the third most common cause of cancer mortality worldwide. For patients diagnosed with metastatic colorectal cancer, approximately 70% to 75% can survive beyond 1 year. Tailoring treatments based on the molecular and pathologic features of the tumor has shown to improve overall survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection

Review Medicine, General & Internal

New Horizons in the Treatment of Osteosarcoma

Paul S. Meltzer et al.

Summary: Osteosarcoma is a common malignant tumor that primarily affects individuals aged 10 to 30, and is usually treated with surgery and chemotherapy. While whole-genome sequencing can detect genetic alterations, it has not yet resulted in improved treatment outcomes.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection

Article Medicine, Research & Experimental

The depletion of Circ-PRKDC enhances autophagy and apoptosis in T-cell acute lymphoblastic leukemia via microRNA-653-5p/Reelin mediation of the PI3K/AKT/mTOR signaling pathway

Zhang Ling et al.

Summary: A study on the mechanisms of Circ-PRKDC and miR-653-5p/RELN axis in T-cell acute lymphoblastic leukemia (T-ALL) found that Circ-PRKDC acted as a sponge for miR-653-5p, which in turn targeted RELN, affecting cell proliferation, apoptosis, and autophagy. The interactions between Circ-PRKDC, miR-653-5p, and RELN disrupted the PI3K/AKT/mTOR signaling pathway, enhancing autophagy and apoptosis in T-ALL cells. These findings suggest potential therapeutic targets for T-ALL involving this specific RNA network.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

Fei Long et al.

Summary: Colorectal cancer involves abnormal expression of circRNAs, which act as oncogenes or tumor suppressors in regulating tumorigenesis, metastasis, and chemoradiation resistance. CircRNAs also serve as potential diagnostic and therapeutic targets in CRC.

MOLECULAR CANCER (2021)

Add to Collection

Article Oncology

Circular RNA hsa_circ_0072309 inhibits the proliferation, invasion and migration of gastric cancer cells via inhibition of PI3K/AKT signaling by activating PPARγ/PTEN signaling

Xingpo Guo et al.

Summary: hsa_circ_0072309 inhibits proliferation, invasion, and migration of gastric cancer cells via activation of the PPAR gamma/PTEN pathway and inhibition of the PI3K/AKT signaling pathway. Targeting hsa_circ_0072309 may be an innovative therapeutic strategy for the treatment of GC.

MOLECULAR MEDICINE REPORTS (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Baicalein Represses Cervical Cancer Cell Growth, Cell Cycle Progression and Promotes Apoptosis via Blocking AKT/mTOR Pathway by the Regulation of circHIAT1/miR-19a-3p Axis

Jiaojiao Hu et al.

Summary: This study demonstrated that baicalein inhibits cervical cancer cell growth and promotes apoptosis by regulating circHIAT1 and miR-19a-3p, leading to the inhibition of the AKT/mTOR pathway and ultimately suppressing the progression of cervical cancer.

ONCOTARGETS AND THERAPY (2021)

Add to Collection

Article Cell Biology

CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129

Zhanqin Zhang et al.

Summary: This study revealed that circRAB11FIP1 is upregulated in epithelial ovarian cancer and can mediate autophagy by sponging miR-129 to regulate ATG7 and ATG14. CircRAB11FIP1 may serve as a candidate biomarker for diagnosis and treatment of EOC.

CELL DEATH & DISEASE (2021)

Add to Collection

Article Oncology

Bladder cancer risk stratification using a urinary mRNA biomarker panel - A path towards cystoscopy triaging

Eugene Shkolyar et al.

Summary: The study aimed to develop a urinary mRNA biomarker panel for risk stratification in patients undergoing bladder cancer screening and surveillance. Results showed that the expression of ROBOT, CRH, and IGF2 correlated with increased-risk disease, with a sensitivity of 92.5% and specificity of 73.5%. The overall calculated standardized net benefit of the model was 0.81.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2021)

Add to Collection

Article Oncology

Multiple Omics Integration Reveals Key Circular RNAs in Hepatocellular Carcinoma

Zi-Li Huang et al.

Summary: This study identified and quantified circRNAs in HCC tissues using RNA-seq data, and found several circRNAs closely associated with HCC progression. The integrative analysis of circRNAs greatly improved our understanding of the underlying mechanisms in HCC.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Profiling of circular RNAs and circTPCN/miR-634/mTOR regulatory pathway in cervical cancer

Du Tian-zhao et al.

Summary: This study identified a large number of differentially expressed circular RNAs in cervical cancer samples, with circTPCN and circFAM185A significantly upregulated and potentially serving as biomarkers. Knockdown of circTPCN inhibited proliferation, migration, and invasion, while promoting apoptosis in cervical cancer cells. The study suggests that circTPCN could be a potential therapeutic target in cervical cancer through its regulatory pathway involving miR-634 and mTOR.

GENOMICS (2021)

Add to Collection

Review Medical Laboratory Technology

Translation role of circRNAs in cancers

Yaqin Lu et al.

Summary: Circular RNAs (circRNAs) are a unique class of RNA molecules that play significant roles in translation. Through molecular validation and experiments with green fluorescent protein (GFP), the translation potential of circRNAs has been confirmed. Proteins/peptides encoded by verified circRNAs have been shown to play important roles in human cancers.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

Add to Collection

Article Oncology

FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma

Taoyue Yang et al.

Summary: The study found that circRHOBTB3 is highly expressed in PDAC, promoting autophagy and proliferation of PDAC cells through regulation of the miR-600/NACC1/Akt/mTOR axis. Clinically, the expression levels of circRHOBTB3, miR-600, and NACC1 are correlated with the prognosis of PDAC patients.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Add to Collection

Article Neurosciences

Knockdown circular RNA circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a

Changyun Cao et al.

Summary: The study revealed that overexpression of circGFRA1 in glioma specimens could be inhibited to suppress cell proliferation and migration, increasing cell apoptosis. Acting as a microRNA sponge for miR-99a, circGFRA1 was found to regulate glioma cell behavior. Knockdown of circGFRA1 upregulated miR-99a, leading to reduced expression levels of p/t-AKT, p/t-FOXO1, and p/t-mTOR.

NEUROREPORT (2021)

Add to Collection

Article Gastroenterology & Hepatology

CircRNA_0084927 promotes colorectal cancer progression by regulating miRNA-20b-3p/glutathione S-transferase mu 5 axis

Feng Liu et al.

Summary: The expression of circ_0084927 is significantly increased in CRC, especially in advanced-stage CRC compared to early-stage CRC. Circ_0084927 potentially regulates CRC cell migration and invasion via the miR-20b-3p/GSTM5/AKT/mTOR pathway.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Add to Collection

Article Cell Biology

High-throughput sequencing identified circular RNA circUBE2K mediating RhoA associated bladder cancer phenotype via regulation of miR-516b-5p/ARHGAP5 axis

Chen Yang et al.

Summary: This study identified circUBE2K as a tumor-promoting circRNA in bladder cancer, which functions as a ceRNA to regulate ARHGAP5 expression via sponging miR-516b-5p.

CELL DEATH & DISEASE (2021)

Add to Collection

Article Cell Biology

CircC16orf62 promotes hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis

Shuai Zhang et al.

Summary: CircC16orf62 acts as an oncogene in HCC progression, promoting cancer development through the miR-138-5p/PTK2/Akt pathway. It functions as a molecular sponge for miR-138-5p and a competitive endogenous RNA for PTK2, activating the AKT/mTOR pathway.

CELL DEATH & DISEASE (2021)

Add to Collection

Review Oncology

Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies

Xueping Tao et al.

Summary: Circular RNAs (circRNAs) are endogenous RNA molecules produced by alternative splicing, which play important roles in the proliferation, differentiation, invasion, and metastasis of cancer cells through various mechanisms. They are expected to provide novel perspectives for the diagnoses and treatments of gastrointestinal malignancies.

CANCER BIOLOGY & MEDICINE (2021)

Add to Collection

Review Oncology

Leukaemia: a model metastatic disease

Andrew E. Whiteley et al.

Summary: Leukaemia cells possess innate migration and invasion abilities, unlike solid tumours which require genetic modifications for effective metastasis. Therefore, although traditionally not considered as metastatic diseases, leukaemias are actually models of highly efficient metastatic spread and are challenging to treat.

NATURE REVIEWS CANCER (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Circular RNA hsa_circ_0000117 accelerates the proliferation and invasion of gastric cancer cells by regulating the microRNA-337-3p/signal transducer and activator of transcription 3 axis

Qin Gao et al.

Summary: The study found that in gastric cancer cells, the expression of hsa_circ_0000117 is increased while miR-337-3p is decreased, along with an increase in STAT3 expression. Decreased hsa_circ_0000117 can inhibit proliferation and invasion of gastric cancer, and hsa_circ_0000117 acts as a sponge for miR-337-3p, working together with the miR-337-3p/STAT3 axis to exhibit oncogene properties.

BIOENGINEERED (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Circular RNA ciRS-7 inhibits autophagy of ESCC cells by functioning as miR-1299 sponge to target EGFR signaling

Lingjiao Meng et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

CircRNA: a rising star in gastric cancer

Rong Li et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Add to Collection

Article Cell Biology

MicroRNA-206 upregulation relieves circTCF25-induced osteosarcoma cell proliferation and migration

Yongkun Wang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas

Jiehua He et al.

MOLECULAR CANCER (2020)

Add to Collection

Review Cell Biology

mTOR at the nexus of nutrition, growth, ageing and disease

Grace Y. Liu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Add to Collection

Article Cell Biology

CircRNA WHSC1 targets the miR-646/NPM1 pathway to promote the development of endometrial cancer

Yao Liu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer

Yao Kong et al.

MOLECULAR CANCER (2020)

Add to Collection

Article Oncology

circRNA MYLK Accelerates Cervical Cancer via Up-Regulation of RHEB and Activation of mTOR Signaling

Rui Chen et al.

CANCER MANAGEMENT AND RESEARCH (2020)

Add to Collection

Article Cell Biology

Circular RNA circMBOAT2 promotes prostate cancer progression via a miR-1271-5p/mTOR axis

Juanyi Shi et al.

AGING-US (2020)

Add to Collection

Article Oncology

Serum-derived three-circRNA signature as a diagnostic biomarker for hepatocellular carcinoma

Xiang-Hong Sun et al.

CANCER CELL INTERNATIONAL (2020)

Add to Collection

Article Oncology

Circular RNA LPAR3 sponges microRNA-198 to facilitate esophageal cancer migration, invasion, and metastasis

Yijun Shi et al.

CANCER SCIENCE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells

Nan Zhang et al.

MOLECULAR CANCER (2020)

Add to Collection

Article Oncology

CircRNA hsa_circ_0002577 accelerates endometrial cancer progression through activating IGF1R/PI3K/Akt pathway

Yu Wang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Add to Collection

Article Biology

CircHIPK3/miR-381-3p axis modulates proliferation, migration, and glycolysis of lung cancer cells by regulating the AKT/mTOR signaling pathway

Feng Gu et al.

OPEN LIFE SCIENCES (2020)

Add to Collection

Article Oncology

CircRNA_0000392 promotes colorectal cancer progression through the miR-193a-5p/PIK3R3/AKT axis

Hanchen Xu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Circular RNA: metabolism, functions and interactions with proteins

Wei-Yi Zhou et al.

MOLECULAR CANCER (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway

Xing Zhang et al.

MOLECULAR CANCER (2019)

Add to Collection

Article Oncology

CircRNA-100338 Is Associated With mTOR Signaling Pathway and Poor Prognosis in Hepatocellular Carcinoma

Xiu-Yan Huang et al.

FRONTIERS IN ONCOLOGY (2019)

Add to Collection

Article Oncology

CircPCMTD1 Acts as the Sponge of miR-224-5p to Promote Glioma Progression

Si-Qi Zheng et al.

FRONTIERS IN ONCOLOGY (2019)

Add to Collection

Article Oncology

FBXW7 circular RNA regulates proliferation, migration and invasion of colorectal carcinoma through NEK2, mTOR, and PTEN signaling pathways in vitro and in vivo

Haoran Lu et al.

BMC CANCER (2019)

Add to Collection

Review Genetics & Heredity

The biogenesis, biology and characterization of circular RNAs

Lasse S. Kristensen et al.

NATURE REVIEWS GENETICS (2019)

Add to Collection

Review Oncology

mTOR: Role in cancer, metastasis and drug resistance

Avaniyapuram Kannan Murugan

SEMINARS IN CANCER BIOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation

Feng Yang et al.

MOLECULAR CANCER (2019)

Add to Collection

Review Oncology

CRISPR-Cas: a tool for cancer research and therapeutics

Hao Yin et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Add to Collection

Article Multidisciplinary Sciences

Circular METRN RNA hsa_circ_0037251 Promotes Glioma Progression by Sponging miR-1229-3p and Regulating mTOR Expression

Qinchen Cao et al.

SCIENTIFIC REPORTS (2019)

Add to Collection

Review Oncology

Recent Progress in Characterizing Long Noncoding RNAs in Cancer Drug Resistance

Wenyuan Zhao et al.

JOURNAL OF CANCER (2019)

Add to Collection

Article Oncology

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

Yibing Yang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Add to Collection

Article Oncology

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

Yibing Yang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Add to Collection

Article Gastroenterology & Hepatology

Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy

Massimiliano di Pietro et al.

GASTROENTEROLOGY (2018)

Add to Collection

Review Medicine, General & Internal

Hepatocellular carcinoma

Alejandro Forner et al.

LANCET (2018)

Add to Collection

Review Oncology

PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux

Jake S. O'Donnell et al.

SEMINARS IN CANCER BIOLOGY (2018)

Add to Collection

Article Oncology

Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis

Jie Li et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Add to Collection

Review Medicine, Research & Experimental

Emerging Roles of Circular RNAs in Osteosarcoma

Chenyu Wang et al.

MEDICAL SCIENCE MONITOR (2018)

Add to Collection

Review Oncology

mTOR signalling and cellular metabolism are mutual determinants in cancer

Dirk Mossmann et al.

NATURE REVIEWS CANCER (2018)

Add to Collection

Review Biochemistry & Molecular Biology

mTORC1 and mTORC2 in cancer and the tumor microenvironment

L. C. Kim et al.

ONCOGENE (2017)

Add to Collection

Review Biochemistry & Molecular Biology

The biology of Hepatocellular carcinoma: implications for genomic and immune therapies

Galina Khemlina et al.

MOLECULAR CANCER (2017)

Add to Collection

Article Oncology

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

Xin Jin et al.

CANCER RESEARCH (2017)

Add to Collection

Article Plant Sciences

A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation

Vanessa M. Conn et al.

NATURE PLANTS (2017)

Add to Collection

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth, Metabolism, and Disease

Robert A. Saxton et al.

CELL (2017)

Add to Collection

Article Gastroenterology & Hepatology

Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers

Yoshinaga Okugawa et al.

GASTROENTEROLOGY (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Exon-intron circular RNAs regulate transcription in the nucleus

Zhaoyong Li et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Add to Collection

Review Cardiac & Cardiovascular Systems

Pulmonary manifestations of renal cell carcinoma

Abhinav Agrawal et al.

RESPIRATORY MEDICINE (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Exon-intron circular RNAs regulate transcription in the nucleus

Zhaoyong Li et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Add to Collection

Article Biochemistry & Molecular Biology

circRNA Biogenesis Competes with Pre-mRNA Splicing

Reut Ashwal-Fluss et al.

MOLECULAR CELL (2014)

Add to Collection

Review Biotechnology & Applied Microbiology

Detecting and characterizing circular RNAs

William R. Jeck et al.

NATURE BIOTECHNOLOGY (2014)

Add to Collection

Review Biotechnology & Applied Microbiology

PI3K and cancer: lessons, challenges and opportunities

David A. Fruman et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Add to Collection

Review Biochemistry & Molecular Biology

Chemical Inhibitors and microRNAs (miRNA) Targeting the Mammalian Target of Rapamycin (mTOR) Pathway: Potential for Novel Anticancer Therapeutics

Naif AlQurashi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Add to Collection

Article Multidisciplinary Sciences

mTOR kinase structure, mechanism and regulation

Haijuan Yang et al.

NATURE (2013)

Add to Collection

Article Multidisciplinary Sciences

Natural RNA circles function as efficient microRNA sponges

Thomas B. Hansen et al.

NATURE (2013)

Add to Collection

Article Multidisciplinary Sciences

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

Issam Ben-Sahra et al.

SCIENCE (2013)

Add to Collection

Review Oncology

mTOR as a therapeutic target in patients with gastric cancer

Salah-Eddin Al-Batran et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

Add to Collection

Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

Add to Collection

Article Biochemistry & Molecular Biology

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Katrin Duevel et al.

MOLECULAR CELL (2010)

Add to Collection

Article Multidisciplinary Sciences

mTOR complex 2 in adipose tissue negatively controls whole-body growth

Nadine Cybulski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Add to Collection

Article Cell Biology

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Thomas Porstmann et al.

CELL METABOLISM (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis

Li Ma et al.

CELL (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis

L Ma et al.

CELL (2005)

Add to Collection

Article Biochemistry & Molecular Biology

TSC2 mediates cellular energy response to control cell growth and survival

K Inoki et al.

CELL (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.